About: Spatial pattern of genetic diversity and selection in the MHC class II DRB of three Neotropical bat species

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About: Spatial pattern of genetic diversity and selection in the MHC class II DRB of three Neotropical bat species Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Spatial pattern of genetic diversity and selection in the MHC class II DRB of three Neotropical bat species
Creator	Crouau-Roy, Brigitte Lacoste, Vincent Lavergne, Anne Salmier, Arielle Benoit De Thoisy,
Source	Medline; PMC
abstract	BACKGROUND: Although bats are natural reservoirs of many pathogens, few studies have been conducted on the genetic variation and detection of selection in major histocompatibility complex (MHC) genes. These genes are critical for resistance and susceptibility to diseases, and host–pathogen interactions are major determinants of their extensive polymorphism. Here we examined spatial patterns of diversity of the expressed MHC class II DRB gene of three sympatric Neotropical bats, Carollia perspicillata and Desmodus rotundus (Phyllostomidae), and Molossus molossus (Molossidae), all of which use the same environments (e.g., forests, edge habitats, urban areas). Comparison with neutral marker (mtDNA D-loop) diversity was performed at the same time. RESULTS: Twenty-three DRB alleles were identified in 19 C. perspicillata, 30 alleles in 35 D. rotundus and 20 alleles in 28 M. molossus. The occurrence of multiple DRB loci was found for the two Phyllostomidae species. The DRB polymorphism was high in all sampling sites and different signatures of positive selection were detected depending on the environment. The patterns of DRB diversity were similar to those of neutral markers for C. perspicillata and M. molossus. In contrast, these patterns were different for D. rotundus for which a geographical structure was highlighted. A heterozygote advantage was also identified for this species. No recombination or gene conversion event was found and phylogenetic relationships showed a trans-species mode of evolution in the Phyllostomids. CONCLUSIONS: This study of MHC diversity demonstrated the strength of the environment and contrasting pathogen pressures in shaping DRB diversity. Differences between positively selected sites identified in bat species highlighted the potential role of gut microbiota in shaping immune responses. Furthermore, multiple geographic origins and/or population admixtures observed in C. perspicillata and M. molossus populations acted as an additional force in shaping DRB diversity. In contrast, DRB diversity of D. rotundus was shaped by environment rather than demographic history. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12862-016-0802-1) contains supplementary material, which is available to authorized users.
has issue date	2016-10-26(xsd:dateTime)
bibo:doi	10.1186/s12862-016-0802-1
bibo:pmid	27782798
has license	cc-by
sha1sum (hex)	73d9db430955cb7c45280e5e29981795c674848f
schema:url	https://doi.org/10.1186/s12862-016-0802-1
resource representing a document's title	Spatial pattern of genetic diversity and selection in the MHC class II DRB of three Neotropical bat species
has PubMed Central identifier	PMC5080761
has PubMed identifier	27782798
schema:publication	BMC Evol Biol
resource representing a document's body	covid:73d9db430955cb7c45280e5e29981795c674848f#body_text
is schema:about of	named entity 'determinants' named entity 'extensive' named entity 'host-pathogen interactions' named entity 'MHC CLASS II' named entity 'SPATIAL' named entity 'BATS' named entity 'EDGE' named entity 'DETECTION' named entity 'SUSCEPTIBILITY' named entity 'time' named entity 'selection' named entity 'Carollia' named entity 'polymorphism' named entity 'bats' named entity 'genes' named entity 'neutral' named entity 'susceptibility' named entity 'Spatial' named entity 'mtDNA' named entity 'Desmodus rotundus' named entity 'major histocompatibility complex' named entity 'MHC class II' named entity 'Phyllostomidae' named entity 'polymorphism' named entity 'genetic diversity' named entity 'bat species' named entity 'MHC class II' named entity 'D-loop' named entity 'coevolution' named entity 'PBR' named entity 'Invitrogen' named entity 'positive selection' named entity 'HyPhy' named entity 'MHC class II' named entity 'Noctilio' named entity 'reading frame' named entity 'gene' named entity 'rarefaction' named entity 'gene conversion' named entity 'nucleotide' named entity 'algorithm' named entity 'homology' named entity 'Z-test' named entity 'D. rotundus' named entity 'primers' named entity 'trans' named entity 'exon' named entity 'C. perspicillata' named entity 'genetic variability' named entity 'Markov Chain Monte Carlo' named entity 'antigen-binding' named entity 'gene' named entity 'C. perspicillata' named entity 'C. perspicillata' named entity 'alleles' named entity 'mtDNA' named entity 'statistical significance' named entity 'HLA-DRB1' named entity 'human species' named entity 'trans' named entity 'GenBank' named entity 'pathogen' named entity 'monophyletic origin' named entity 'haplotypes' named entity 'species richness' named entity 'positively selected' named entity 'recombinant' named entity 'exon' named entity 'bat species' named entity 'positively selected' named entity 'posterior probability' named entity 'Beckman Coulter' named entity 'C. perspicillata' named entity 'Mantel test' named entity 'AICc' named entity 'gene' named entity 'foraging'

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