About: Management of Severe Malaria and Severe Dengue in Resource-Limited Settings

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Management of Severe Malaria and Severe Dengue in Resource-Limited Settings
Creator	Wills, Bridget Nguyen, Mai Dondorp, Arjen Schultz, M Schultz, Marcus Hoang, Thi Dondorp, A Dünser, M Dünser, Martin Mer, Mervyn Nakibuuka, Jane Hoang, M Mer, M Mohanty, S Mohanty, Sanjib Thwaites, C Wills, ·
source	PMC
abstract	This chapter summarizes recommendations on important aspects of the management of patients with severe malaria and severe dengue. Severe falciparum malaria requires rapid parasitological diagnosis by microscopy or rapid diagnostic test (RCT) and prompt initiation of parenteral artesunate. Fluid bolus therapy should be avoided in patients without hypotensive shock, and we suggest initial (24 h) crystalloid fluid therapy of 2–4 mL/kg/h, which may subsequently be reduced to 1 mL/kg/h in patients receiving additional fluids, e.g., through enteral tube feeding. In the minority of those patients presenting with hypotensive shock, we suggest fluid bolus therapy (30 mL/kg) with an isotonic crystalloid and early initiation of vasopressor support. Enteral feeding in non-intubated adult patients with cerebral malaria can start after 60 h, to avoid aspiration pneumonia. There are insufficient data to suggest this in pediatric cerebral malaria. The diagnosis of severe dengue is commonly with a combined dengue antigen (NS1) and antibody RDT. No antiviral treatment is currently available. Dengue shock results from capillary leakage, although hemorrhage or depression of myocardial contractility can contribute. The World Health Organization guidelines recommend restoration of the circulation guided by pulse pressure, capillary refill time, hematocrit, and urine output. Large (>15 mL/kg) rapid (<30 min) fluid boluses should be avoided, but prompt fluid administration with crystalloids is essential and should be restricted as soon as the critical phase is over to avoid pulmonary edema. Corticosteroids are not recommended, neither is platelet transfusion for thrombocytopenia in the absence of active bleeding or other risk factors.
has issue date	2019-02-09(xsd:dateTime)
bibo:doi	10.1007/978-3-030-03143-5_9
bibo:pmid	32091688
has license	cc-by
sha1sum (hex)	7358517c091cf2b4d0e035e7d12d4fef2d1deb4b
schema:url	https://doi.org/10.1007/978-3-030-03143-5_9
resource representing a document's title	Management of Severe Malaria and Severe Dengue in Resource-Limited Settings
has PubMed Central identifier	PMC7123178
has PubMed identifier	32091688
schema:publication	Sepsis Management in Resource-limited Settings
resource representing a document's body	covid:7358517c091cf2b4d0e035e7d12d4fef2d1deb4b#body_text
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