About: Marburg virus regulates the IRE1/XBP1-dependent unfolded protein response to ensure efficient viral replication

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About: Marburg virus regulates the IRE1/XBP1-dependent unfolded protein response to ensure efficient viral replication Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Marburg virus regulates the IRE1/XBP1-dependent unfolded protein response to ensure efficient viral replication
Creator	Becker, Stephan Krähling, Verena Rohde, Cornelius
Source	Medline; PMC
abstract	Viruses regulate cellular signalling pathways to ensure optimal viral replication. During Marburg virus (MARV) infection, large quantities of the viral glycoprotein GP are produced in the ER; this may result in the activation of the unfolded protein response (UPR). The most conserved pathway to trigger UPR is initiated by IRE1. Activation of IRE1 results in auto-phosphorylation, splicing of the XBP1 mRNA and translation of the XBP1s protein. XBP1s binds cis-acting UPR elements (UPRE) which leads to the enhanced expression of genes which should restore ER homeostasis. XBP1u protein is translated, if IRE1 is not activated. Here we show that ectopic expression of MARV GP activated the IRE1-XBP1 axis of UPR as monitored by UPRE luciferase assays. However, while at 24 h of infection with MARV IRE1 was phosphorylated, expression of XBP1s was only slightly enhanced and UPRE activity was not detected. The IRE1-XBP1 axis was not active at 48 h p.i. Co-expression studies of MARV proteins demonstrated that the MARV protein VP30 suppressed UPRE activation. Co-immunoprecipitation analyses revealed an RNA-dependent interaction of VP30 with XBP1u. Knock-out of IRE1 supported MARV infection at late time points. Taken together, these results suggest that efficient MARV propagation requires specific regulation of IRE1 activity.
has issue date	2019-09-07(xsd:dateTime)
bibo:doi	10.1080/22221751.2019.1659552
bibo:pmid	31495285
has license	cc-by
sha1sum (hex)	78138c22f695836b6da58f74c78a8066204a2b12
schema:url	https://doi.org/10.1080/22221751.2019.1659552
resource representing a document's title	Marburg virus regulates the IRE1/XBP1-dependent unfolded protein response to ensure efficient viral replication
has PubMed Central identifier	PMC6746283
has PubMed identifier	31495285
schema:publication	Emerg Microbes Infect
resource representing a document's body	covid:78138c22f695836b6da58f74c78a8066204a2b12#body_text
is schema:about of	named entity 'UPR' named entity 'Co-immunoprecipitation' named entity 'protein' named entity 'binds' named entity 'ensure' named entity 'RESPONSE TO' named entity 'LEADS' named entity 'SPLICING' named entity 'SUPPRESSED' named entity 'RNA' named entity 'HOMEOSTASIS' named entity 'GENES' named entity 'PROTEIN ' named entity 'REGULATION' named entity 'OPTIMAL' named entity 'SUPPORTED' named entity 'TIME' named entity 'AUTO' named entity 'REGULATE' named entity 'XBP1' named entity 'ECTOPIC EXPRESSION' named entity 'HERE' named entity 'SPECIFIC' named entity 'KNOCK-OUT' named entity 'PATHWAYS' named entity 'VIRUSES' named entity 'ELEMENTS' named entity 'TRANSLATED' named entity 'MONITORED' named entity 'PROTEINS' named entity 'VIRAL REPLICATION' named entity 'CO-IMMUNOPRECIPITATION' named entity 'PHOSPHORYLATION' named entity 'PROPAGATION' named entity 'TRIGGER' named entity 'LARGE' named entity 'PHOSPHORYLATED' named entity 'LATE' named entity 'NOT DETECTED' named entity 'PATHWAY' named entity 'MARBURG VIRUS ' named entity 'EFFICIENT' named entity 'ENHANCED' named entity 'TAKEN' named entity 'THESE' named entity 'MARBURG VIRUS ' named entity 'STUDIES' named entity 'CONSERVED' named entity 'CELLULAR' named entity 'VIRAL GLYCOPROTEIN' named entity 'MRNA' named entity 'DEPENDENT' named entity 'IRE1' named entity 'EFFICIENT' named entity 'UNFOLDED PROTEIN RESPONSE' named entity 'ENSURE' named entity 'INFECTION' named entity 'UNFOLDED PROTEIN RESPONSE' named entity 'QUANTITIES' named entity 'SIGNALLING' named entity 'CIS' named entity 'RESULT' named entity 'ACTIVE' named entity 'RESULTS' named entity 'ACTIVATED' named entity 'ENSURE' named entity 'POINTS' named entity 'INTERACTION' named entity 'SUGGEST' named entity 'BINDS' named entity 'TRANSLATION' named entity 'DEMONSTRATED' named entity 'ACTIVATION' named entity 'ACTIVITY' named entity 'REVEALED' named entity 'IRE1' named entity 'DEPENDENT' named entity 'VIRAL REPLICATION' named entity 'EXPRESSION'

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