About: Altered Gut Microbiota Profiles in Sows and Neonatal Piglets Associated with Porcine Epidemic Diarrhea Virus Infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Altered Gut Microbiota Profiles in Sows and Neonatal Piglets Associated with Porcine Epidemic Diarrhea Virus Infection
Creator	Ye, Yu Wang, Leyi Chen, Yanjun Huang, Dongyan Peng, Qi Song, Deping Tang, Yuxin Zhang, Fanfan Zhou, Xinrong Wu, Qiong Li, Anqi He, Houjun
source	Medline; PMC
abstract	Porcine epidemic diarrhea virus (PEDV) is a devastating cause of diarrhea in pigs worldwide. Most of studies have focused on molecular and pathogenic characterization of PEDV, whereas there were limited studies in understanding the role of gut microbiota (GM) in viral-associated diarrhea. Here, using the Illumina MiSeq platform, we examined and compared the impact of PEDV infection on the GM of sows and their piglets less than 10 days old. Our results showed that PEDV caused alternations in the structure and abundance of GM from levels of phylum to genus, and even species. For sows, a significant decrease of observed species was found in diarrheal sows than that in healthy sows (p < 0.05). The unweighted and weighted UniFrac distances also revealed considerable segregations of GM structure among healthy, asymptomatic, and diarrheal sows. For piglets, Bacteroidetes, the dominant bacteria in healthy piglets, were replaced by Firmicutes in asymptomatic and diarrheal piglets. The abundances of Fusobacteria and Proteobacteria were also remarkably increased in asymptomatic piglets and diarrheal piglets when compared to those of the healthy piglets. Our findings demonstrated that PEDV infection caused severe perturbations of GM, reduced probiotic bacteria, and enriched pathogenic bacteria.
has issue date	2017-12-12(xsd:dateTime)
bibo:doi	10.1038/s41598-017-17830-z
bibo:pmid	29234140
has license	cc-by
sha1sum (hex)	76585719cd2c0b067b878acf53964015a47bb917
schema:url	https://doi.org/10.1038/s41598-017-17830-z
resource representing a document's title	Altered Gut Microbiota Profiles in Sows and Neonatal Piglets Associated with Porcine Epidemic Diarrhea Virus Infection
has PubMed Central identifier	PMC5727058
has PubMed identifier	29234140
schema:publication	Sci Rep
resource representing a document's body	covid:76585719cd2c0b067b878acf53964015a47bb917#body_text
is schema:about of	named entity 'ASSOCIATED WITH' named entity 'levels' named entity 'piglets' named entity 'For' named entity 'abundances' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'ABUNDANCE' named entity 'OLD' named entity 'SPECIES' named entity 'GENUS' named entity 'LEVELS' named entity 'BACTERIA' named entity 'OBSERVED' named entity 'FINDINGS' named entity 'VIRAL-' named entity 'HAVE' named entity 'UNDERSTANDING' named entity 'PROTEOBACTERIA' named entity 'ENRICHED' named entity 'ASSOCIATED' named entity 'INCREASED' named entity 'ASYMPTOMATIC' named entity 'PROBIOTIC' named entity 'OUR' named entity 'DOMINANT' named entity 'SEGREGATIONS' named entity 'EXAMINED' named entity 'REPLACED BY' named entity '28P' named entity 'THEIR' named entity 'FUSOBACTERIA' named entity 'DAYS' named entity 'FOCUSED' named entity 'BACTERIA ' named entity 'MOST OF' named entity 'PATHOGENIC BACTERIA' named entity 'ILLUMINA MISEQ' named entity 'REDUCED' named entity 'NEONATAL' named entity 'ALTERED' named entity 'SIGNIFICANT' named entity 'HEALTHY' named entity 'FIRMICUTES' named entity 'GUT MICROBIOTA' named entity '0.05' named entity 'PHYLUM' named entity 'BACTEROIDETES' named entity 'SOWS' named entity 'CHARACTERIZATION' named entity 'SOWS' named entity 'VIRUS INFECTION' named entity 'OPEN' named entity 'STRUCTURE' named entity 'ROLE' named entity 'LIMITED' named entity 'DECREASE' named entity 'SEVERE' named entity 'MOLECULAR' named entity 'BACTERIA.' named entity 'CAUSED' named entity 'IMPACT' named entity 'PATHOGENIC' named entity 'DIARRHEA' named entity 'STUDIES' named entity 'LESS THAN' named entity 'PEDV' named entity 'GUT MICROBIOTA' named entity 'DISTANCES' named entity 'PLATFORM' named entity 'WEIGHTED'

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