About: Age- and gender-related difference of ACE2 expression in rat lung

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About: Age- and gender-related difference of ACE2 expression in rat lung Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Age- and gender-related difference of ACE2 expression in rat lung
Creator	Furong, Zhang Junzhu, Chen Xingxiang, Wang Xudong, Xie Yanrong, Liu
Source	Elsevier; Medline; PMC
abstract	Abstract Epidemiologic data suggested that there was an obvious predominance of young adult patients with a slight female proneness in severe acute respiratory syndrome (SARS). The angiotensin-converting enzyme 2 (ACE2) was very recently identified as a functional receptor for SARS virus and is therefore a prime target for pathogenesis and pharmacological intervention. Rats of both genders at three distinct ages (young-adult, 3 months; middle-aged, 12 months; old, 24 months) were evaluated to determine the characteristic of ACE2 expression in lung and the effect of aging and gender on its expression. ACE2 was predominantly expressed in alveolar epithelium, bronchiolar epithelium, endothelium and smooth muscle cells of pulmonary vessels with similar content, whereas no obvious signal was detected in the bronchiolar smooth muscle cells. ACE2 expression is dramatically reduced with aging in both genders: young-adult vs. old P <0.001 (by 78% in male and 67% in female, respectively) and middle-aged vs. old P <0.001 (by 71% in male rats and 59% in female rats, respectively). The decrease of ACE2 content was relatively slight between young-adult and middle-aged groups (by 25% in male and 18% in female, respectively). Although there was no gender-related difference of ACE2 in young-adult and middle-aged groups, a significantly higher ACE2 content was detected in old female rats than male. In conclusion, the more elevated ACE2 in young adults as compared to aged groups may contribute to the predominance in SARS attacks in this age group.
has issue date	2006-04-04(xsd:dateTime)
bibo:doi	10.1016/j.lfs.2005.09.038
bibo:pmid	16303146
has license	els-covid
sha1sum (hex)	7684a38d0d7d2c6e65a82b43ec39ffa64fda2297
schema:url	https://doi.org/10.1016/j.lfs.2005.09.038
resource representing a document's title	Age- and gender-related difference of ACE2 expression in rat lung
has PubMed Central identifier	PMC7094566
has PubMed identifier	16303146
schema:publication	Life Sciences
resource representing a document's body	covid:7684a38d0d7d2c6e65a82b43ec39ffa64fda2297#body_text
is schema:about of	named entity 'ACE2' named entity 'groups' named entity 'identified' named entity 'young-adult' named entity 'lung' named entity 'female' named entity 'ACE2' named entity 'middle-aged' named entity 'middle-aged' named entity 'middle-aged' named entity 'ACE2' named entity 'obvious' named entity 'GENDER' named entity 'FEMALE' named entity 'ACE2' named entity 'ATTACKS' named entity 'CHARACTERISTIC' named entity 'OLD' named entity 'SLIGHT' named entity 'EVALUATED' named entity '0.001' named entity 'ANGIOTENSIN-CONVERTING ENZYME 2' named entity 'PATHOGENESIS' named entity 'ENDOTHELIUM' named entity 'EPIDEMIOLOGIC' named entity 'LUNG' named entity 'ITS' covid:arg/7684a38d0d7d2c6e65a82b43ec39ffa64fda2297 named entity 'FUNCTIONAL' named entity 'SMOOTH MUSCLE CELLS' named entity 'DATA' named entity 'GROUPS' named entity 'EFFECT' named entity 'DETECTED' named entity 'EXPRESSION' named entity 'BRONCHIOLAR SMOOTH MUSCLE' named entity 'ELEVATED' named entity 'SARS' named entity 'MIDDLE' named entity 'CONCLUSION' named entity 'AGES' named entity 'CONTRIBUTE ' named entity 'ADULT' named entity 'CONTENT' named entity 'RECEPTOR' named entity 'EXPRESSION' named entity 'DECREASE' named entity 'PRIME' named entity 'SIGNAL' named entity 'AGE' named entity 'RAT LUNG' named entity 'PATIENTS' named entity 'REDUCED' named entity 'BRONCHIOLAR EPITHELIUM' named entity 'RELATED' named entity 'DETERMINE' named entity 'DIFFERENCE' named entity 'GENDERS' named entity 'GENDER' named entity 'TARGET' named entity 'MALE' named entity 'RECENTLY' named entity 'HIGHER' named entity 'SIMILAR' named entity 'ALVEOLAR EPITHELIUM' named entity 'COMPARED' named entity 'SARS VIRUS' named entity 'PULMONARY VESSELS' named entity '24 MONTHS' named entity '12 MONTHS' named entity 'DISTINCT' named entity 'RATS' named entity '3 MONTHS' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'YOUNG ADULTS' named entity 'YOUNG' named entity 'OBVIOUS'

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