About: Long-term human coronavirus-myelin cross-reactive T-cell clones derived from multiple sclerosis patients

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About: Long-term human coronavirus-myelin cross-reactive T-cell clones derived from multiple sclerosis patients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Long-term human coronavirus-myelin cross-reactive T-cell clones derived from multiple sclerosis patients
Creator	Desforges, Marc Talbot, Pierre Boucher, Annie Duquette, Pierre
Source	Elsevier; Medline; PMC
abstract	Autoimmune reactions associated with MS involve genetic and environmental factors. Because murine coronaviruses induce an MS-like disease, the human coronaviruses (HCoV) are attractive candidates as environmental factors involved in a demyelinating pathology. We previously reported the isolation of HCoV-229E/myelin basic protein (MBP) cross-reactive T-cell lines (TCL) in MS patients. To investigate antigenic cross-reactivity at the molecular level, 155 long-term T-cell clones (TCC) were derived from 32 MS patients by in vitro selection with MBP, proteolipid protein (PLP) or HCoV (strains 229E and OC43). Overall, 114 TCC were virus-specific, 31 were specific for myelin Ag and 10 other were HCoV/myelin cross-reactive. Twenty-eight virus-specific TCC and 7 myelin-specific TCC were obtained from six healthy donors. RACE RT-PCR amplification of the Vβ chains of five of ten the cross-reactive TCC confirmed clonality and sequencing identified the CDR3 region associated with cross-reactivity. Our findings have promising implications in the investigation of the role of molecular mimicry between coronaviruses and myelin in MS as a mechanism related to disease initiation or relapses.
has issue date	2007-04-19(xsd:dateTime)
bibo:doi	10.1016/j.clim.2007.02.002
bibo:pmid	17448727
has license	no-cc
sha1sum (hex)	776f4161246a48f34b4acbbd62f18d9b39508011
schema:url	https://doi.org/10.1016/j.clim.2007.02.002
resource representing a document's title	Long-term human coronavirus-myelin cross-reactive T-cell clones derived from multiple sclerosis patients
has PubMed Central identifier	PMC7106099
has PubMed identifier	17448727
schema:publication	Clin Immunol
resource representing a document's body	covid:776f4161246a48f34b4acbbd62f18d9b39508011#body_text
is schema:about of	named entity 'patients' named entity 'TCL' named entity 'chains' named entity 'patients' named entity 'T-cell' named entity 'multiple sclerosis' named entity 'OBTAINED' named entity 'LONG-TERM' named entity 'REGION' named entity 'FINDINGS' named entity 'RELAPSES' named entity 'RACE' named entity 'C O' named entity 'HEALTHY' named entity 'RT-PCR' named entity 'MOLECULAR MIMICRY' named entity 'VIRUS' named entity 'OC43' named entity 'IDENTIFIED' named entity '267' named entity 'ENVIRONMENTAL FACTORS' named entity 'LINES' named entity 'BASIC PROTEIN' named entity 'OVERALL' named entity 'AVA' named entity 'INVESTIGATION' named entity 'CHAINS' named entity 'CLONALITY' named entity 'CROSS' named entity 'ROLE' named entity 'DISEASE' named entity 'TWENTY-EIGHT' named entity 'INDUCE' named entity 'PATIENTS' named entity 'DERIVED' named entity 'DONORS' named entity 'REACTIVITY' named entity 'CLINICAL IMMUNOLOGY' named entity 'INITIATION' named entity 'CROSS-REACTIVE' named entity 'MBP' named entity 'A T' named entity 'MURINE' named entity 'DERIVED' named entity 'PROTEOLIPID' named entity '258' named entity 'OUR' named entity 'MYELIN' named entity 'LIKE' named entity 'I E' named entity 'LONG-TERM' named entity 'CROSS-REACTIVE' named entity 'HAVE' named entity '229E' named entity 'TCC' named entity 'TO INVESTIGATE' named entity 'CELL CLONES' named entity 'SPECIFIC' named entity 'MYELIN' named entity 'CELL CLONES' named entity 'ATTRACTIVE' named entity 'MECHANISM' named entity '114' named entity 'GENETIC' named entity 'T-CELL' named entity 'PCR AMPLIFICATION' named entity 'SEQUENCING' named entity 'RELATED' named entity 'REPORTED' named entity 'D I' named entity 'CDR3' named entity 'PATHOLOGY' named entity 'AUTOIMMUNE REACTIONS' named entity 'T-CELL' named entity 'HUMAN CORONAVIRUS' named entity 'MULTIPLE SCLEROSIS' named entity 'MOLECULAR' named entity 'ISOLATION'

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