About: Pulmonary and systemic involvement of COVID‐19 assessed by ultrasound‐guided minimally invasive autopsy

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About: Pulmonary and systemic involvement of COVID‐19 assessed by ultrasound‐guided minimally invasive autopsy Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Pulmonary and systemic involvement of COVID‐19 assessed by ultrasound‐guided minimally invasive autopsy
Creator	Paulo, São Paula, Ana Pinho, Rebello Renato, João Aparecida De Almeida Monteiro, Renata Dolhnikoff, Marisa Filho, Jair Hilário, Paulo Mauad, Thais Nunes Duarte-Neto, Amaro Pierre De Oliveira, Ellen Saldiva, Nascimento Soares Gomes-Gouvêa, Michele Ferraz Da Silva, Fernando Avancini, Denise Malheiros, Costa Salles, Moreira Souza De Oliveira, Ilka
Source	Medline; PMC
abstract	AIMS: Brazil ranks high in the number of COVID‐19 cases and COVID‐19’s mortality rate. In this context, autopsies are important to confirm the disease, determine associated conditions, and study the pathophysiology of this novel disease. In order to follow biosafety recommendations, we used Ultrasound‐Guided Minimally Invasive Autopsy (MIA‐US) to assess the systemic involvement of COVID‐19 and present the results of ten initial autopsies. METHODS AND RESULTS: We used MIA‐US for tissue sampling of lungs, liver, heart, kidneys, spleen, brain, skin, skeletal muscle and testis for histology and RT‐PCR to detect SARS‐COV‐2‐RNA. All patients presented exudative/proliferative Diffuse Alveolar Damage. There were intense pleomorphic cytopathic effects on the respiratory epithelium, including airway and alveolar cells. Fibrinous thrombi in alveolar arterioles were present in eight patients and all patients presented a high density of alveolar megakaryocytes. Small thrombi were less frequently observed in glomeruli, spleen, heart, dermis, testis, and liver sinusoids. The main systemic findings were associated with comorbidities, age, and sepsis, in addition to possible tissue damage due to the viral infection such as myositis, dermatitis, myocarditis and orchitis. CONCLUSIONS: MIA‐US is safe and effective for the study of severe COVID‐19. Our findings show that COVID‐19 is a systemic disease with major events in the lungs and involvement of various organs and tissues. Pulmonary changes are the result of severe epithelial injury and microthrombotic vascular phenomena. These findings indicate that both epithelial and vascular injury should be addressed in therapeutic approaches.
has issue date	2020-05-22(xsd:dateTime)
bibo:doi	10.1111/his.14160
bibo:pmid	32443177
has license	no-cc
sha1sum (hex)	7724cd6ac6beb1d16aa0a652f034d1800b142e82
schema:url	https://doi.org/10.1111/his.14160
resource representing a document's title	Pulmonary and systemic involvement of COVID‐19 assessed by ultrasound‐guided minimally invasive autopsy
has PubMed Central identifier	PMC7280721
has PubMed identifier	32443177
schema:publication	Histopathology
resource representing a document's body	covid:7724cd6ac6beb1d16aa0a652f034d1800b142e82#body_text
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