About: Association of functional polymorphisms in the MxA gene with susceptibility to enterovirus 71 infection

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About: Association of functional polymorphisms in the MxA gene with susceptibility to enterovirus 71 infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Association of functional polymorphisms in the MxA gene with susceptibility to enterovirus 71 infection
Creator	Liu, Wei Li, Hao Zhang, Xiaoai Yang, Hong Cao, Wuchun Liu, Lijuan Zhang, Renli Zhuang, Lu Wang, · Zhang, · Cui, · Ding, Shujun Li, Tingyu Li, Xiujun Xiaodan, · Xu, Hongmei
source	Medline; PMC
abstract	Myxovirus resistance A (MxA) is an antiviral protein induced by type I interferons α and β (IFN-α and IFN-β) that can inhibit virus replication. We examined whether the MxA polymorphisms were related to the risk and severity of enterovirus 71 (EV71) infection in Chinese populations. The MxA C-123A and G-88T polymorphisms were genotyped in two independent case–control populations in China by polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) analysis. Multivariate logistic regression analysis was used to calculate adjusted odds ratios (ORs) and 95 % confidence intervals (95 % CIs). MxA messenger RNA was quantified by real-time quantitative PCR in peripheral blood mononuclear cells (PBMCs) from 45 healthy children and 19 patients with EV71 infection. Significantly decreased susceptibility to EV71 infection was observed for the -123A allele and -88T allele carriers, with ORs (95 % CIs) estimated as 0.56 (0.39–0.81) and 0.64 (0.47–0.88), respectively, in the northern population. This association was confirmed in the southern population, with ORs (95 % CIs) estimated as 0.58 (0.38–0.89) and 0.67(0.47–0.95), respectively. The A(-) (123)T(-) (88) haplotype was also significantly associated with lower risk of EV71 infection in both the northern (OR = 0.62; 95 % CI = 0.44–0.85) and the southern population (OR = 0.63; 95 % CI = 0.43–0.92). Furthermore, we observed higher MxA messenger RNA levels in IFNβ1a-stimulated PBMCs from the -123A or -88T allele carriers compared with that from nocarriers. Our findings suggest that polymorphisms in the MxA promoter may play a role in mediating the susceptibility to EV71 infection in Chinese population.
has issue date	2013-10-02(xsd:dateTime)
bibo:doi	10.1007/s00439-013-1367-3
bibo:pmid	24085612
has license	no-cc
sha1sum (hex)	745215601ff67cccdeb7294ae116243da8a8b29c
schema:url	https://doi.org/10.1007/s00439-013-1367-3
resource representing a document's title	Association of functional polymorphisms in the MxA gene with susceptibility to enterovirus 71 infection
has PubMed Central identifier	PMC7088390
has PubMed identifier	24085612
schema:publication	Hum Genet
resource representing a document's body	covid:745215601ff67cccdeb7294ae116243da8a8b29c#body_text
is schema:about of	named entity 'MXA' named entity 'POLYMORPHISMS' named entity 'gene' named entity 'ASSOCIATION' named entity 'ALLELE' named entity 'PBMCS' named entity 'OUR' named entity 'LEVELS' named entity 'COMPARED' named entity 'ORS' named entity 'CHINESE' named entity 'INFECTION' named entity 'POPULATION' named entity 'OBSERVED' named entity 'RISK OF' named entity 'ESTIMATED' named entity 'SUSCEPTIBILITY' named entity 'MESSENGER RNA' named entity 'HIGHER' named entity 'ASSOCIATED WITH' named entity 'CIS' named entity 'ASSOCIATION' named entity 'SUSCEPTIBILITY' named entity 'FUNCTIONAL' named entity 'GENE' named entity 'MEDIATING' named entity 'CONFIRMED' named entity 'ENTEROVIRUS 71 INFECTION' named entity 'ROLE' named entity 'MXA' named entity '0.63' named entity '0.85' named entity 'SOUTHERN' named entity 'CARRIERS' named entity 'PLAY' named entity 'HAPLOTYPE' named entity 'STIMULATED' named entity 'LOWER' named entity '0.67' named entity '0.58' named entity '0.92' named entity '0.44' named entity 'SUGGEST' named entity 'NORTHERN' named entity 'FINDINGS' named entity 'ZHANG' named entity 'IFN' named entity 'EV71' named entity 'PROMOTER' named entity 'PAPER' named entity 'POLYMORPHISMS' covid:arg/745215601ff67cccdeb7294ae116243da8a8b29c named entity 'paper' named entity 'allele' named entity 'haplotype' named entity 'MxA' named entity 'MxA' named entity 'PBMCs' named entity 'EV71' named entity 'MxA' named entity 'population' named entity 'infection' named entity 'PstI' named entity 'genotype' named entity 'infection' named entity 'MxA'

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