About: Bat lung epithelial cells show greater host species-specific innate resistance than MDCK cells to human and avian influenza viruses

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About: Bat lung epithelial cells show greater host species-specific innate resistance than MDCK cells to human and avian influenza viruses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Bat lung epithelial cells show greater host species-specific innate resistance than MDCK cells to human and avian influenza viruses
Creator	Eckerle, Isabella Chang, Kin-Chow Slater, Tessa
Source	Medline; PMC
abstract	BACKGROUND: With the recent discovery of novel H17N10 and H18N11 influenza viral RNA in bats and report on high frequency of avian H9 seroconversion in a species of free ranging bats, an important issue to address is the extent bats are susceptible to conventional avian and human influenza A viruses. METHOD: To this end, three bat species (Eidolon helvum, Carollia perspicillata and Tadarida brasiliensis) of lung epithelial cells were separately infected with two avian and two human influenza viruses to determine their relative host innate immune resistance to infection. RESULTS: All three species of bat cells were more resistant than positive control Madin-Darby canine kidney (MDCK) cells to all four influenza viruses. TB1-Lu cells lacked sialic acid α2,6-Gal receptors and were most resistant among the three bat species. Interestingly, avian viruses were relatively more replication permissive in all three bat species of cells than with the use of human viruses which suggest that bats could potentially play a role in the ecology of avian influenza viruses. Chemical inhibition of the JAK-STAT pathway in bat cells had no effect on virus production suggesting that type I interferon signalling is not a major factor in resisting influenza virus infection. CONCLUSION: Although all three species of bat cells are relatively more resistant to influenza virus infection than control MDCK cells, they are more permissive to avian than human viruses which suggest that bats could have a contributory role in the ecology of avian influenza viruses.
has issue date	2018-04-10(xsd:dateTime)
bibo:doi	10.1186/s12985-018-0979-6
bibo:pmid	29636078
has license	cc-by
sha1sum (hex)	78233b5cc660bff6f716fa6cbb967775bf5c7417
schema:url	https://doi.org/10.1186/s12985-018-0979-6
resource representing a document's title	Bat lung epithelial cells show greater host species-specific innate resistance than MDCK cells to human and avian influenza viruses
has PubMed Central identifier	PMC5894234
has PubMed identifier	29636078
schema:publication	Virol J
resource representing a document's body	covid:78233b5cc660bff6f716fa6cbb967775bf5c7417#body_text
is schema:about of	named entity 'avian' named entity 'host' named entity 'HUMAN INFLUENZA' named entity 'IMPORTANT' named entity 'CONVENTIONAL' named entity 'OF FREE' named entity 'BATS' named entity 'SUSCEPTIBLE' named entity 'NOVEL' named entity 'AVIAN' named entity 'RECENT' named entity 'EXTENT' named entity 'SEROCONVERSION' named entity 'ADDRESS' named entity 'INFLUENZA' named entity 'MDCK CELLS' named entity 'INFLUENZA VIRUSES' named entity 'RESISTANCE' named entity 'AVIAN INFLUENZA' named entity 'VIRUSES' named entity 'SPECIFIC' named entity 'EPITHELIAL CELLS' named entity 'GREATER' named entity 'VIRAL RNA' named entity 'DISCOVERY' named entity 'BACKGROUND' named entity 'ISSUE' named entity 'HIGH FREQUENCY' named entity 'REPORT' named entity 'INFLUENZA A' named entity 'BAT LUNG' named entity 'HUMAN' named entity 'HOST SPECIES' named entity 'SPECIES' covid:arg/78233b5cc660bff6f716fa6cbb967775bf5c7417 named entity 'extent' named entity 'seroconversion' named entity 'bats' named entity 'viruses' named entity 'avian influenza viruses' named entity 'MDCK' named entity 'influenza virus' named entity 'Qiagen' named entity 'gene' named entity 'cell surface' named entity 'cytoplasmic' named entity 'lectins' named entity 'influenza viruses' named entity 'neuraminidase' named entity 'Positively stained' named entity 'infection' named entity '37°C' named entity 'USSR' named entity 'lung' named entity 'pyridone' named entity 'bat' named entity 'hpi' named entity 'epithelial cells' named entity 'vRNP' named entity 'antiviral' named entity 'insect' named entity 'NF-κB' named entity 'IgG' named entity 'Neuraminidase' named entity 'TB1' named entity 'DAPI' named entity 'filoviruses' named entity 'MDCK' named entity 'goat' named entity 'virus infection' named entity 'filoviruses' named entity 'anti-viral' named entity 'monoclonal antibody' named entity 'Murine' named entity 'influenza viruses' named entity 'bat' named entity 'infection' named entity 'expression levels' named entity 'cell types'

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