About: Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury

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About: Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury
Creator	Wang, Wei Jiang, Chengyu Duan, Yueqiang Gu, Hongjing Lai, Chengcai Wang, Xiliang Yang, Penghui Yang, Xiaolan Zhang, Shaogeng Zhao, Zhongpeng Zhang, Liangyan Cai, Maosheng Chen, Weiwen Zhen, Wenbo Penninger, Josef
Source	Medline; PMC
abstract	Since March 2013, the emergence of an avian-origin influenza A (H7N9) virus has raised concern in China. Although most infections resulted in respiratory illness, some severe cases resulted in acute respiratory distress syndrome (ARDS), which is a severe form of acute lung injury (ALI) that further contributes to morbidity. To date, no effective drugs that improve the clinical outcome of influenza A (H7N9) virus-infected patients have been identified. Angiotensin-converting enzyme (ACE) and ACE2 are involved in several pathologies such as cardiovascular functions, renal disease, and acute lung injury. In the current study, we report that ACE2 could mediate the severe acute lung injury induced by influenza A (H7N9) virus infection in an experimental mouse model. Moreover, ACE2 deficiency worsened the disease pathogenesis markedly, mainly by targeting the angiotensin II type 1 receptor (AT1). The current findings demonstrate that ACE2 plays a critical role in influenza A (H7N9) virus-induced acute lung injury, and suggest that might be a useful potential therapeutic target for future influenza A (H7N9) outbreaks.
has issue date	2014-11-13(xsd:dateTime)
bibo:doi	10.1038/srep07027
bibo:pmid	25391767
has license	cc-by
sha1sum (hex)	77f34000cd69ab822903562a0004012eeebe7605
schema:url	https://doi.org/10.1038/srep07027
resource representing a document's title	Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury
has PubMed Central identifier	PMC4229671
has PubMed identifier	25391767
schema:publication	Sci Rep
resource representing a document's body	covid:77f34000cd69ab822903562a0004012eeebe7605#body_text
is schema:about of	named entity 'VIRUS' named entity 'MEDIATES' named entity 'Angiotensin-converting enzyme 2' named entity 'ANGIOTENSIN-CONVERTING ENZYME 2' named entity 'ACUTE LUNG INJURY' named entity 'INDUCED' named entity 'INFLUENZA' named entity 'H7N9' named entity 'acute lung injury' named entity 'ACE2' named entity 'virus' named entity 'virus' named entity 'critical role' named entity 'ACE2' named entity 'ACE2' named entity 'influenza' named entity 'H7N9' named entity 'Beijing' named entity 'research groups' named entity 'influenza virus' named entity 'PCR' named entity 'H7N9' named entity 'viral titers' named entity 'H7N9' named entity 'influenza' named entity 'H7N9' named entity 'infection' named entity 'H7N9' named entity 'virus' named entity 'mouse model' named entity 'virus infection' named entity 'lungs' named entity 'histopathology' named entity 'anesthetized' named entity 'titration' named entity 'influenza' named entity 'infection' named entity 'H7N9' named entity 'leukocyte' named entity 'H7N9' named entity 'influenza' named entity 'molecular basis' named entity 'lung tissue' named entity 'infection' named entity 'host response' named entity 'ACE2' named entity 'influenza' named entity 'Applied Biosystems' named entity 'virus' named entity 'plasma' named entity 'AT1 receptor' named entity 'ACE2' named entity 'lung edema' named entity 'losartan' named entity 'influenza' named entity 'KO mice' named entity 'lungs' named entity 'Institutional Animal Care and Use Committee' named entity 'mRNA' named entity 'H7N9' named entity 'H7N9' named entity 'ACE2' named entity 'KO mice' named entity 'virus' named entity 'Biosafety Level 3' named entity 'H7N9' named entity 'AT1 receptor'

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