About: Rapid replacement of human respiratory syncytial virus A with the ON1 genotype having 72 nucleotide duplication in G gene

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About: Rapid replacement of human respiratory syncytial virus A with the ON1 genotype having 72 nucleotide duplication in G gene Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Rapid replacement of human respiratory syncytial virus A with the ON1 genotype having 72 nucleotide duplication in G gene
Creator	Jung, Hee-Dong Kim, Dae-Won Kim, Kisoon Kim, You-Jin Lee, Wan-Ji Yun, Mi-Ran Lee, Lee, Han Ho, Yeon
Source	Elsevier; Medline; PMC
abstract	Human respiratory syncytial virus (HRSV) is the main cause of severe respiratory illness in young children and elderly people. We investigated the genetic characteristics of the circulating HRSV subgroup A (HRSV-A) to determine the distribution of genotype ON1, which has a 72-nucleotide duplication in attachment G gene. We obtained 456 HRSV-A positive samples between October 2008 and February 2013, which were subjected to sequence analysis. The first ON1 genotype was discovered in August 2011 and 273 samples were identified as ON1 up to February 2013. The prevalence of the ON1 genotype increased rapidly from 17.4% in 2011–2012 to 94.6% in 2012–2013. The mean evolutionary rate of G protein was calculated as 3.275 × 10(−3) nucleotide substitution/site/year and several positively selected sites for amino acid substitutions were located in the predicted epitope region. This basic and important information may facilitate a better understanding of HRSV epidemiology and evolution.
has issue date	2014-05-10(xsd:dateTime)
bibo:doi	10.1016/j.meegid.2014.05.007
bibo:pmid	24820343
has license	no-cc
sha1sum (hex)	78427daf88cab42881af0c2eed358fc3f05059ef
schema:url	https://doi.org/10.1016/j.meegid.2014.05.007
resource representing a document's title	Rapid replacement of human respiratory syncytial virus A with the ON1 genotype having 72 nucleotide duplication in G gene
has PubMed Central identifier	PMC7106136
has PubMed identifier	24820343
schema:publication	Infect Genet Evol
resource representing a document's body	covid:78427daf88cab42881af0c2eed358fc3f05059ef#body_text
is schema:about of	named entity 'calculated' named entity 'genetic' named entity 'investigated' named entity 'DISTRIBUTION' named entity 'G PROTEIN' named entity 'DETERMINE' named entity 'UP TO' named entity 'HRSV' named entity 'AUGUST' named entity 'INCREASED' named entity 'EVOLUTION' named entity 'NUCLEOTIDE' named entity 'OCTOBER' named entity 'FEBRUARY' named entity 'SEQUENCE ANALYSIS' named entity 'GENETIC' named entity '2011' named entity 'RESPIRATORY ILLNESS' named entity 'PREVALENCE' named entity 'EVOLUTIONARY RATE' named entity 'A 72' named entity 'CIRCULATING' named entity 'PREDICTED' named entity 'EPIDEMIOLOGY' named entity 'RAPIDLY' named entity 'CAUSE' named entity 'NUCLEOTIDE DUPLICATION' named entity 'GENE' named entity 'REGION' named entity 'SELECTED' named entity 'BASIC' named entity 'ATTACHMENT' named entity 'OBTAINED' named entity 'BETTER' named entity 'MEAN' named entity '803' named entity 'SUBGROUP A' covid:arg/78427daf88cab42881af0c2eed358fc3f05059ef named entity 'IMPORTANT' named entity 'EPITOPE' named entity 'ELDERLY PEOPLE' named entity 'RAPID' named entity 'GENE' named entity 'NUCLEOTIDE DUPLICATION' named entity 'REPLACEMENT' named entity 'HUMAN RESPIRATORY SYNCYTIAL VIRUS A' named entity 'GENOTYPE' named entity 'SEVERE' named entity 'HUMAN RESPIRATORY SYNCYTIAL VIRUS' named entity 'GENOTYPE' named entity '275' named entity 'SAMPLES' named entity 'INFORMATION' named entity 'CALCULATED' named entity 'LOCATED IN' named entity 'AMINO ACID SUBSTITUTIONS' named entity 'POSITIVE' named entity 'MAIN' named entity 'IDENTIFIED' named entity 'HRSV-A' named entity 'SUBSTITUTION' named entity 'YOUNG CHILDREN' named entity 'INVESTIGATED' named entity 'UNDERSTANDING' named entity 'PROTEIN ' named entity 'CHARACTERISTICS' named entity 'SITES' named entity 'sequence analysis' named entity 'determine' named entity 'samples' named entity 'positively selected' named entity 'October' named entity 'epidemiology'

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