About: Comparison of xTAG Respiratory Virus Panel and Verigene Respiratory Virus Plus for Detecting Influenza Virus and Respiratory Syncytial Virus

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About: Comparison of xTAG Respiratory Virus Panel and Verigene Respiratory Virus Plus for Detecting Influenza Virus and Respiratory Syncytial Virus Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Comparison of xTAG Respiratory Virus Panel and Verigene Respiratory Virus Plus for Detecting Influenza Virus and Respiratory Syncytial Virus
Creator	Han, Minsuk Song, Junghan Kim, Eui Kim, Taek Lee, Hye Park, Kyoung Song, Eun Hong, Yun Hwang, Sang Lim, Mi
Source	PMC
abstract	BACKGROUND: Nucleic acid amplification tests have allowed simultaneous detection of multiple respiratory viruses. METHODS: We compared the results of a liquid bead array xTAG Respiratory Virus Panel (RVP; (Luminex Corporation, Toronto, Canada) and a solid microarray Verigene Respiratory Virus Plus (RV+; Nanosphere, Northbrook, IL) for the detection of influenza A virus (INF A), influenza B virus (INF B), and respiratory syncytial virus (RSV) in 170 respiratory specimens from hospitalized patients. RESULTS: Overall, xTAG RVP demonstrated sensitivities and specificities of 97.6 and 100% for INF A, 100 and 99.4% for INF B, and 100 and 100% for RSV, while the Verigene RV+ test sensitivities and specificities were 95.1 and 98.5%, 100.0 and 99.4%, and 97.1 and 100%, respectively. There were no significant differences in the area under the curves between the two assays for each virus (P = 0.364 for INF A, P = 1.000 for INF B, P = 0.317 for RSV). Comparing the results of two assays, discordant results were present mostly due to subtype assignments and identification of coinfections. The detection of viruses was not significantly different (P = 1.000) and the virus/subtype assignment showed good agreement with kappa coefficients of 0.908. CONCLUSION: The xTAG RVP and Verigene RV+ showed high sensitivities and specificities, and good overall agreement in detection and identification of INF and RSV. These assays can be used in clinical settings for a reliable detection of respiratory viruses found commonly in hospitalized patients.
has issue date	2014-05-05(xsd:dateTime)
bibo:doi	10.1002/jcla.21738
bibo:pmid	24796703
has license	green-oa
sha1sum (hex)	75213ed678ea6e124b6adc412f503b6a6db13c1c
schema:url	https://doi.org/10.1002/jcla.21738
resource representing a document's title	Comparison of xTAG Respiratory Virus Panel and Verigene Respiratory Virus Plus for Detecting Influenza Virus and Respiratory Syncytial Virus
has PubMed Central identifier	PMC6807105
has PubMed identifier	24796703
schema:publication	Journal of Clinical Laboratory Analysis
resource representing a document's body	covid:75213ed678ea6e124b6adc412f503b6a6db13c1c#body_text
is schema:about of	named entity 'RESPIRATORY' named entity 'SIMULTANEOUS' named entity 'CANADA' named entity 'HAVE' named entity 'Luminex Corporation' named entity 'Nucleic acid amplification tests' named entity 'Canada' named entity 'RSV' named entity 'Respiratory Syncytial Virus' named entity 'Influenza Virus' named entity 'Virus' named entity 'coinfection' named entity 'sensitivities and specificities' named entity 'sensitivities and specificities' named entity 'virus' named entity 'ROC' named entity 'viruses' named entity 'RT-PCR' named entity 'statistically significant' named entity 'pathogens' named entity 'gold nanoparticle' named entity 'viruses' named entity 'Luminex Corporation' named entity 'Mariakerke' named entity 'viruses' named entity 'multiplex reactions' named entity 'viruses' named entity 'kappa coefficient' named entity 'Canada' named entity 'Toronto' named entity 'false-positive result' named entity 'area under the curve' named entity '1.000' named entity 'Korea' named entity 'viruses' named entity 'hybridization' named entity 'MedCalc' named entity 'microliters' named entity 'respiratory infections' named entity 'viruses' named entity 'bioMérieux' named entity 'outpatient' named entity 'virus' named entity 'virus' named entity 'RT-PCR' named entity 'bronchoalveolar lavage fluid' named entity 'positive or negative' named entity 'Nucleic acids' named entity 'viruses' named entity 'false-positive' named entity 'RSV' named entity 'Viral infections' named entity 'viral pathogens' named entity 'sensitivity and specificity' named entity 'viruses' named entity 'Coinfection' named entity 'significant difference' named entity 'viral culture' named entity 'viruses' named entity 'microarray' named entity 'respiratory infections' named entity 'respiratory tract infections' named entity 'RT-PCR' named entity 'RSV' named entity 'viruses' named entity 'virus' named entity 'respiratory viral infections' named entity 'RSV' named entity 'respiratory syncytial virus' named entity 'viruses' named entity 'microarray' named entity 'viruses'

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