About: Immunohistochemical localization of components of the immune barrier in the olfactory mucosae of salamanders and rats

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About: Immunohistochemical localization of components of the immune barrier in the olfactory mucosae of salamanders and rats Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Immunohistochemical localization of components of the immune barrier in the olfactory mucosae of salamanders and rats
Creator	Getchell, Marilyn Getchell, Thomas
Source	PMC
abstract	Immunohistochemical techniques were used to investigate the cellular distribution of components of the secretory immune system, including secretory immunoglobulin, secretory piece, and J chain, as well as other immunoglobulins and nonspecific defense factors in the olfactory mucosae of salamanders and rats. In the salamander, secretory immunoglobulin M, and J chain were localized in duct and acinar cells of Bowman's glands, in B lymphocytes, and in sustentacular cells in immature regions of the olfactory mucosa. Lactoferrin and lysozyme were also present in Bowman's glands, in sustentacular cells in immature regions of the olfactory mucosa, and in blood cells in the lamina propria. Olfactory nerve section resulted in the presence of increased numbers of secretory immunoglobulin‐immunoreactive B lymphocytes and in an altered distribution of IgM, secretory piece, and lactoferrin. In the rat, secretory immunoglobulin A and J chain were localized in duct and acinar cells of Bowman's glands and in B lymphocytes in the lamina propria. Secretory piece could be demonstrated in Bowman's glands only in rats that had a prior viral infection. Other defense factors, localized in the lamina propria, included IgG in the connective tissue stroma and in B lymphocytes, IgD‐immunore‐active B lymphocytes, and IgE‐immunoreactive cells that were identified as mucosal mast cells. Lactoferrin and lysozyme were present in serous acinar cells of Bowman's glands and in blood cells. These results demonstrate that the olfactory mucosa is protected from pathogenic invasion by the secretory immune system as well as other immunoglobulins, lactoferrin, and lysozyme.
has issue date	2005-02-08(xsd:dateTime)
bibo:doi	10.1002/ar.1092310310
bibo:pmid	1763818
has license	no-cc
sha1sum (hex)	75e29a1aa7c466c0964f90e65e685759501707f7
schema:url	https://doi.org/10.1002/ar.1092310310
resource representing a document's title	Immunohistochemical localization of components of the immune barrier in the olfactory mucosae of salamanders and rats
has PubMed Central identifier	PMC7159625
has PubMed identifier	1763818
schema:publication	Anat Rec
resource representing a document's body	covid:75e29a1aa7c466c0964f90e65e685759501707f7#body_text
is schema:about of	named entity 'Olfactory' named entity 'immune system' named entity 'mucosae' named entity 'salamanders' named entity 'Olfactory' named entity 'Mucosae' named entity 'lymphocytes' named entity 'olfactory nerve' named entity 'rat' named entity 'nuclei' named entity 'secretion' named entity 'immunocyte' named entity 'J chain' named entity 'immunoreactive' named entity 'Alcian blue' named entity 'Alcian blue' named entity 'immunoreactive' named entity 'Antibodies' named entity 'J chain' named entity 'Sprague-Dawley' named entity 'blood cells' named entity 'nasal glands' named entity 'lymphocytes' named entity 'acini' named entity 'Charles River Laboratories' named entity 'parotid gland' named entity 'rat' named entity 'nuclei' named entity 'respiratory mucosa' named entity 'IgA' named entity 'olfactory nerve' named entity 'respiratory mucosa' named entity 'olfactory' named entity 'IgE' named entity 'tricaine methanesulfonate' named entity 'IgD' named entity 'Bowman's gland' named entity 'secondary antibody' named entity 'mucosae' named entity 'mast cells' named entity 'Sustentacular cells' named entity 'olfactory nerve' named entity 'IgM' named entity 'olfactory epithelium' named entity 'colostrum' named entity 'IgG' named entity 'lymphocytes' named entity 'signs of infection' named entity 'plasma cells' named entity 'secretory granules' named entity 'stroma' named entity 'mast cells' named entity 'Immunoreactivity' named entity 'lymphocytes' named entity 'lamina propria' named entity 'mucosa' named entity 'salivary gland' named entity 'TRITC' named entity 'mucosae' named entity 'olfactory mucosa' named entity 'Bowman's gland' named entity 'olfactory bulb' named entity 'Sustentacular cells' named entity 'rat' named entity 'immunoreactive' named entity 'antibody' named entity 'polyclonal antibodies' named entity 'lysozyme' named entity 'immunohistochemical' named entity 'immunoreactive' named entity 'co-expression' named entity 'lymphocytes' named entity 'molecular-weight' named entity 'lumen' named entity 'acinar cells' named entity 'IgA' named entity 'antibodies' named entity 'IgG' named entity 'immunoreactive' named entity 'immunoreactive'

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