About: Graves disease-induced thrombotic thrombocytopenic purpura: a case report

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Graves disease-induced thrombotic thrombocytopenic purpura: a case report
Creator	Hossain, Mohammad Khan, Ijaz Gupta, Varsha Asif, Arif Chaughtai, Saira Chaughtai, Zeeshan Ong, Raquel
Source	PMC
abstract	BACKGROUND: Thrombotic thrombocytopenic purpura is an autoimmune disease that carries a high mortality. Very few case reports in the literature have described a relationship between Graves disease and thrombotic thrombocytopenic purpura. We present a case of a patient with Graves disease who was found to be biochemically and clinically hyperthyroid with concurrent thrombotic thrombocytopenic purpura. CASE PRESENTATION: Our patient was a 30-year-old African American woman with a history of hypertension and a family history of Graves disease who had recently been diagnosed with hyperthyroidism and placed on methimazole. She presented to our hospital with the complaints of progressive shortness of breath and dizziness. Her vital signs were stable. On further evaluation, she was diagnosed with thrombotic thrombocytopenic purpura, depending on clinical and laboratory results, and also was found to have highly elevated free T4 and suppressed thyroid-stimulating hormone. She received multiple sessions of plasmapheresis and ultimately had a total thyroidectomy. The patient’s hospital course was complicated by pneumonia and acute respiratory distress syndrome. Her platelets stabilized at approximately 50,000/μl, and her ADAMTS13 activity normalized despite multiple complications. The patient ultimately had a cardiac arrest with pulseless electrical activity and died despite multiple attempts at cardiopulmonary resuscitation. CONCLUSION: Graves disease is an uncommon trigger for the development of thrombotic thrombocytopenic purpura, and very few cases have been reported thus far. Therefore, clinicians should be aware of this association in the appropriate clinical context to comprehensively monitor hyperthyroid patients during treatment.
has issue date	2019-12-13(xsd:dateTime)
bibo:doi	10.1186/s13256-019-2307-1
bibo:pmid	31831041
has license	cc-by
sha1sum (hex)	775c8ddaf3694b2de176210dffc9772208f3aacd
schema:url	https://doi.org/10.1186/s13256-019-2307-1
resource representing a document's title	Graves disease-induced thrombotic thrombocytopenic purpura: a case report
has PubMed Central identifier	PMC6909611
has PubMed identifier	31831041
schema:publication	J Med Case Rep
resource representing a document's body	covid:775c8ddaf3694b2de176210dffc9772208f3aacd#body_text
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