About: Perspectives on the epizootiology of feline enteric coronavirus and the pathogenesis of feline infectious peritonitis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Perspectives on the epizootiology of feline enteric coronavirus and the pathogenesis of feline infectious peritonitis
Creator	Evermann A'b, James Mckeirnan, Alison Ott, Richard
source	Elsevier; Medline; PMC
abstract	Abstract This review presents some current thoughts regarding teh epizootiology of the feline coronaviruses; feline infectious peritonisis virus (FIPV) and feline coronavirus (FEVC), with primary emphasis on the pathogenesis of these viruses in nature. Although the mechanism(s) whereby FIPV causes disease are still incompletely understood, there have been significant contributions to the literature over the past decade which provide a framework upon which plausible explanations can be postulated. Two concepts are presented which attempt to clarify the pathogenesis of FIPV and at the same time may serve as an impetus for further research. The first involves the hypothesis, originally promulgated by Pedersen in 19891, that FIPV is derived from FECV during virus replication in the gastrointestinal tract. The second involves a unique mechanism of the mucosal immune system referred to as oral tolerance, which under normal conditions promotes the production of secretory immunity and suppresses the production of systematic immunity. In the case of FIPV infection, we propose that oral tolerance is important in the control of the virus at the gastrointestinal tract level. Once oral tolerance is disrupted, FIPV is capable of systemic spread resulting in immune-mediated vasculitis and death. Thus, it may be that clinical forms of FIP are due to a combination of two events, the first being the generation of FIPV from FECV, and the second being the capacity of FIPV to circumvent oral tolerance.
has issue date	1991-08-31(xsd:dateTime)
bibo:doi	10.1016/0378-1135(91)90079-u
bibo:pmid	1654668
has license	els-covid
sha1sum (hex)	741d7ee5f41c2dc5f55bd3f3ed51619a67e3b674
schema:url	https://doi.org/10.1016/0378-1135%2891%2990079-u
resource representing a document's title	Perspectives on the epizootiology of feline enteric coronavirus and the pathogenesis of feline infectious peritonitis
has PubMed Central identifier	PMC7117328
has PubMed identifier	1654668
schema:publication	Veterinary Microbiology
resource representing a document's body	covid:741d7ee5f41c2dc5f55bd3f3ed51619a67e3b674#body_text
is schema:about of	named entity 'feline' named entity 'peritonitis' named entity 'PATHOGENESIS' named entity 'EPIZOOTIOLOGY' named entity 'FELINE ENTERIC CORONAVIRUS' named entity 'PATHOGENESIS' named entity 'FELINE INFECTIOUS PERITONITIS' named entity 'EPIZOOTIOLOGY' named entity 'FELINE ENTERIC CORONAVIRUS' named entity 'OTT' named entity 'FELINE INFECTIOUS PERITONITIS' named entity 'VET' named entity 'Perspectives' named entity 'epizootiology' named entity 'pathogenesis' named entity 'epizootiology' named entity 'feline infectious peritonitis' named entity 'FIP' named entity 'Serology' named entity 'pathogenicity' named entity 'asymptomatic' named entity 'FIPV' named entity 'antibodies' named entity 'infection' named entity 'serologic testing' named entity 'Evermann' named entity 'single stranded RNA' named entity 'porcine' named entity 'serology' named entity 'Infection' named entity 'FIP' named entity 'felid' named entity 'genomically' named entity 'systemic circulation' named entity 'oral tolerance' named entity 'Electron microscopy' named entity 'presentation of antigens' named entity 'viral RNA' named entity 'feline panleukopenia' named entity 'immune response' named entity 'feline coronavirus' named entity 'coronaviruses' named entity 'coronavirus' named entity 'seropositive' named entity 'coronaviruses' named entity 'FIPV' named entity 'Barlough' named entity 'FIPV' named entity 'oral tolerance' named entity 'catteries' named entity 'Oral tolerance' named entity 'cat bite' named entity 'etiology' named entity 'cell-mediated' named entity 'FIPV' named entity 'cell culture' named entity 'coronaviruses' named entity 'FIPV' named entity 'IBV' named entity 'hyperplasia' named entity 'phlebitis' named entity 'Evermann' named entity 'FIPV' named entity 'coronavirus' named entity 'interspecies transmission' named entity 'pathogenesis' named entity 'coronavirus' named entity 'serology' named entity 'vaccines' named entity 'trypsin' named entity 'cross reactions' named entity 'antibody' named entity 'enteritis' named entity 'DTH' named entity 'oral tolerance' named entity 'humoral' named entity 'FIP' named entity 'infection' named entity 'mutation'

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