About: The Canarypox-virus vaccine vector ALVAC triggers the release of IFN-γ by Natural Killer (NK) cells enhancing Th1 polarization

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About: The Canarypox-virus vaccine vector ALVAC triggers the release of IFN-γ by Natural Killer (NK) cells enhancing Th1 polarization Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Canarypox-virus vaccine vector ALVAC triggers the release of IFN-γ by Natural Killer (NK) cells enhancing Th1 polarization
Creator	Burdin, Nicolas Harenberg, Anke Ryan, Elizabeth
Source	Elsevier; Medline; PMC
abstract	Abstract We investigated the mechanism by which ALVAC activates innate immunity. Combining ALVAC with protein antigens significantly augmented antigen-specific IgG2a responses; this was dependent on the presence of bioactive interferon (IFN)-γ. Immuno-depletion of NK cells prior to ALVAC immunisation abrogated IFN-γ production indicating that they are the main cellular source of early IFN-γ in vivo. Murine bone-marrow derived dendritic cells (BMDCs) cultured in the presence of ALVAC secreted high levels of the chemokines CXCL10 and CCL2 and up-regulated expression of the maturation markers CD40, CD80 and CD86. Therefore, we conclude that ALVAC acts as an adjuvant through a mechanism requiring NK cell derived IFN-γ, DC activation and chemokine secretion.
has issue date	2007-04-30(xsd:dateTime)
bibo:doi	10.1016/j.vaccine.2006.12.048
bibo:pmid	17234309
has license	els-covid
sha1sum (hex)	737b7ac2d2c39661379d73a47bdbf3d4d75eadf8
schema:url	https://doi.org/10.1016/j.vaccine.2006.12.048
resource representing a document's title	The Canarypox-virus vaccine vector ALVAC triggers the release of IFN-γ by Natural Killer (NK) cells enhancing Th1 polarization
has PubMed Central identifier	PMC7115637
has PubMed identifier	17234309
schema:publication	Vaccine
resource representing a document's body	covid:737b7ac2d2c39661379d73a47bdbf3d4d75eadf8#body_text
is schema:about of	named entity 'BONE-MARROW' named entity 'CD86' named entity 'NK CELLS' named entity 'IGG2A' named entity 'SPECIFIC' named entity 'CHEMOKINE SECRETION' named entity 'RESPONSES' named entity 'EARLY' named entity '90%' named entity 'IMMUNISATION' named entity 'DENDRITIC CELLS' named entity 'MARKERS' named entity 'MAIN' named entity 'ACTIVATES' named entity 'CCL2' named entity 'ANTIGEN' named entity 'CD80' named entity 'INTERFERON ' named entity 'ALVAC' named entity 'HIGH' named entity 'DEPLETION' named entity 'PRIOR TO' named entity 'ACTIVATION' named entity 'MECHANISM' named entity 'CONCLUDE' named entity 'IN VIVO' named entity 'SECRETED' named entity 'CXCL10' named entity 'VECTOR' named entity 'PROTEIN ' named entity 'MURINE' named entity 'CELLS' named entity 'ENHANCING' named entity 'NATURAL KILLER' named entity 'IFN' named entity 'CANARYPOX' named entity '90%' named entity 'TRIGGERS' named entity 'POLARIZATION' named entity 'VIRUS VACCINE' named entity 'ANTIGENS' named entity 'PRESENCE OF' named entity 'NK CELL' named entity 'PRODUCTION' named entity 'SOURCE' named entity 'LEVELS' named entity 'ADJUVANT' named entity 'INDICATING' named entity 'DEPENDENT' named entity 'CELLULAR' named entity 'CHEMOKINES' named entity 'IFN' named entity 'UP-REGULATED EXPRESSION' named entity 'COMBINING' named entity 'ACTS' named entity 'INNATE IMMUNITY' named entity 'MATURATION' named entity 'CD40' named entity 'CULTURED' named entity 'DERIVED' named entity 'ALVAC' named entity 'RELEASE' named entity 'TH1' named entity 'INVESTIGATED' named entity 'AUGMENTED' covid:arg/737b7ac2d2c39661379d73a47bdbf3d4d75eadf8 named entity 'antigen' named entity 'IFN' named entity 'CD40' named entity 'CXCL10' named entity 'bioactive' named entity 'IgG2a' named entity 'vaccine' named entity 'Natural Killer' named entity 'virus' named entity 'Evry' named entity 'signalling pathways' named entity 'mice' named entity 'immunisation'

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