About: Monoclonal Antibody to the Receptor for Murine Coronavirus MHV-A59 Inhibits Viral Replication In Vivo

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Monoclonal Antibody to the Receptor for Murine Coronavirus MHV-A59 Inhibits Viral Replication In Vivo
Creator	Holmes, Kathryn Smith, Abigail Cardellichio, Christine Winograd, Deborah Barthold, Stephen De Souza, Mark
Source	Medline; PMC
abstract	Because many strains of mouse hepatitis virus (MHV) infect laboratory mice, no effective vaccine has yet been developed. An alternative approach to control MHV disease is the use of a host cell receptor-targeted ligand. Toaddress the potential usefulness of this approach, a monoclonal antibody directed against the host cell receptor for the coronavirus MHV-A59 was administered to infant mice that were then challenged oronasally with 10(4) intracerebral infant mouse median lethal doses of MHV-A59. Antibody treatment of virus-challenged mice resulted in lower proportions of mice with MHV-A59 in target organs and markedly reduced viral titers in these organs compared with mock-treated infected mice. Some antibody-treated infected mice survived for 7 days after viral challenge, whereas no mock-treated, infected mice survived beyond day 3 after viral inoculation. These results support a receptor-targeted approach to intervention in coronavirus disease.
has issue date	1991-04-01(xsd:dateTime)
bibo:doi	10.1093/infdis/163.4.879
bibo:pmid	1849166
has license	no-cc
sha1sum (hex)	77ba146a186708d66b9743b410d04cd14b003dbf
schema:url	https://doi.org/10.1093/infdis/163.4.879
resource representing a document's title	Monoclonal Antibody to the Receptor for Murine Coronavirus MHV-A59 Inhibits Viral Replication In Vivo
has PubMed Central identifier	PMC7110016
has PubMed identifier	1849166
schema:publication	J Infect Dis
resource representing a document's body	covid:77ba146a186708d66b9743b410d04cd14b003dbf#body_text
is schema:about of	named entity 'cell' named entity 'monoclonal antibody' named entity 'organs' named entity 'address' named entity 'INTERVENTION' named entity 'BEYOND' named entity 'A59' named entity 'MONOCLONAL ANTIBODY' named entity 'APPROACH' named entity 'CHALLENGE' named entity 'USEFULNESS' named entity 'LABORATORY' named entity 'REDUCED' named entity 'DOSES' named entity 'ADMINISTERED' named entity 'SUPPORT' named entity 'INFECT' named entity 'RECEPTOR' named entity 'ORGANS' named entity 'VIRAL' named entity 'VACCINE' named entity 'MOUSE' named entity 'A59' named entity 'INFANT' named entity 'MOCK' named entity 'DIRECTED' named entity 'ADDRESS' named entity 'RESULTS' named entity 'ALTERNATIVE' named entity 'INTRACEREBRAL' named entity 'DAY 3' named entity 'MURINE CORONAVIRUS' named entity 'VIRAL REPLICATION' named entity 'IN VIVO' named entity 'RECEPTOR' named entity 'VIRUS' named entity 'LOWER' named entity 'TARGET' named entity 'EFFECTIVE' named entity 'HOST CELL' named entity 'INOCULATION' named entity 'MARKEDLY' named entity 'DISEASE' named entity 'USE OF' named entity 'MONOCLONAL ANTIBODY' named entity 'MHV' named entity 'MICE' named entity 'CORONAVIRUS' named entity 'INFECTED' named entity 'COMPARED' named entity 'TO CONTROL' named entity 'TREATED' named entity 'TARGETED' named entity 'DAYS' named entity 'MOUSE HEPATITIS VIRUS' named entity 'LIGAND' named entity 'THESE' named entity 'ANTIBODY TREATMENT' named entity 'ANTIBODY' named entity 'STRAINS' named entity 'MEDIAN' named entity 'LETHAL' named entity 'POTENTIAL' covid:arg/77ba146a186708d66b9743b410d04cd14b003dbf named entity 'mice' named entity 'alternative' named entity 'viral' named entity 'viral' named entity 'virus' named entity 'MHV' named entity 'mice' named entity 'These' named entity 'survived' named entity 'Receptor' named entity 'monoclonal antibody' named entity 'receptor'

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