About: ADAM17-dependent signaling is required for oncogenic human papillomavirus entry platform assembly

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About: ADAM17-dependent signaling is required for oncogenic human papillomavirus entry platform assembly Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	ADAM17-dependent signaling is required for oncogenic human papillomavirus entry platform assembly
Creator	Boukhallouk, Fatima Florin, Luise Lang, Thorsten Ana Mikulič Ić, Snjež Homsi, Yahya Reiss, Karina Rô Me Finke, Jé Sons, Dominik Wü Stenhagen, Elena
Source	PMC
abstract	Oncogenic human papillomaviruses (HPV) are small DNA viruses that infect keratinocytes. After HPV binding to cell surface receptors, a cascade of molecular interactions mediates the infectious cellular internalization of virus particles. Aside from the virus itself, important molecular players involved in virus entry include the tetraspanin CD151 and the epidermal growth factor receptor (EGFR). To date, it is unknown how these components are coordinated in space and time. Here, we studied plasma membrane dynamics of CD151 and EGFR and the HPV16 capsid during the early phase of infection. We find that the proteinase ADAM17 activates the extracellular signal-regulated kinases (ERK1/2) pathway by the shedding of growth factors which triggers the formation of an endocytic entry platform. Infectious endocytic entry platforms carrying virus particles consist of two-fold larger CD151 domains containing the EGFR. Our finding clearly dissects initial virus binding from ADAM17-dependent assembly of a HPV/CD151/EGFR entry platform.
has issue date	2019-05-20(xsd:dateTime)
bibo:doi	10.7554/elife.44345
bibo:pmid	31107240
has license	cc-by
sha1sum (hex)	73a2171fc7716dd485b9c3348902a7672213fc0a
schema:url	https://doi.org/10.7554/elife.44345
resource representing a document's title	ADAM17-dependent signaling is required for oncogenic human papillomavirus entry platform assembly
has PubMed Central identifier	PMC6557631
has PubMed identifier	31107240
resource representing a document's body	covid:73a2171fc7716dd485b9c3348902a7672213fc0a#body_text
is schema:about of	named entity 'HPV16' named entity 'internalization' named entity 'PATHWAY' named entity 'VIRUS PARTICLES' named entity 'SMALL' named entity 'INTERNALIZATION' named entity 'FOLD' named entity 'COMPONENTS' named entity 'PLASMA MEMBRANE' covid:arg/73a2171fc7716dd485b9c3348902a7672213fc0a named entity 'EGFR' named entity 'INVOLVED' named entity 'CELLULAR' named entity 'ENTRY' named entity 'HPV' named entity 'ADAM17' named entity 'PROTEINASE' named entity 'CONSIST' named entity 'EXTRACELLULAR SIGNAL-REGULATED KINASES' named entity 'HUMAN PAPILLOMAVIRUS ' named entity 'DEPENDENT' named entity 'COORDINATED' named entity 'CASCADE' named entity 'SIGNALING' named entity 'ASSEMBLY' named entity 'PLATFORM' named entity 'ADAM17' named entity 'ENTRY' named entity 'HPV16' named entity 'EPIDERMAL GROWTH FACTOR RECEPTOR' named entity 'SPACE AND TIME' named entity 'PLAYERS' named entity 'CELL SURFACE' named entity 'CONTAINING' named entity 'VIRUS BINDING' named entity 'ACTIVATES' named entity 'UNKNOWN' named entity 'LARGER' named entity 'EARLY' named entity 'VIRUS' named entity 'MOLECULAR' named entity 'DATE' named entity 'TRIGGERS' named entity 'HERE' named entity 'IMPORTANT' named entity 'INFECTIOUS' named entity 'DYNAMICS' named entity 'DEPENDENT' named entity 'INFECTION' named entity 'VIRUS ENTRY' named entity 'CAPSID' named entity 'BINDING' named entity 'ASSEMBLY' named entity 'TETRASPANIN' named entity 'FINDING' named entity 'INITIAL' named entity 'HUMAN PAPILLOMAVIRUSES' named entity 'KERATINOCYTES' named entity 'OUR' named entity 'RECEPTORS' named entity 'SHEDDING' named entity 'FORMATION' named entity 'MEDIATES' named entity 'CD151' named entity 'INCLUDE' named entity 'CARRYING' named entity 'THESE' named entity 'DNA VIRUSES' named entity 'PHASE' named entity 'REQUIRED' named entity 'HOW' named entity 'INFECT' named entity 'GROWTH FACTORS' named entity 'MOLECULAR INTERACTIONS'

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