About: Overexpression of reactive oxygen species modulator 1 is associated with advanced grades of bladder cancer

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About: Overexpression of reactive oxygen species modulator 1 is associated with advanced grades of bladder cancer Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Overexpression of reactive oxygen species modulator 1 is associated with advanced grades of bladder cancer
Creator	Mohammad, · Alizamir, Aida Amini, Amin Azizi, · Ghasemi, Hadi Heidar Tayebinia, · Khanverdilou, Shima Mousavibahar, Habibollah Pegah, Atefeh Seyed, ·
source	Medline; PMC
abstract	Reactive Oxygen Species Modulator 1 (ROMO1) plays a pivotal role in the regulation of mitochondrial structure integrity, and the production of reactive oxygen species (ROS). Increased ROMO1 expression was reported in various cancer cell lines; however, the possible association between ROMO1 expression and bladder cancer was not well studied. The present study aimed to investigate the rate of ROMO1 expression and the correlation of oxidative stress with the development of bladder cancer. In this study, a total of 35 cancerous and healthy adjacent tissues were examined using quantitative real-time polymerase chain reaction (qRT-PCR) to analyze the gene expression of ROMO1. Also, we evaluated the serum level of ROMO1 and Total Antioxidant Capacity (TAC), as well as Total Oxidant Status (TOS) in patients with bladder cancer along with age- and sex-matched healthy individuals. The ROMO1 gene was significantly higher in cancerous tissues than that of adjacent healthy tissues. Also, the serum levels of ROMO1, TAC, TOS, and Oxidative Stress Index (OSI) were increased in patients with bladder cancer compared with healthy subjects. It can be concluded that the overexpression of the ROMO1 gene is associated with advanced grades of bladder cancer as well as an increase in oxidative stress conditions. Our findings also suggest that the serum level of ROMO1 might be a promising tumor marker for bladder cancer.
has issue date	2020-08-08(xsd:dateTime)
bibo:doi	10.1007/s11033-020-05702-1
bibo:pmid	32770525
has license	no-cc
sha1sum (hex)	7476ee0c7691104d6778b9a82adc3101d52803b2
schema:url	https://doi.org/10.1007/s11033-020-05702-1
resource representing a document's title	Overexpression of reactive oxygen species modulator 1 is associated with advanced grades of bladder cancer
has PubMed Central identifier	PMC7414271
has PubMed identifier	32770525
schema:publication	Mol Biol Rep
resource representing a document's body	covid:7476ee0c7691104d6778b9a82adc3101d52803b2#body_text
is schema:about of	named entity 'expression' named entity 'serum' named entity 'cancer cell' named entity 'pivotal' named entity 'modulator' named entity 'advanced' named entity 'FINDINGS' named entity 'STUDY' named entity 'HEALTHY SUBJECTS' named entity 'HEALTHY' named entity 'TOS' named entity 'LEVELS' covid:arg/7476ee0c7691104d6778b9a82adc3101d52803b2 named entity 'Status' named entity 'compared' named entity 'integrity' named entity 'reactive oxygen species (ROS)' named entity 'production' named entity 'serum' named entity 'oxidative stress' named entity 'Antioxidant' named entity 'mitochondrial' named entity 'Reactive Oxygen Species' named entity 'expression' named entity 'correlation' named entity 'serum levels' named entity 'bladder cancer' named entity 'positive correlation' named entity 'MAPK' named entity 'prognosis' named entity 'Denmark' named entity 'metabolic pathways' named entity 'ROS' named entity 'tumors' named entity 'chemotherapy' named entity 'Grade II' named entity 'wavelength' named entity 'Bioassay' named entity 'cDNA' named entity 'Germany' named entity 'histological' named entity 'mitochondrial DNA' named entity 'TAC' named entity 'serum concentrations' named entity 'bladder cancer' named entity 'NMIBC' named entity 'T-tests' named entity 'bladder carcinoma' named entity 'Real-time PCR' named entity 'Pearson correlation' named entity 'serum samples' named entity 'gene expression' named entity 'pathologist' named entity 'wavelength' named entity 'bladder cancer' named entity 'serum levels' named entity 'histopathological' named entity 'COVID-19' named entity 'serum levels' named entity 'homeostasis' named entity 'COVID-19' named entity 'NMIBC' named entity 'tap water' named entity 'Iran' named entity 'cancer cells' named entity 'Bladder cancer' named entity 'oxidative stress' named entity 'bladder cancer' named entity 'NF-kB' named entity 'inflammation' named entity 'free radical' named entity 'redox'

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