About: Field Efficacy of an Attenuated Infectious Bronchitis Variant 2 Virus Vaccine in Commercial Broiler Chickens

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About: Field Efficacy of an Attenuated Infectious Bronchitis Variant 2 Virus Vaccine in Commercial Broiler Chickens Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Field Efficacy of an Attenuated Infectious Bronchitis Variant 2 Virus Vaccine in Commercial Broiler Chickens
Creator	Ali, Ahmed Ibrahim, Hytham Nabil, Ahmed Samir, Ahmed Elfeil, Wael Elhady, Mohamed Kilany, Walid Sayed, Magdy
Source	Medline; PMC
abstract	Egyptian poultry suffer from frequent respiratory disease outbreaks associated with Infectious Bronchitis Virus (IBV) variant 2 strains (Egy/VarII). Different vaccination programs using imported vaccines have failed to protect the flocks from field challenge. Recent studies confirmed a successful protection using homologous strains as live attenuated vaccines. In this study, a newly developed live attenuated IB-VAR2 vaccine representing the GI-23 Middle East IBV lineage was evaluated in day-old commercial broilers in an IBV-endemic area. A commercial broiler flock was vaccinated with the IB-VAR2 vaccine at day-old age followed by IB-H120 at day 16. The vaccinated flock was monitored on a weekly basis till the slaughter age. The health status and growth performance were monitored, and selected viral pathogen real-time RT-PCR (rRT-PCR) detection was conducted on a weekly basis. Finally, the flock was compared to a nearby farm with only the classical IB-H120 vaccination program. Results showed that the IB-VAR2 vaccine was tolerable in day-old broiler chicks. The IBV virus rRT-PCR detection was limited to the trachea as compared to its nephropathogenic parent virus. Respiratory disease problems and high mortalities were reported in the IB-H120-only vaccinated flock. An exposure to a wild-type Egy/VarII strain was confirmed in both flocks as indicated by partial IBV S1 gene sequence. Even though the IB-VAR2-vaccinated flock performance was better than the flock that received only IB-H120, the IBV ELISA (enzyme-linked immunosorbent assay) and log2 Haemagglutination inhibition (HI) antibody mean titers remained high (3128 ± 2713 and ≥9 log2, respectively) until the 28th day of age. The current study demonstrates the safety and effectiveness of IB-VAR2 as a live attenuated vaccine in day-old commercial broilers. Also, the combination of IB-VAR2 and classical IBV vaccines confers a broader protective immune response against IBV in endemic areas.
has issue date	2018-05-09(xsd:dateTime)
bibo:doi	10.3390/vetsci5020049
bibo:pmid	29747397
has license	cc-by
sha1sum (hex)	7633ee09c0059b99608c1cfbeefd19775c0317ff
schema:url	https://doi.org/10.3390/vetsci5020049
resource representing a document's title	Field Efficacy of an Attenuated Infectious Bronchitis Variant 2 Virus Vaccine in Commercial Broiler Chickens
has PubMed Central identifier	PMC6024885
has PubMed identifier	29747397
schema:publication	Vet Sci
resource representing a document's body	covid:7633ee09c0059b99608c1cfbeefd19775c0317ff#body_text
is schema:about of	named entity 'performance' named entity 'monitored' named entity 'strain' named entity 'respiratory disease' named entity 'received' named entity 'BROILER' named entity 'VIRUS VACCINE' named entity 'S1 GENE' named entity 'LOG2' named entity 'MONITORED' named entity 'ANTIBODY' named entity 'TILL' named entity 'PARTIAL' named entity 'ATTENUATED' named entity 'BASIS' named entity 'CLASSICAL' named entity 'PARENT' named entity 'BETTER' named entity 'STRAIN' named entity 'GROWTH PERFORMANCE' named entity 'CHICKS' named entity 'AREA' named entity 'LIMITED' named entity 'VARIANT' named entity 'AGE' named entity 'LIVE ATTENUATED VACCINE' named entity 'FAILED' named entity 'ATTENUATED VACCINES' named entity 'IMMUNE RESPONSE' named entity 'PROTECTION' named entity 'CONFIRMED' named entity 'STUDIES' named entity 'MORTALITIES' named entity 'SUCCESSFUL' named entity 'TRACHEA' named entity 'DAY' named entity 'NEARBY' named entity 'CHALLENGE' named entity 'HOMOLOGOUS' named entity 'ITS' named entity 'ASSOCIATED WITH' named entity 'COMMERCIAL' named entity 'A59' named entity 'EVALUATED' named entity 'INDICATED' named entity 'PROBLEMS' named entity 'STUDY' named entity 'FIELD' named entity 'STRAINS' named entity 'FOLLOWED BY' named entity 'COMBINATION' named entity 'BROILER' named entity 'CHICKENS' named entity 'WILD-TYPE' named entity 'COMPARED' named entity 'RRT-PCR' named entity 'VACCINATION PROGRAM' named entity 'ENDEMIC' named entity 'EGYPTIAN' named entity 'PROGRAMS' named entity 'IMPORTED' named entity 'INFECTIOUS BRONCHITIS' named entity 'VARIANT' named entity 'HEALTH STATUS' named entity 'SUFFER' named entity 'USING' named entity 'ATTENUATED' named entity 'COMMERCIAL' named entity 'FIELD' named entity 'POULTRY' named entity 'HAEMAGGLUTINATION INHIBITION' named entity 'HAVE' named entity 'VACCINE' named entity 'DETECTION'

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