About: Characteristics and clinical significance of myocardial injury in patients with severe coronavirus disease 2019

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Characteristics and clinical significance of myocardial injury in patients with severe coronavirus disease 2019
Creator	Huang, He Yang, Bo Liu, Xu Yang, Fan Liu, Tao Cao, Sheng Shen, Bo Cai, Yuli Huang, Congxin Qin, Mu Shi, Shaobo Xiang, Yaozu Zhao, Qinyan
source	Medline; PMC
abstract	AIMS: To investigate the characteristics and clinical significance of myocardial injury in patients with severe coronavirus disease 2019 (COVID-19). METHODS AND RESULTS: We enrolled 671 eligible hospitalized patients with severe COVID-19 from 1 January to 23 February 2020, with a median age of 63 years. Clinical, laboratory, and treatment data were collected and compared between patients who died and survivors. Risk factors of death and myocardial injury were analysed using multivariable regression models. A total of 62 patients (9.2%) died, who more often had myocardial injury (75.8% vs. 9.7%; P < 0.001) than survivors. The area under the receiver operating characteristic curve of initial cardiac troponin I (cTnI) for predicting in-hospital mortality was 0.92 [95% confidence interval (CI), 0.87–0.96; sensitivity, 0.86; specificity, 0.86; P < 0.001]. The single cut-off point and high level of cTnI predicted risk of in-hospital death, hazard ratio (HR) was 4.56 (95% CI, 1.28–16.28; P = 0.019) and 1.25 (95% CI, 1.07–1.46; P = 0.004), respectively. In multivariable logistic regression, senior age, comorbidities (e.g. hypertension, coronary heart disease, chronic renal failure, and chronic obstructive pulmonary disease), and high level of C-reactive protein were predictors of myocardial injury. CONCLUSION: The risk of in-hospital death among patients with severe COVID-19 can be predicted by markers of myocardial injury, and was significantly associated with senior age, inflammatory response, and cardiovascular comorbidities.
has issue date	2020-05-11(xsd:dateTime)
bibo:doi	10.1093/eurheartj/ehaa408
bibo:pmid	32391877
has license	no-cc
sha1sum (hex)	745abcb681b9c9707cae376d260c819960179f8c
schema:url	https://doi.org/10.1093/eurheartj/ehaa408
resource representing a document's title	Characteristics and clinical significance of myocardial injury in patients with severe coronavirus disease 2019
has PubMed Central identifier	PMC7239100
has PubMed identifier	32391877
schema:publication	Eur Heart J
resource representing a document's body	covid:745abcb681b9c9707cae376d260c819960179f8c#body_text
is schema:about of	named entity 'coronavirus disease 2019' named entity 'myocardial injury' named entity 'extracorporeal membrane oxygenation' named entity 'oxygen saturation' named entity 'statistical bias' named entity 'Python' named entity 'Wuhan' named entity 'pneumonia' named entity 'inflammatory response' named entity 'IBM' named entity 'ARDS' named entity 'ARDS' named entity 'MYO' named entity 'real-time RT-PCR' named entity 'atherosclerotic plaques' named entity 'MYO' named entity 'ARDS' named entity 'COVID-19' named entity 'follow-up' named entity 'C-reactive protein' named entity 'inflammatory response' named entity 'teaching hospital' named entity 'isolation ward' named entity 'risk factors' named entity 'demographic characteristics' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'comorbidities' named entity 'higher risk' named entity 'MYO' named entity '0.01' named entity 'myocardial injury' named entity 'Wuhan University' named entity 'myocardial injury' named entity 'MYO' named entity 'acute respiratory failure' named entity 'kidney impairment' named entity 'N-terminal' named entity 'myocardial injury' named entity 'China' named entity 'Mann-Whitney U test' named entity 'comorbidities' named entity 'cardiovascular disease' named entity 'left ventricular' named entity 'biomarker' named entity 'COVID' named entity 'reference limit' named entity 'multiple organ failure' named entity '95% CI' named entity 'diabetes' named entity 'NT-proBNP' named entity 'antiviral treatment' named entity 'myocardial injury' named entity 'respiratory rate' named entity 'C-reactive protein' named entity 'mechanical ventilation' named entity 'biomarkers' named entity 'CK-MB' named entity 'older age' named entity 'mortality rate' named entity 'hypertension' named entity 'cardiac complications' named entity 'flowchart' named entity 'COVID' named entity 'China' named entity 'creatinine clearance' named entity 'myocardial injury' named entity 'organ failure' named entity 'SARS-CoV-2' named entity 'Fisher's exact test'

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