About: H2 influenza A virus is not pathogenic in Tmprss2 knock-out mice

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	H2 influenza A virus is not pathogenic in Tmprss2 knock-out mice
Creator	Pöhlmann, Stefan Gärtner, Sabine Winkler, Michael Nehlmeier, Inga Gerhauser, Ingo Kollmus, Heike Schughart, Klaus Leist, Sarah Lambertz, Olga Lydia, Ruth
Source	PMC
abstract	The host cell protease TMPRSS2 cleaves the influenza A virus (IAV) hemagglutinin (HA). Several reports have described resistance of Tmprss2(−/−) knock-out (KO) mice to IAV infection but IAV of the H2 subtype have not been examined yet. Here, we demonstrate that TMPRSS2 is able to cleave H2-HA in cell culture and that Tmprss2(−/−) mice are resistant to infection with a re-assorted PR8_HA(H2) virus. Infection of KO mice did not cause major body weight loss or death. Furthermore, no significant increase in lung weights and no virus replication were observed in Tmprss2(−/−) mice. Finally, only minor tissue damage and infiltration of immune cells were detected and no virus-positive cells were found in histological sections of Tmprss2(−/−) mice. In summary, our studies indicate that TMPRSS2 is required for H2 IAV spread and pathogenesis in mice. These findings extend previous results pointing towards a central role of TMPRSS2 in IAV infection and validate host proteases as a potential target for antiviral therapy.
has issue date	2020-04-22(xsd:dateTime)
bibo:doi	10.1186/s12985-020-01323-z
bibo:pmid	32321537
has license	cc-by
sha1sum (hex)	752ef5a274cd1951d1b1d103511a647ba054a9d9
schema:url	https://doi.org/10.1186/s12985-020-01323-z
resource representing a document's title	H2 influenza A virus is not pathogenic in Tmprss2 knock-out mice
has PubMed Central identifier	PMC7178614
has PubMed identifier	32321537
schema:publication	Virol J
resource representing a document's body	covid:752ef5a274cd1951d1b1d103511a647ba054a9d9#body_text
is schema:about of	named entity 'PR8' named entity 'PROTEASES' named entity 'TARGET' named entity 'DETECTED' named entity 'HOST' named entity 'OBSERVED' named entity 'HERE' named entity 'PREVIOUS' named entity 'BUT' named entity 'RESISTANCE' named entity 'HEMAGGLUTININ' named entity 'histological sections' named entity 'IAV' named entity 'mice' named entity 'infection' named entity 'host cell' named entity 'lung' named entity 'knock-out mice' named entity 'antibody' named entity 'TMPRSS2' named entity 'alveolar' named entity 'nucleoprotein' named entity 'C57BL/6' named entity 'virus' named entity 'bronchoalveolar lavage' named entity 'TMPRSS2' named entity 'Tmprss2' named entity 'serum' named entity 'lung' named entity 'mice' named entity 'nuclear protein' named entity 'virus' named entity 'mice' named entity 'mice' named entity 'viral particles' named entity 'wild type' named entity 'lung' named entity 'white blood cells' named entity 'weight loss' named entity 'sequencing library' named entity 'Tmprss2' named entity 'antibodies' named entity 'hematologic' named entity 'virus' named entity 'mice' named entity 'H1N1' named entity 'macrophages' named entity 'mice' named entity 'lumina' named entity 'FujiFilm' named entity 'intranasally' named entity 'antigen' named entity 'ffu' named entity 'bronchiolar epithelium' named entity 'antigen' named entity 'Tmprss2' named entity 'IAV' named entity 'ImageJ' named entity 'viral particles' named entity 'cellular receptors' named entity 'mice' named entity 'lymphocytes' named entity 'Lungs' named entity 'mice' named entity 'lung' named entity 'Robert Webster' named entity 'Tmprss2' named entity 'mononuclear cells' named entity 'infection' named entity 'immunohistochemically' named entity 'hematologic' named entity 'murine'

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