About: CXCR2 is critical for dsRNA-induced lung injury: relevance to viral lung infection

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: CXCR2 is critical for dsRNA-induced lung injury: relevance to viral lung infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	CXCR2 is critical for dsRNA-induced lung injury: relevance to viral lung infection
Creator	Xue, Ying Strieter, Robert Belperio, John Burdick, Marie Keane, Michael Londhe, Vedang
Source	Medline; PMC
abstract	BACKGROUND: Respiratory viral infections are characterized by the infiltration of leukocytes, including activated neutrophils into the lung that can lead to sustained lung injury and potentially contribute to chronic lung disease. Specific mechanisms recruiting neutrophils to the lung during virus-induced lung inflammation and injury have not been fully elucidated. Since CXCL1 and CXCL2/3, acting through CXCR2, are potent neutrophil chemoattractants, we investigated their role in dsRNA-induced lung injury, where dsRNA (Poly IC) is a well-described synthetic agent mimicking acute viral infection. METHODS: We used 6–8 week old female BALB/c mice to intratracheally inject either single-stranded (ssRNA) or double-stranded RNA (dsRNA) into the airways. The lungs were then harvested at designated timepoints to characterize the elicited chemokine response and resultant lung injury following dsRNA exposure as demonstrated qualititatively by histopathologic analysis, and quantitatively by FACS, protein, and mRNA analysis of BAL fluid and tissue samples. We then repeated the experiments by first pretreating mice with an anti-PMN or corresponding control antibody, and then subsequently pretreating a separate cohort of mice with an anti-CXCR2 or corresponding control antibody prior to dsRNA exposure. RESULTS: Intratracheal dsRNA led to significant increases in neutrophil infiltration and lung injury in BALB/c mice at 72 h following dsRNA, but not in response to ssRNA (Poly C; control) treatment. Expression of CXCR2 ligands and CXCR2 paralleled neutrophil recruitment to the lung. Neutrophil depletion studies significantly reduced neutrophil infiltration and lung injury in response to dsRNA when mice were pretreated with an anti-PMN monoclonal Ab. Furthermore, inhibition of CXCR2 ligands/CXCR2 interaction by pretreating dsRNA-exposed mice with an anti-CXCR2 neutralizing Ab also significantly attenuated neutrophil sequestration and lung injury. CONCLUSION: These findings demonstrate that CXC chemokine ligand/CXCR2 biological axis is critical during the pathogenesis of dsRNA-induced lung injury relevant to acute viral infections.
has issue date	2005-05-28(xsd:dateTime)
bibo:doi	10.1186/1476-9255-2-4
bibo:pmid	15921526
has license	cc-by
sha1sum (hex)	77aae7c898acfb4ff723de2af7928a38b169878a
schema:url	https://doi.org/10.1186/1476-9255-2-4
resource representing a document's title	CXCR2 is critical for dsRNA-induced lung injury: relevance to viral lung infection
has PubMed Central identifier	PMC1156932
has PubMed identifier	15921526
schema:publication	J Inflamm (Lond)
resource representing a document's body	covid:77aae7c898acfb4ff723de2af7928a38b169878a#body_text
is schema:about of	named entity 'RELEVANCE' named entity 'VIRAL' named entity 'viral infections' named entity 'CXCR2' named entity 'LEAD' named entity 'NEUTROPHIL' named entity 'LUNG' named entity 'LUNG INJURY' named entity 'CRITICAL' named entity 'DESCRIBED' named entity 'MECHANISMS' covid:arg/77aae7c898acfb4ff723de2af7928a38b169878a named entity 'BACKGROUND' named entity 'LEUKOCYTES' named entity 'ROLE' named entity 'CHARACTERIZED' named entity 'INFLAMMATION' named entity 'LUNG INFECTION' named entity 'INDUCED' named entity 'INJURY' named entity 'CXCL2' named entity 'JOURNAL ' named entity 'VIRAL INFECTION' named entity 'ACTIVATED' named entity 'FULLY' named entity 'CHRONIC LUNG DISEASE' named entity 'VIRUS' named entity 'LUNG INJURY' named entity 'IS A' named entity 'INDUCED' named entity 'WHERE' named entity 'LUNG INFLAMMATION' named entity 'DSRNA' named entity 'INCLUDING' named entity 'SPECIFIC' named entity 'INFILTRATION' named entity 'SUSTAINED' named entity 'AGENT' named entity 'RECRUITING' named entity 'INVESTIGATED' named entity 'CXCL1' named entity 'CXCR2' named entity 'CONTRIBUTE ' named entity 'HAVE' named entity 'RESPIRATORY' named entity 'VIRAL INFECTIONS' named entity 'ACUTE' named entity 'NEUTROPHILS' named entity 'THEIR' named entity 'DSRNA' named entity 'SYNTHETIC' named entity 'Respiratory' named entity 'neutrophil' named entity 'dsRNA' named entity 'dsRNA' named entity 'CC chemokine' named entity 'endogenous' named entity 'antibody' named entity 'SARS' named entity 'Sigma-Aldrich' named entity 'antigen' named entity 'Winooski' named entity 'chemokines' named entity 'ligand' named entity 'potent' named entity 'CXCR2' named entity 'virus' named entity 'CXCL2' named entity 'lung' named entity 'Respiratory viral infections' named entity 'neutrophils' named entity 'dsRNA' named entity 'Inflammation' named entity 'histopathologic' named entity 'Evans blue' named entity 'CXCR2'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software