About: Higher incidence of acute respiratory distress syndrome in cardiac surgical patients with elevated serum procalcitonin concentration: a prospective cohort study

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About: Higher incidence of acute respiratory distress syndrome in cardiac surgical patients with elevated serum procalcitonin concentration: a prospective cohort study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Higher incidence of acute respiratory distress syndrome in cardiac surgical patients with elevated serum procalcitonin concentration: a prospective cohort study
Creator	Chen, Han Cheng, Zhang-Bo
Source	PMC
abstract	BACKGROUND: Inflammatory response is activated during cardiopulmonary bypass (CPB), which may lead to acute respiratory distress syndrome (ARDS) and procalcitonin (PCT) increases during this inflammatory response. The objective of the study was to validate whether patients with higher serum PCT concentrations have a higher incidence of ARDS. METHODS: The study was a prospective, single-center, observational cohort study. All patients who received cardiac surgery with CPB were screened for study eligibility. Patients were assigned to the PCT-elevated cohort or the control cohort according to serum PCT concentration on the first postoperative day with a cut-off value of 7.0 ng/mL. Patients were followed up until the 7th postoperative day. The primary endpoint was the incidence of ARDS, which was diagnosed according to the Berlin definition. RESULTS: A total of 296 patients were enrolled, 64 patients were assigned to the PCT-elevated cohort and 232 patients were assigned to the control cohort. PCT concentration was 16.23 ± 5.9 ng/mL in the PCT-elevated cohort, and 2.70 ± 1.43 ng/mL in the control cohort (p < 0.001). The incidence of ARDS was significantly higher in the PCT-elevated cohort than in the control cohort (21.9% versus 5.6%, p < 0.001). The incidence of moderate-to-severe ARDS was also significantly higher in the PCT-elevated cohort than in the control cohort (10.9% versus 0.4%, p < 0.001). The hazard ratio of ARDS at 7 days in the PCT-elevated cohort, as compared with the control cohort, was 6.8 (95% confidence interval 2.7 to 17.4). The hazard ratio of moderate-to-severe ARDS in the PCT-elevated cohort was 57.3 (95% confidence interval 10.4 to 316.3). The positive predictive value of PCT for ARDS and moderate-to-severe ARDS were 0.242 and 0.121, respectively; the negative predictive value of PCT for ARDS and moderate-to-severe ARDS were 0.952 and 1.0, respectively. CONCLUSION: Cardiac surgical patients with elevated PCT concentration have a higher incidence of ARDS. Elevated PCT may serve as a warning signal of postoperative ARDS in patients undergoing cardiac surgery with CPB. Study registration Chinese Clinical Trial Registry (ChiCTR-OCH-14005076)
has issue date	2020-03-30(xsd:dateTime)
bibo:doi	10.1186/s40001-020-00409-2
bibo:pmid	32228702
has license	cc-by
sha1sum (hex)	75190d522270846a04259d7eea0f6719c92af34b
schema:url	https://doi.org/10.1186/s40001-020-00409-2
resource representing a document's title	Higher incidence of acute respiratory distress syndrome in cardiac surgical patients with elevated serum procalcitonin concentration: a prospective cohort study
has PubMed Central identifier	PMC7106626
has PubMed identifier	32228702
schema:publication	Eur J Med Res
resource representing a document's body	covid:75190d522270846a04259d7eea0f6719c92af34b#body_text
is schema:about of	named entity 'serum' named entity 'acute respiratory distress syndrome' named entity 'procalcitonin' named entity 'BACKGROUND' named entity 'sensitive and specific' named entity 'IL-6' named entity 'ARDS' named entity 'regression analysis' named entity 'pulmonary diseases' named entity 'univariate analysis' named entity 'response' named entity 'higher' named entity 'higher' named entity 'PCT' named entity 'Inflammatory response' named entity 'cardiopulmonary bypass' named entity 'procalcitonin' named entity 'cardiac surgical' named entity 'statistical analysis' named entity 'ARDS' named entity 'confidence interval' named entity 'sample size' named entity 'BNP' named entity 'echocardiography' named entity 'proinflammatory' named entity 'elective surgery' named entity 'ARDS' named entity 'Interquartile range' named entity 'BNP' named entity 'ARDS' named entity 'ARDS' named entity 'B-type natriuretic peptide' named entity 'lung injury' named entity 'transfusion' named entity 'ARDS' named entity 'ARDS' named entity 'ng/mL' named entity 'Clinical Trial' named entity 'ARDS' named entity 'acute lung injury' named entity 'ng/mL' named entity 'pulmonary edema' named entity 'fluid overload' named entity 'ARDS' named entity 'cardiac surgery' named entity '17.4' named entity 'transfusion' named entity 'neurological dysfunction' named entity 'significant difference' named entity 'SPSS' named entity 'statistical power' named entity 'ARDS' named entity 'ICU' named entity 'gastrointestinal tract' named entity 'systemic inflammatory response' named entity 'fluid balance' named entity 'ng/mL' named entity 'serum' named entity 'ARDS' named entity 'cardiac surgery' named entity 'IBM Corporation' named entity 'ARDS' named entity 'assay' named entity 'interleukin (IL)-6' named entity 'tumor necrosis factor' named entity 'C-reactive protein' named entity 'New York, USA' named entity 'Vasoactive' named entity 'renal failure' named entity 'B-type natriuretic peptide' named entity 'serum' named entity 'ARDS' named entity 'PCT' named entity 'serum' named entity 'chronic obstructive pulmonary disease' named entity 'Student's t-test' named entity 'ARDS' named entity 'blood gas analysis' named entity 'cut-off' named entity 'procalcitonin'

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