About: Membrane insertion of the three main membranotropic sequences from SARS-CoV S2 glycoprotein

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Membrane insertion of the three main membranotropic sequences from SARS-CoV S2 glycoprotein Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Membrane insertion of the three main membranotropic sequences from SARS-CoV S2 glycoprotein
Creator	Guillén, Jaime Villalaín, José Kinnunen, Paavo
Source	Elsevier; Medline; PMC
abstract	Abstract In order to complete the fusion process of SARS-CoV virus, several regions of the S2 virus envelope glycoprotein are necessary. Recent studies have identified three membrane-active regions in the S2 domain of SARS-CoV glycoprotein, one situated downstream of the minimum furin cleavage, which is considered the fusion peptide (SARSFP), an internal fusion peptide located immediately upstream of the HR1 region (SARSIFP) and the pre-transmembrane domain (SARSPTM). We have explored the capacity of these selected membrane-interacting regions of the S2 SARS-CoV fusion protein, alone or in equimolar mixtures, to insert into the membrane as well as to perturb the dipole potential of the bilayer. We show that the three peptides interact with lipid membranes depending on lipid composition and experiments using equimolar mixtures of these peptides show that different segments of the protein may act in a synergistic way suggesting that several membrane-active regions could participate in the fusion process of the SARS-CoV.
has issue date	2008-12-31(xsd:dateTime)
bibo:doi	10.1016/j.bbamem.2008.07.021
bibo:pmid	18721794
has license	els-covid
sha1sum (hex)	74cd7bd1e708a661871ffd0aeaf80c5744bace64
schema:url	https://doi.org/10.1016/j.bbamem.2008.07.021
resource representing a document's title	Membrane insertion of the three main membranotropic sequences from SARS-CoV S2 glycoprotein
has PubMed Central identifier	PMC7157930
has PubMed identifier	18721794
schema:publication	Biochimica et Biophysica Acta (BBA) - Biomembranes
resource representing a document's body	covid:74cd7bd1e708a661871ffd0aeaf80c5744bace64#body_text
is schema:about of	named entity 'MAIN' named entity 'order' named entity 'insertion' named entity 'MINIMUM' named entity 'DIPOLE' named entity 'REGIONS' named entity 'SARS-COV' named entity 'FUSION PEPTIDE' named entity 'ORDER' named entity 'BILAYER' named entity 'PTM' named entity 'SELECTED' named entity 'INSERT' named entity 'PROTEIN ' named entity 'ENVELOPE GLYCOPROTEIN' named entity 'REGION' named entity 'NECESSARY' named entity 'DOMAIN' named entity 'INTERNAL' named entity 'FUSION PROTEIN' named entity 'GLYCOPROTEIN' named entity 'FUSION' named entity 'IFP' named entity 'MIXTURES' named entity 'SARS-COV' named entity 'SEQUENCES' named entity 'MEMBRANE' named entity 'SYNERGISTIC' named entity 'IDENTIFIED' named entity 'INTERACT' named entity 'HR1' named entity 'EXPERIMENTS' named entity 'DIFFERENT' named entity 'HAVE' named entity 'POTENTIAL' named entity 'FURIN' named entity 'ACT' named entity 'COMPLETE' named entity 'ACTIVE' named entity 'CLEAVAGE' named entity 'MEMBRANE' named entity 'GLYCOPROTEIN' named entity 'RECENT' named entity 'PROCESS' named entity 'DOWNSTREAM' named entity 'VIRUS' named entity 'STUDIES' named entity 'USING' named entity 'PEPTIDES' named entity 'TRANSMEMBRANE DOMAIN' named entity 'LIPID COMPOSITION' named entity 'IMMEDIATELY' named entity 'CONSIDERED' named entity 'WAY' named entity 'THESE' named entity 'UPSTREAM' named entity 'SEGMENTS' named entity 'VIRUS ENVELOPE' named entity 'CAPACITY' named entity 'PRE' named entity 'INSERTION' covid:arg/74cd7bd1e708a661871ffd0aeaf80c5744bace64 named entity 'membranes' named entity 'protein' named entity 'mixtures' named entity 'peptides' named entity 'SARS-CoV' named entity 'lipid' named entity 'PTM' named entity 'fusion' named entity 'transmembrane domain' named entity 'virus envelope' named entity 'peptides' named entity 'SARS-CoV' named entity 'fusion protein' named entity 'conservative substitution' named entity 'peptide' named entity 'SARS-CoV' named entity 'peptide'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software