About: The structure-based reaction mechanism of urease, a nickel dependent enzyme: tale of a long debate

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The structure-based reaction mechanism of urease, a nickel dependent enzyme: tale of a long debate
Creator	Ciurli, Stefano Mazzei, Luca Musiani, Francesco
Source	Medline; PMC
abstract	This review is an attempt to retrace the chronicle that starts from the discovery of the role of nickel as the essential metal ion in urease for the enzymatic catalysis of urea, a key step in the biogeochemical cycle of nitrogen on Earth, to the most recent progress in understanding the chemistry of this historical enzyme. Data and facts are presented through the magnifying lenses of the authors, using their best judgment to filter and elaborate on the many facets of the research carried out on this metalloenzyme over the years. The tale is divided in chapters that discuss and describe the results obtained in the subsequent leaps in the knowledge that led from the discovery of a biological role for Ni to the most recent advancements in the comprehension of the relationship between the structure and function of urease. This review is intended not only to focus on the bioinorganic chemistry of this beautiful metal-based catalysis, but also, and maybe primarily, to evoke inspiration and motivation to further explore the realm of bio-based coordination chemistry.
has issue date	2020-08-18(xsd:dateTime)
bibo:doi	10.1007/s00775-020-01808-w
bibo:pmid	32809087
has license	cc-by
sha1sum (hex)	75ec80cae8e8cd9b8e23dcdae389573551909435
schema:url	https://doi.org/10.1007/s00775-020-01808-w
resource representing a document's title	The structure-based reaction mechanism of urease, a nickel dependent enzyme: tale of a long debate
has PubMed Central identifier	PMC7433671
has PubMed identifier	32809087
schema:publication	J Biol Inorg Chem
resource representing a document's body	covid:75ec80cae8e8cd9b8e23dcdae389573551909435#body_text
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