About: Targeting Inflammatory Demyelinating Lesions to Sites of Wallerian Degeneration

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About: Targeting Inflammatory Demyelinating Lesions to Sites of Wallerian Degeneration Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Targeting Inflammatory Demyelinating Lesions to Sites of Wallerian Degeneration
Creator	Tsunoda, Ikuo Fujinami, Robert Fujinami, S Saijoh, Yukio Tanaka, Tomoko
Source	Elsevier; Medline; PMC
abstract	In Theiler’s murine encephalomyelitis virus (TMEV) infection, an animal model for multiple sclerosis (MS), axonal injury precedes inflammatory demyelinating lesions, and the distribution of axonal damage present during the early phase of infection corresponds to regions where subsequent demyelination occurs during the chronic phase. We hypothesized that axonal damage recruits inflammatory cells to sites of Wallerian degeneration, leading to demyelination. Three weeks after TMEV infection, axonal degeneration was induced in the posterior funiculus of mice by injecting the toxic lectin Ricinus communis agglutinin (RCA) I into the sciatic nerve. Neuropathology was examined 1 week after lectin injection. Control mice, infected with TMEV but receiving no RCA I, had inflammatory demyelinating lesions in the anterior/lateral funiculi. Other control mice that received RCA I alone did not develop inflammatory lesions. In contrast, RCA I injection into TMEV-infected mice induced lesions in the posterior funiculus in addition to the anterior/lateral funiculi. We found no differences in lymphoproliferative responses or antibody titers against TMEV among the groups. This suggests that axonal degeneration contributes to the recruitment of inflammatory cells into the central nervous system by altering the local microenvironment. In this scenario, lesions develop from the axon (inside) to the myelin (outside) (Inside-Out model).
has issue date	2007-11-01(xsd:dateTime)
bibo:doi	10.2353/ajpath.2007.070147
bibo:pmid	17823280
has license	green-oa
sha1sum (hex)	780226950b15c78ff3c51f89d2a057558ef79482
schema:url	https://doi.org/10.2353/ajpath.2007.070147
resource representing a document's title	Targeting Inflammatory Demyelinating Lesions to Sites of Wallerian Degeneration
has PubMed Central identifier	PMC2043517
has PubMed identifier	17823280
schema:publication	The American Journal of Pathology
resource representing a document's body	covid:780226950b15c78ff3c51f89d2a057558ef79482#body_text
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