About: Clinical features and short-term outcomes of 221 patients with COVID-19 in Wuhan, China

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical features and short-term outcomes of 221 patients with COVID-19 in Wuhan, China
Creator	Li, Jianguo Hu, Chang Peng, Zhiyong Chen, Yongfeng Pan, Huaqin Zhang, Guqin Luo, Linjie
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: In late December 2019, an outbreak of acute respiratory illness, coronavirus disease 2019 (COVID-19), emerged in Wuhan, China. We aimed to study the epidemiology, clinical features and short-term outcomes of patients with COVID-19 in Wuhan, China. METHODS: We performed a single center, retrospective case series study in 221 patients with laboratory confirmed SARS-CoV-2 pneumonia at a university hospital, including 55 severe patients and 166 non-severe patients, from January 2, 2020 to February 10, 2020. RESULTS: Of the 221 patients with COVID-19, the median age was 55.0 years and 48.9% were male and only 8 (3.6%) patients had a history of exposure to the Huanan Seafood Market. Compared to the non-severe pneumonia patients, the median age of the severe patients was significantly older, and they were more likely to have chronic comorbidities. Most common symptoms in severe patients were high fever, anorexia and dyspnea. On admission, 33.0% patients showed leukopenia and 73.8% showed lymphopenia. In addition, the severe patients suffered a higher rate of co-infections with bacteria or fungus and they were more likely to developing complications. As of February 15, 2020, 19.0% patients had been discharged and 5.4% patients died. 80% of severe cases received ICU (intensive care unit) care, and 52.3% of them transferred to the general wards due to relieved symptoms, and the mortality rate of severe patients in ICU was 20.5%. CONCLUSIONS: Patients with elder age, chronic comorbidities, blood leukocyte/lymphocyte count, procalcitonin level, co-infection and severe complications might increase the risk of poor clinical outcomes.
has issue date	2020-04-09(xsd:dateTime)
bibo:doi	10.1016/j.jcv.2020.104364
bibo:pmid	32311650
has license	no-cc
sha1sum (hex)	77becc0c569bd4f29bc5d27a20fa62cd106373c6
schema:url	https://doi.org/10.1016/j.jcv.2020.104364
resource representing a document's title	Clinical features and short-term outcomes of 221 patients with COVID-19 in Wuhan, China
has PubMed Central identifier	PMC7194884
has PubMed identifier	32311650
schema:publication	J Clin Virol
resource representing a document's body	covid:77becc0c569bd4f29bc5d27a20fa62cd106373c6#body_text
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