About: Porcine circovirus type 2 replication is impaired by inhibition of the extracellular signal-regulated kinase (ERK) signaling pathway

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About: Porcine circovirus type 2 replication is impaired by inhibition of the extracellular signal-regulated kinase (ERK) signaling pathway Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Porcine circovirus type 2 replication is impaired by inhibition of the extracellular signal-regulated kinase (ERK) signaling pathway
Creator	Wei, Li Liu, Jue
Source	Elsevier; Medline; PMC
abstract	Abstract Postweaning multisystemic wasting syndrome, which is primarily caused by porcine circovirus type 2 (PCV2), is an emerging and important swine disease. We have recently shown that PCV2 induces nuclear factor kappa B activation and its activation is required for active replication, but the other cellular factors involved in PCV2 replication are not well defined. The extracellular signal-regulated kinase (ERK) which served as an important component of cellular signal transduction pathways has been shown to regulate many viral infections. In this report, we show that PCV2 activates ERK1/2 in PCV2-infected PK15 cells dependent on viral replication. The PCV2-induced ERK1/2 leads to phosphorylation of the ternary complex factor Elk-1, which kinetically paralleled ERK1/2 activation. Inhibition of ERK activation with U0126, a specific MEK1/2 inhibitor, significantly reduced viral progeny release. Investigations into the mechanism of ERK1/2 regulation revealed that inhibition of ERK activation leads to decreased viral transcription and lower virus protein expression. These data indicate that the ERK signaling pathway is involved in PCV2 infection and beneficial to PCV2 replication in the cultured cells.
has issue date	2009-03-30(xsd:dateTime)
bibo:doi	10.1016/j.virol.2009.01.010
bibo:pmid	19215954
has license	els-covid
sha1sum (hex)	73fd3edae7eff2a590a42dd7e744698881448511
schema:url	https://doi.org/10.1016/j.virol.2009.01.010
resource representing a document's title	Porcine circovirus type 2 replication is impaired by inhibition of the extracellular signal-regulated kinase (ERK) signaling pathway
has PubMed Central identifier	PMC7103411
has PubMed identifier	19215954
schema:publication	Virology
resource representing a document's body	covid:73fd3edae7eff2a590a42dd7e744698881448511#body_text
is schema:about of	named entity 'Inhibition' named entity 'activation' named entity 'kinetically' named entity 'mechanism' named entity 'swine' named entity 'EXTRACELLULAR SIGNAL-REGULATED KINASE' named entity 'TERNARY COMPLEX' named entity 'ACTIVE' named entity 'INDUCED' named entity 'INHIBITOR' named entity 'NOT WELL' named entity 'ERK1' named entity 'ERK' named entity 'CELLS' named entity 'DEPENDENT' named entity 'PROTEIN EXPRESSION' named entity 'U0126' named entity 'MEK1' named entity 'REDUCED' named entity 'BUT' named entity 'VIRUS PROTEIN' named entity 'PK15' named entity 'CELLULAR' named entity 'ERK ACTIVATION' named entity 'VIRAL REPLICATION' named entity 'REPLICATION' named entity 'IMPAIRED' named entity 'SIGNALING PATHWAY' named entity 'THESE' named entity 'SIGNALING PATHWAY' named entity 'PROGENY' named entity 'CAUSED BY' named entity 'VIRAL TRANSCRIPTION' named entity 'WELL DEFINED' named entity 'CULTURED CELLS' named entity 'INHIBITION' named entity 'CELLULAR SIGNAL TRANSDUCTION' named entity 'LOWER' named entity 'PORCINE CIRCOVIRUS TYPE 2' named entity 'NUCLEAR FACTOR KAPPA B' named entity 'COMPLEX FACTOR' named entity 'RELEASE' named entity 'INVOLVED' named entity 'INVESTIGATIONS' named entity 'TO REGULATE' named entity 'HAVE' named entity 'ITS' named entity 'REGULATION' named entity 'REQUIRED' named entity 'LEADS' named entity 'INHIBITION' named entity 'POSTWEANING MULTISYSTEMIC WASTING SYNDROME' named entity 'REVEALED' named entity 'REPORT' named entity 'INFECTED' named entity 'ELK-1' named entity 'MECHANISM' named entity 'INFECTION' named entity 'DECREASED' named entity 'SIGNAL TRANSDUCTION PATHWAYS' named entity 'REPLICATION' named entity 'ACTIVATES' named entity 'RECENTLY' named entity 'PHOSPHORYLATION' named entity 'EXTRACELLULAR SIGNAL-REGULATED KINASE' named entity 'ACTIVATION' named entity 'SPECIFIC' named entity 'VIRAL INFECTIONS' named entity 'DATA' named entity 'BENEFICIAL' named entity 'PORCINE CIRCOVIRUS TYPE 2' named entity 'IMPORTANT' named entity 'SWINE DISEASE' named entity 'VIRAL' named entity 'COMPONENT' covid:arg/73fd3edae7eff2a590a42dd7e744698881448511 named entity 'ternary complex' named entity 'defined' named entity 'Investigations' named entity 'involved'

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