About: Multiple biological functions and pharmacological effects of lycorine

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About: Multiple biological functions and pharmacological effects of lycorine Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Multiple biological functions and pharmacological effects of lycorine
Creator	Quansheng, Zhou Yang, Ping Zhifei, Cao
Source	Medline; PMC
abstract	Lycorine is the major active component from the amaryllidaceae family plant Lycoris radiate, a represent traditional Chinese medicinal herb, and is one of the typical alkaloids with pyrrolophenanthridine nucleus core. Lycorine has drawn great interest in medicinal field due to its divergent chemical structures and multiple biological functions, as well as pharmacological effects on various diseases. Accumulated evidence shows that lycorine not only possesses strong pharmacological effects on many diseases, including anti-leukemia, anti-tumor, anti-angiogenesis, anti-virus, anti-bacteria, anti-inflammation, and antimalaria, but also exerts many other biological functions, such as inhibition of acetylcholinesterase and topoisomerase, suppression of ascorbic acid biosynthesis, and control of circadian period length. Notably, lycorine exhibits its numerous pharmacological effects on various diseases with very low toxicity and mild side effects. The divergent chemical structures, multiple biological functions, and very low toxicity of lycorine imply that the agent is a potential drug candidate that warrants for further preclinical and clinic investigation.
has issue date	2013-08-24(xsd:dateTime)
bibo:doi	10.1007/s11426-013-4967-9
bibo:pmid	32215001
has license	no-cc
sha1sum (hex)	74ac6fdff4da9fbbff90efb35909fcdc8ded0a15
schema:url	https://doi.org/10.1007/s11426-013-4967-9
resource representing a document's title	Multiple biological functions and pharmacological effects of lycorine
has PubMed Central identifier	PMC7088923
has PubMed identifier	32215001
schema:publication	Sci China Chem
resource representing a document's body	covid:74ac6fdff4da9fbbff90efb35909fcdc8ded0a15#body_text
is schema:about of	named entity 'PHARMACOLOGICAL' named entity 'CHINA' named entity 'EFFECTS' named entity 'BIOLOGICAL FUNCTIONS' named entity 'CHEMISTRY' named entity 'LYCORINE' named entity 'MULTIPLE' named entity 'SCIENCE' named entity 'pharmacological' named entity 'lycorine' named entity 'lycorine' named entity 'topoisomerase inhibitor' named entity 'lycorine' named entity 'toxicological' named entity 'HIV-1' named entity 'melanoma' named entity 'Bmal1' named entity 'toxicity' named entity 'Brunsvigia' named entity 'anti-virus' named entity 'NRK' named entity 'kidney' named entity 'sprouting angiogenesis' named entity 'tumor cell' named entity 'lipopolysaccharide' named entity '5-hydroxytryptamine' named entity 'tumor cell' named entity 'molecular ring' named entity 'tumorigenesis' named entity 'oncogene' named entity 'metastasis' named entity 'topoisomerase' named entity 'free-radical' named entity 'melanoma' named entity 'gamma-lactone' named entity 'tumor' named entity 'blood vessels' named entity 'narciclasine' named entity 'hydrophobic interaction' named entity 'dose-dependent manner' named entity 'EV71' named entity 'sprouting angiogenesis' named entity 'lycorine' named entity 'viruses' named entity 'biosynthesis' named entity 'lycorine' named entity 'lycorine' named entity 'HeLa' named entity 'Acetylcholinesterase' named entity 'prognosis' named entity 'cell cycle' named entity 'Trichomonosis' named entity 'metastasis' named entity 'azomethine' named entity 'nude mice' named entity 'cell growth' named entity 'arthritis' named entity 'melanoma' named entity 'Lycorine' named entity 'cell surface' named entity 'vascular endothelial growth factor' named entity 'anti-parasite' named entity 'lycorine' named entity 'HL-60' named entity 'Lycorine' named entity 'pharmacological' named entity 'arsenic trioxide' named entity 'Aphis gossypii' named entity 'virus' named entity 'tumors' named entity 'tumor cells' named entity 'tumor growth' named entity 'cell proliferation' named entity 'tumor cells' named entity 'ovarian cancer' named entity 'hematological' named entity 'lycorine' named entity 'lycorine' named entity 'metastatic'

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