About: Modelling estimates of the burden of respiratory syncytial virus infection in children in the UK

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About: Modelling estimates of the burden of respiratory syncytial virus infection in children in the UK Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Modelling estimates of the burden of respiratory syncytial virus infection in children in the UK
Creator	Taylor, Sylvia Fleming, Douglas Webb, David Taylor, Robert Haguinet, François Logie, John Lustig, Roger Matias, Gonçalo Schuck-Paim, Cynthia
topic	covid:749db9b72be52f793ff21e695d3675138bf01923#this
Source	Medline; PMC
abstract	OBJECTIVE: The burden of respiratory syncytial virus (RSV) illness is not well characterised in primary care. We estimated the burden of disease attributable to RSV in children in the UK between 1995 and 2009. DESIGN: Time-series regression modelling. SETTING: A multiple linear regression model based on weekly viral surveillance (RSV and influenza, Public Health England), and controlled for non-specific seasonal drivers of disease, estimated the proportion of general practitioner (GP) episodes of care (counted as first visit in a series within 28 days; Clinical Practice Research Datalink, CPRD), hospitalisations (Hospital Episode Statistics, HES) and deaths (Office of National Statistics, ONS) attributable to RSV each season. PARTICIPANTS: Children 0–17 years registered with a GP in CPRD, or with a respiratory disease outcome in the HES or ONS databases. PRIMARY OUTCOME MEASURES: RSV-attributable burden of GP episodes, hospitalisations and deaths due to respiratory disease by age. RSV-attributable burden associated with selected antibiotic prescriptions. RESULTS: RSV-attributable respiratory disease in the UK resulted in an estimated 450 158 GP episodes, 29 160 hospitalisations and 83 deaths per average season in children and adolescents, with the highest proportions in children <6 months of age (14 441/100 000 population, 4184/100 000 and 6/100 000, respectively). In an average season, there were an estimated 125 478 GP episodes for otitis media and 416 133 prescriptions for antibiotics attributable to RSV. More GP episodes, hospitalisations and deaths from respiratory disease were attributable to RSV than to influenza in children under 5 years. CONCLUSIONS: The burden of RSV in children in the UK exceeds that of influenza. RSV in children and adolescents contributes substantially to GP office visits for a diverse range of illnesses, and was associated with an average 416 133 prescribed antibiotic courses per season. Effective antiviral treatments and preventive vaccines are urgently needed for the management of RSV infection in children. TRIAL REGISTRATION NUMBER: NCT01706302.
has issue date	2016-06-02(xsd:dateTime)
bibo:doi	10.1136/bmjopen-2015-009337
bibo:pmid	27256085
has license	cc-by-nc
sha1sum (hex)	749db9b72be52f793ff21e695d3675138bf01923
schema:url	https://doi.org/10.1136/bmjopen-2015-009337
resource representing a document's title	Modelling estimates of the burden of respiratory syncytial virus infection in children in the UK
has PubMed Central identifier	PMC4893852
has PubMed identifier	27256085
schema:publication	BMJ Open
resource representing a document's body	covid:749db9b72be52f793ff21e695d3675138bf01923#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/749db9b72be52f793ff21e695d3675138bf01923
is schema:about of	named entity 'HES' named entity 'BASED' named entity 'CHILDREN' named entity 'ILLNESS' named entity 'BURDEN OF DISEASE' named entity 'CLINICAL PRACTICE' named entity 'NON-SPECIFIC' named entity 'HOSPITALISATIONS' named entity 'ESTIMATED' named entity 'burden' named entity 'burden' named entity 'RSV' named entity 'National Statistics' named entity 'disease' named entity 'respiratory syncytial virus' named entity 'primary care' named entity 'burden of disease' named entity 'RSV' named entity 'RSV' named entity 'RSV' named entity 'respiratory syncytial virus' named entity 'GlaxoSmithKline Biologicals' named entity 'temperate climates' named entity 'data quality' named entity 'antibiotics' named entity 'peer reviewed' named entity 'Multiple regression' named entity 'viral infections' named entity 'gestational age' named entity 'antibiotics' named entity '1 July 1995' named entity 'epidemic' named entity 'influenza' named entity 'otitis media' named entity 'GlaxoSmithKline Biologicals' named entity 'CPRD' named entity 'bronchiolitis' named entity 'time series' named entity 'HES' named entity 'Statistical analyses' named entity 'RSV' named entity 'influenza' named entity 'RSV' named entity 'respiratory disease' named entity 'disease burden' named entity 'pneumococcal' named entity 'septicaemia' named entity 'health outcomes' named entity 'GSK' named entity 'prematurity' named entity 'infection' named entity 'RSV' named entity 'epidemics' named entity 'RSV' named entity 'RSV' named entity 'infectious agent' named entity 'influenza' named entity 'autocorrelation' named entity 'RSV' named entity 'pathogens' named entity 'CPRD' named entity 'statistical modelling' named entity 'RSV' named entity 'RSV' named entity 'influenza-like illness' named entity 'RSV' named entity 'influenza' named entity 'middle ear' named entity 'Influenza' named entity 'statistical modelling' named entity 'influenza'

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