About: Hepatitis E Virus Drug Development

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Hepatitis E Virus Drug Development
Creator	Kinast, Volker Steinmann, Eike Todt, Daniel Burkard, Thomas
Source	Medline; PMC
abstract	Hepatitis E virus (HEV) is an underestimated disease, leading to estimated 20 million infections and up to 70,000 deaths annually. Infections are mostly asymptomatic but can reach mortality rates up to 25% in pregnant women or become chronic in immunocompromised patients. The current therapy options are limited to the unspecific antivirals Ribavirin (RBV) and pegylated Interferon-α (pegIFN-α). RBV leads to viral clearance in only 80% of patients treated, and is, similar to pegIFN-α, contraindicated in the major risk group of pregnant women, emphasizing the importance of new therapy options. In this review, we focus on the urgent need and current efforts in HEV drug development. We provide an overview of the current status of HEV antiviral research. Furthermore, we discuss strategies for drug development and the limitations of the approaches with respect to HEV.
has issue date	2019-05-28(xsd:dateTime)
bibo:doi	10.3390/v11060485
bibo:pmid	31141919
has license	cc-by
sha1sum (hex)	73de62f8272982125df5a376a10f99267968c6e4
schema:url	https://doi.org/10.3390/v11060485
resource representing a document's title	Hepatitis E Virus Drug Development
has PubMed Central identifier	PMC6631701
has PubMed identifier	31141919
schema:publication	Viruses
resource representing a document's body	covid:73de62f8272982125df5a376a10f99267968c6e4#body_text
is schema:about of	named entity 'DRUG DEVELOPMENT' named entity 'antiviral' named entity 'Hepatitis E' named entity 'LEADING' covid:arg/73de62f8272982125df5a376a10f99267968c6e4 named entity 'STATUS' named entity '70%' named entity 'URGENT' named entity 'APPROACHES' named entity 'TREATED' named entity 'DEATHS' named entity 'HEV' named entity 'ANTIVIRAL' named entity 'RIBAVIRIN' named entity 'CHRONIC' named entity 'VIRAL CLEARANCE' named entity 'PREGNANT WOMEN' named entity 'NEW THERAPY' named entity 'OPTIONS' named entity 'ESTIMATED' named entity 'LIMITED' named entity 'CURRENT' named entity 'PATIENTS' named entity 'VIRUSES HEPATITIS' named entity 'STRATEGIES' named entity 'LEADS' named entity 'CONTRAINDICATED' named entity 'CURRENT THERAPY' named entity 'MILLION' named entity 'HEPATITIS E VIRUS' named entity 'ASYMPTOMATIC' named entity 'PEGYLATED' named entity 'DISEASE' named entity 'NEED' named entity 'PROVIDE' named entity 'OVERVIEW' named entity 'RESPECT' named entity 'INTERFERON' named entity 'REACH' named entity 'LIMITATIONS' named entity 'RISK GROUP' named entity 'DRUG DEVELOPMENT' named entity 'FOCUS' named entity 'IMMUNOCOMPROMISED PATIENTS' named entity 'REVIEW' named entity 'DISCUSS' named entity 'RESEARCH' named entity 'MORTALITY RATES' named entity 'UP TO' named entity 'ANTIVIRALS' named entity 'ANNUALLY' named entity '80%' named entity 'MAJOR' named entity 'INFECTIONS' named entity 'HEPATITIS E VIRUS' named entity 'SIMILAR' named entity 'BUT' named entity 'leads' named entity 'immunocompromised' named entity 'HEV' named entity 'pegylated' named entity 'risk' named entity 'HEV' named entity 'asymptomatic' named entity 'pregnant women' named entity 'antivirals' named entity 'antiviral' named entity 'RdRP' named entity 'ORF1' named entity 'viroporin' named entity 'protease' named entity 'Huh7' named entity 'luciferase' named entity 'morpholine' named entity 'DNA polymerase' named entity 'HEV' named entity 'HEV' named entity 'polyadenylated'

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