About: Characterization of blood mononuclear cells producing IFNα following induction by coronavirus-infected cells (porcine transmissible gastroenteritis virus)

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About: Characterization of blood mononuclear cells producing IFNα following induction by coronavirus-infected cells (porcine transmissible gastroenteritis virus) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Characterization of blood mononuclear cells producing IFNα following induction by coronavirus-infected cells (porcine transmissible gastroenteritis virus)
Creator	Charley, B Lavenant, L
Source	Elsevier; Medline; PMC
abstract	Abstract Porcine blood mononuclear cells (PBMC) were shown to produce interferon-α (IFNα) following incubation with cells infected by a coronavirus, transmissible gastroenteritis virus. Monoclonal antibodies (mAb) with specificities for leukocyte subsets and major histocompatibility complex (MHC) antigens were used to characterize IFNα producer cells. The production of IFNα was found to be a function of non-phagocytic, non-adherent, non-T, non-B, CD4+ (and to a lesser extent CD8+) MHC-class-II-positive cells. Furthermore, addition of anti-MHC (class II) mAb during PBMC incubation with virus-infected cells reduced IFN yields, suggesting that masking of these surface antigens alters PBMC responsiveness to IFN induction.
has issue date	1990-02-28(xsd:dateTime)
bibo:doi	10.1016/0923-2494(90)90133-j
bibo:pmid	2167506
has license	els-covid
sha1sum (hex)	7743c3acb2cb07e744352bd554f7da4cafb54e5f
schema:url	https://doi.org/10.1016/0923-2494%2890%2990133-j
resource representing a document's title	Characterization of blood mononuclear cells producing IFNα following induction by coronavirus-infected cells (porcine transmissible gastroenteritis virus)
has PubMed Central identifier	PMC7135751
has PubMed identifier	2167506
schema:publication	Research in Immunology
resource representing a document's body	covid:7743c3acb2cb07e744352bd554f7da4cafb54e5f#body_text
is schema:about of	named entity 'function' named entity 'Monoclonal antibodies' named entity 'IFN' named entity 'leukocyte' named entity 'antigens' named entity 'IFNa' covid:arg/7743c3acb2cb07e744352bd554f7da4cafb54e5f named entity 'PBMC' named entity 'PBMC' named entity 'mAb' named entity 'IFNa' named entity 'major histocompatibility complex' named entity 'MHC' named entity 'incubation' named entity 'mAb' named entity 'mAb' named entity 'PBMC' named entity 'MHC' named entity 'Monoclonal antibodies' named entity 'Porcine' named entity 'antigens' named entity 'IFN' named entity 'CORONAVIRUS' named entity 'BLOOD' named entity 'PBMC' named entity '37°C' named entity 'supernatants' named entity 'complement' named entity 'pig' named entity '37°C' named entity 'IFNa' named entity 'PBMC' named entity 'complement' named entity 'RPMI' named entity 'NIH' named entity 'cell surface' named entity 'PBMC' named entity 'PBMC' named entity 'peripheral blood mononuclear cells' named entity 'microplates' named entity 'co-incubation' named entity 'IFN' named entity 'co-incubation' named entity 'IFN' named entity 'murine' named entity 'mAb' named entity 'IFN' named entity 'foetal calf serum' named entity 'mAb' named entity 'kidney cells' named entity 'antibody' named entity 'glutaraldehyde' named entity 'IFN' named entity 'dialysed' named entity 'transmembrane' named entity 'IFN' named entity 'porcine' named entity 'mAb' named entity 'lymphocytes' named entity 'phagocytic' named entity 'IFN' named entity 'viral protein' named entity 'mAb' named entity 'complement' named entity 'Bethesda, MD' named entity 'mAb' named entity 'non-adherent' named entity 'trypan blue' named entity 'table II' named entity 'PBMC' named entity 'PBMC' named entity 'complement' named entity 'porcine' named entity 'cytomegalovirus' named entity 'mycoplasma' named entity 'leukocyte' named entity 'Newcastle disease virus' named entity 'hybridization' named entity 'IFN' named entity 'Lymphocyte'

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