About: Full genome analysis of Australian infectious bronchitis viruses suggests frequent recombination events between vaccine strains and multiple phylogenetically distant avian coronaviruses of unknown origin

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Full genome analysis of Australian infectious bronchitis viruses suggests frequent recombination events between vaccine strains and multiple phylogenetically distant avian coronaviruses of unknown origin Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Full genome analysis of Australian infectious bronchitis viruses suggests frequent recombination events between vaccine strains and multiple phylogenetically distant avian coronaviruses of unknown origin
Creator	Vaz, Paola Lee, Sang-Won Browning, Glenn Hartley, Carol Legione, Alistair Noormohammadi, Amir Coppo, Mauricio Markham, Philip Quinteros, José
Source	Elsevier; Medline; PMC
abstract	Australian strains of infectious bronchitis virus (IBV) have been evolving independently for many years, with control achieved by vaccination with local attenuated strains. Previous studies have documented the emergence of recombinants over the last 20 years, with the most recent one, Ck/Aus/N1/08, detected in 2008. These recombinants did not appear to be controlled by the vaccines currently in use. In this study we sequenced the complete genomes of three emergent Australian strains of IBV (IBV/Ck/Aus/N1/88, IBV/Ck/Aus/N1/03 and IBV/Ck/Aus/N1/08) and a previously incompletely characterised vaccine strain, IBV/Ck/Aus/Armidale, and compared them to the genome of the vaccine strain VicS. We detected multiple recombination events throughout the genome between wild type viruses and the vaccine strains in all three emergent isolates. Moreover, we found that strain N1/88 was not entirely exogenous, as was previously hypothesised. Rather, it originated from a recombination event involving the VicS vaccine strain. The S glycoprotein genes of N1/88 and N1/03 were known to be genetically distinct from previously characterised circulating strains and from each other, and the original donors of these genes remains unknown. The S1 glycoprotein gene of N1/88, a subgroup 2 strain, shares a high nucleotide identity with the sequence of the S1 gene of the recent isolate N1/08. As the subgroup 2 strains have not been isolated for at least 20 years, it appears likely that an unknown avian coronavirus that was the donor of the S1 glycoprotein sequence of N1/88 in the 1980s is still recombining with IBV strains in the field.
has issue date	2016-12-25(xsd:dateTime)
bibo:doi	10.1016/j.vetmic.2016.11.003
bibo:pmid	27938680
has license	no-cc
sha1sum (hex)	73f243f45015fbf2c5cf2d386d58dab89f6163b7
schema:url	https://doi.org/10.1016/j.vetmic.2016.11.003
resource representing a document's title	Full genome analysis of Australian infectious bronchitis viruses suggests frequent recombination events between vaccine strains and multiple phylogenetically distant avian coronaviruses of unknown origin
has PubMed Central identifier	PMC7117259
has PubMed identifier	27938680
schema:publication	Vet Microbiol
resource representing a document's body	covid:73f243f45015fbf2c5cf2d386d58dab89f6163b7#body_text
is schema:about of	named entity 'vaccines' named entity 'avian' named entity 'AUSTRALIAN' named entity 'AVIAN CORONAVIRUSES' named entity 'CURRENTLY' named entity 'DOCUMENTED' named entity 'RECOMBINATION' named entity 'ATTENUATED' named entity 'EVOLVING' named entity 'RECOMBINANTS' named entity 'USE' named entity 'HAVE' named entity 'DETECTED' named entity 'GENOME ANALYSIS' named entity 'VIRUSES' named entity 'THESE' named entity 'MOST RECENT' named entity 'UNKNOWN ORIGIN' named entity 'EVENTS' named entity 'FREQUENT' named entity 'DISTANT' named entity 'YEARS' named entity 'EMERGENCE' named entity 'CONTROL' named entity 'APPEAR' named entity 'CONTROLLED BY' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'AUSTRALIAN' named entity 'VACCINATION' named entity 'VACCINES' named entity 'LOCAL' named entity 'DID' named entity 'PREVIOUS' named entity 'VACCINE' named entity 'STRAINS' named entity 'STUDIES' named entity 'INFECTIOUS BRONCHITIS' named entity 'MULTIPLE' named entity 'STRAINS' covid:arg/73f243f45015fbf2c5cf2d386d58dab89f6163b7 named entity '2008' named entity 'origin' named entity 'vaccines' named entity 'recombinants' named entity 'recombinants' named entity 'infectious bronchitis virus' named entity 'genome analysis' named entity 'phylogenetic tree' named entity 'to-5' named entity 'aetiological' named entity 'black lines' named entity 'genome' named entity 'exoribonuclease' named entity 'recombination' named entity 'IBV' named entity 'SimPlot' named entity '1,000,000' named entity 'virus' named entity 'VicS' named entity 'Armidale' named entity 'genomics' named entity 'peplomer' named entity 'polymerase' named entity 'sliding window' named entity 'nucleotides' named entity 'sequence identities' named entity 'Coronaviridae' named entity 'tracheal' named entity 'virus' named entity 'IBV' named entity 'conserved residues' named entity 'probability' named entity 'glycoprotein'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software