About: Anti-cytokine autoantibodies in postherpetic neuralgia

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Anti-cytokine autoantibodies in postherpetic neuralgia
Creator	Breuer, Judith Burbelo, Peter Cohen, Jeffrey Iadarola, Michael Browne, Sarah Bayat, Ahmad Buvanendran, Asokumar Holland, Steven Kroin, Jeffrey Mannes, Andrew Martinez, Bianca Quinlivan, Mark
Source	PMC
abstract	BACKGROUND: The mechanisms by which varicella zoster virus (VZV) reactivation causes postherpetic neuralgia (PHN), a debilitating chronic pain condition, have not been fully elucidated. Based on previous studies identifying a causative role for anti-cytokine autoantibodies in patients with opportunistic infections, we explored this possibility in PHN. METHODS: Sera from herpes zoster (HZ) patients without and with PHN (N = 115 and 83, respectively) were examined for the presence of autoantibodies against multiple cytokines, and other known autoantigens. In addition, a cohort of patients with complex regional pain syndrome or neuropathic pain was tested for autoantibodies against selected cytokines. Antibody levels against VZV, Epstein Barr virus, and herpes simplex virus-2 were also measured in the HZ and PHN patients. Patient sera with high levels of anti-cytokine autoantibodies were functionally tested for in vitro neutralizing activity. RESULTS: Six PHN subjects demonstrated markedly elevated levels of single, autoantibodies against interferon-α, interferon-γ, GM-CSF, or interleukin-6. In contrast, the HZ and the pain control group showed low or no autoantibodies, respectively, against these four cytokines. Further analysis revealed that one PHN patient with high levels of anti-interleukin-6 autoantibodies had a markedly depressed antibody level to VZV, potentially reflecting poor T cell immunity against VZV. In vitro functional testing revealed that three of the five anti-cytokine autoantibody positive PHN subjects had neutralizing autoantibodies against interferon-α, GM-CSF or interleukin-6. In contrast, none of the HZ patients without PHN had neutralizing autoantibodies. CONCLUSIONS: These results suggest the possibility that sporadic anti-cytokine autoantibodies in some subjects may cause an autoimmune immunodeficiency syndrome leading to uncontrolled VZV reactivation, nerve damage and subsequent PHN.
has issue date	2015-10-20(xsd:dateTime)
bibo:doi	10.1186/s12967-015-0695-6
bibo:pmid	26482341
has license	cc-by
sha1sum (hex)	76681fffce58a9c3e3c125f37c40ed5388b97a30
schema:url	https://doi.org/10.1186/s12967-015-0695-6
resource representing a document's title	Anti-cytokine autoantibodies in postherpetic neuralgia
has PubMed Central identifier	PMC4617715
has PubMed identifier	26482341
schema:publication	J Transl Med
resource representing a document's body	covid:76681fffce58a9c3e3c125f37c40ed5388b97a30#body_text
is schema:about of	named entity 'VZV' covid:arg/76681fffce58a9c3e3c125f37c40ed5388b97a30 named entity 'studies' named entity 'PHN' named entity 'PHN' named entity 'PHN' named entity 'PHN' named entity 'autoantibodies' named entity 'autoantibodies' named entity 'RNP' named entity 'cytokine' named entity 'PHN' named entity 'Luciferase' named entity 'autoantibodies' named entity 'GM-CSF' named entity 'VZV' named entity 'Serum' named entity 'postherpetic neuralgia' named entity 'seropositivity' named entity 'IL-12' named entity 'PHN' named entity 'RNP' named entity 'flow cytometry' named entity 'IFN-γ' named entity 'autoantibody' named entity 'cytokine' named entity 'autoantibodies' named entity 'varicella-zoster virus' named entity 'autoantibody' named entity 'phosphorylation' named entity 'PHN' named entity 'VZV' named entity 'CRPS' named entity 'PHN' named entity 'thymoma' named entity 'PHN' named entity 'seronegative' named entity 'autoimmune' named entity 'PHN' named entity 'autoantibodies' named entity 'antigens' named entity 'IL-6' named entity 'IL-12' named entity 'autoantibodies' named entity 'VZV' named entity 'IFN' named entity 'vesicular' named entity 'IFN-γ' named entity 'blood donors' named entity 'ARDS' named entity 'autoantibodies' named entity 'Research Ethics Committee' named entity 'autoantibodies' named entity 'autoantibodies' named entity 'anticytokine' named entity 'antibodies' named entity 'GM-CSF' named entity 'lymphocytes' named entity 'VZV' named entity 'antibodies' named entity 'septic shock' named entity 'macrophages' named entity 'autoantibodies' named entity 'Chronic pain' named entity 'autoantibodies' named entity 'central sensitization' named entity 'HSV-2' named entity 'infection' named entity 'PHN' named entity 'IFN-γ'

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