About: Immune predictors of oral poliovirus vaccine immunogenicity among infants in South India

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Immune predictors of oral poliovirus vaccine immunogenicity among infants in South India
Creator	Kang, Gagandeep Praharaj, Ira Iturriza-Gómara, Miren Kampmann, Beate Grassly, Nicholas John, Jacob Babji, Sudhir Chen, Yin-Huai Giri, Sidhartha Jeyavelu, Nithya Kaliappan, Saravanakumar Manickavasagam, Punithavathy Parker, Edward Syed, Chanduni Uhlig, Holm Venugopal, Srinivasan Vincy, Nisha
Source	PMC
abstract	Identification of the causes of poor oral vaccine immunogenicity in low-income countries might lead to more effective vaccines. We measured mucosal and systemic immune parameters at the time of vaccination with oral poliovirus vaccine (OPV) in 292 Indian infants aged 6–11 months, including plasma cytokines, leukocyte counts, fecal biomarkers of environmental enteropathy and peripheral blood T-cell phenotype, focused on gut-homing regulatory CD4+ populations. We did not find a distinct immune phenotype associated with OPV immunogenicity, although viral pathogens were more prevalent in stool at the time of immunization among infants who failed to seroconvert (63.9% vs. 45.6%, p = 0.002). Using a machine-learning approach, we could predict seroconversion a priori using immune parameters and infection status with a median 58% accuracy (cross-validation IQR: 50–69%) compared with 50% expected by chance. Better identification of immune predictors of OPV immunogenicity is likely to require sampling of mucosal tissue and improved oral poliovirus infection models.
has issue date	2020-03-23(xsd:dateTime)
bibo:doi	10.1038/s41541-020-0178-5
bibo:pmid	32218999
has license	cc-by
sha1sum (hex)	73c8ca3e77bb63ef59e98f5eccae841fd802aee4
schema:url	https://doi.org/10.1038/s41541-020-0178-5
resource representing a document's title	Immune predictors of oral poliovirus vaccine immunogenicity among infants in South India
has PubMed Central identifier	PMC7089977
has PubMed identifier	32218999
schema:publication	NPJ Vaccines
resource representing a document's body	covid:73c8ca3e77bb63ef59e98f5eccae841fd802aee4#body_text
is schema:about of	named entity 'STOOL' named entity 'VIRAL PATHOGENS' named entity 'USING' named entity 'HOMING' named entity 'INCLUDING' named entity 'poliovirus vaccine' named entity 'sampling' named entity 'biomarkers' named entity 'mucosal tissue' named entity 'OPV' named entity 'T-cell' named entity 'seroconvert' named entity 'phenotype' named entity 'OPV' named entity 'machine-learning approach' named entity 'immunization' named entity 'OPV' named entity 'calprotectin' named entity 'seroconversion' named entity 'oral vaccine' named entity 'inflammation' named entity 'Eotaxin' named entity 'regulatory T cells' named entity 'plasma' named entity 'cytokines' named entity 'immunogenicity' named entity 'TNF-α' named entity 'inflammation' named entity 'oral vaccine' named entity 'enterovirus infection' named entity 'intestinal biopsies' named entity 'immunogenicity' named entity 'out-of-sample' named entity 'heatmap' named entity 'random sample' named entity 'commensals' named entity 'vaccination' named entity 'OPV' named entity 'OPV' named entity 'PBMCs' named entity 'plasma' named entity 'Sapovirus' named entity 'IFN-γ' named entity 'antibody' named entity 'bacterial pathogens' named entity 'clinical trial' named entity 'lymphocyte subsets' named entity 'vaccination' named entity 'transplacental' named entity 'sub-Saharan' named entity 'vaccination' named entity 'vaccine' named entity 'cytokines' named entity 'OPV' named entity 'seasonal component' named entity 'algorithm' named entity 'microbial' named entity 'vaccination' named entity 'Rotavirus' named entity 'poliovirus' named entity 'pediatric' named entity 'placebo' named entity 'immune response' named entity 'immunization' named entity 'biomarkers'

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