About: Traditional Chinese Medicine as a Potential Source for HSV-1 Therapy by Acting on Virus or the Susceptibility of Host

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About: Traditional Chinese Medicine as a Potential Source for HSV-1 Therapy by Acting on Virus or the Susceptibility of Host Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Traditional Chinese Medicine as a Potential Source for HSV-1 Therapy by Acting on Virus or the Susceptibility of Host
Creator	He, Rong-Rong Kurihara, Hiroshi Li, Yi-Fang Luo, Zhuo Yan, Chang Li, Wen Chen, Guo-Dong Duan, Wen-Jun Gao, Hao Liu, Li-Fang Wang, Xiao-Hua Yan, Chang-Yu
source	Medline; PMC
abstract	Herpes simplex virus type 1 (HSV-1) is the most common virus, with an estimated infection rate of 60–95% among the adult population. Once infected, HSV-1 can remain latent in the host for a lifetime and be reactivated in patients with a compromised immune system. Reactivation of latent HSV-1 can also be achieved by other stimuli. Though acyclovir (ACV) is a classic drug for HSV-1 infection, ACV-resistant strains have been found in immune-compromised patients and drug toxicity has also been commonly reported. Therefore, there is an urge to search for new anti-HSV-1 agents. Natural products with potential anti-HSV-1 activity have the advantages of minimal side effects, reduced toxicity, and they exert their effect by various mechanisms. This paper will not only provide a reference for the safe dose of these agents if they are to be used in humans, referring to the interrelated data obtained from in vitro experiments, but also introduce the main pharmacodynamic mechanisms of traditional Chinese medicine (TCM) against HSV-1. Taken together, TCM functions as a potential source for HSV-1 therapy by direct (blocking viral attachment/absorption/penetration/replication) or indirect (reducing the susceptibility to HSV-1 or regulating autophagy) antiviral activities. The potential of these active components in the development of anti-HSV-1 drugs will also be described.
has issue date	2018-10-20(xsd:dateTime)
bibo:doi	10.3390/ijms19103266
bibo:pmid	30347851
has license	cc-by
sha1sum (hex)	77dc3c4e78b6fe5c233613de24779897f673bb9c
schema:url	https://doi.org/10.3390/ijms19103266
resource representing a document's title	Traditional Chinese Medicine as a Potential Source for HSV-1 Therapy by Acting on Virus or the Susceptibility of Host
has PubMed Central identifier	PMC6213986
has PubMed identifier	30347851
schema:publication	Int J Mol Sci
resource representing a document's body	covid:77dc3c4e78b6fe5c233613de24779897f673bb9c#body_text
is schema:about of	named entity 'dose' named entity 'HSV-1' named entity 'mechanisms' named entity 'minimal' named entity 'data' named entity 'activities' named entity 'drug' named entity 'Natural products' named entity 'estimated' named entity 'reference' named entity 'introduce' named entity 'Potential' named entity 'type 1' named entity 'reduced' named entity 'advantages' named entity 'lifetime' named entity 'indirect' named entity 'commonly' named entity 'Once' named entity 'drug toxicity' named entity 'antiviral' named entity 'provide' named entity 'HSV-1' named entity 'drug toxicity' named entity 'TCM' named entity 'HSV-1' named entity 'HSV-1' named entity 'acyclovir' named entity 'toxicity' named entity 'HSV-1' named entity 'Traditional Chinese Medicine' named entity 'Virus' named entity 'urge' named entity 'herpes labialis' named entity 'hyperphosphorylation' named entity 'ICP34.5' named entity 'genome' named entity 'weakened immunity' named entity 'virus' named entity 'natural products' named entity 'protein' named entity 'enzyme' named entity 'alkaloids' named entity 'MAVS' named entity 'infection' named entity 'life cycle' named entity 'HSV-1' named entity 'pure compounds' named entity 'chemical class' named entity 'HSV-1' named entity 'autophagy' named entity 'HSV-1' named entity 'Antrodia' named entity 'phosphorylation' named entity 'HPLC' named entity 'nucleoside analogues' named entity 'encephalitis' named entity 'Isoquinoline' named entity 'mTOR' named entity 'OPTN' named entity 'DNA polymerase' named entity 'transcription' named entity 'IRF3' named entity 'TCM' named entity 'thin-layer chromatography' named entity 'HSV' named entity 'ribosomal' named entity 'hepatitis' named entity 'Lamiaceae' named entity 'oxidative stress'

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