About: Two Sides of the Coin: Ezrin/Radixin/Moesin and Merlin Control Membrane Structure and Contact Inhibition

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About: Two Sides of the Coin: Ezrin/Radixin/Moesin and Merlin Control Membrane Structure and Contact Inhibition Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Two Sides of the Coin: Ezrin/Radixin/Moesin and Merlin Control Membrane Structure and Contact Inhibition
Creator	Bermeister, Adam Curmi, Paul Goodchild, Sophia Michie, Katharine Robertson, Neil
source	Medline; PMC
abstract	The merlin-ERM (ezrin, radixin, moesin) family of proteins plays a central role in linking the cellular membranes to the cortical actin cytoskeleton. Merlin regulates contact inhibition and is an integral part of cell–cell junctions, while ERM proteins, ezrin, radixin and moesin, assist in the formation and maintenance of specialized plasma membrane structures and membrane vesicle structures. These two protein families share a common evolutionary history, having arisen and separated via gene duplication near the origin of metazoa. During approximately 0.5 billion years of evolution, the merlin and ERM family proteins have maintained both sequence and structural conservation to an extraordinary level. Comparing crystal structures of merlin-ERM proteins and their complexes, a picture emerges of the merlin-ERM proteins acting as switchable interaction hubs, assembling protein complexes on cellular membranes and linking them to the actin cytoskeleton. Given the high level of structural conservation between the merlin and ERM family proteins we speculate that they may function together.
has issue date	2019-04-23(xsd:dateTime)
bibo:doi	10.3390/ijms20081996
bibo:pmid	31018575
has license	cc-by
sha1sum (hex)	7846c73c25fafce260659a9f9aefbef6b514bf15
schema:url	https://doi.org/10.3390/ijms20081996
resource representing a document's title	Two Sides of the Coin: Ezrin/Radixin/Moesin and Merlin Control Membrane Structure and Contact Inhibition
has PubMed Central identifier	PMC6515277
has PubMed identifier	31018575
schema:publication	Int J Mol Sci
resource representing a document's body	covid:7846c73c25fafce260659a9f9aefbef6b514bf15#body_text
is schema:about of	named entity 'acting' named entity 'gene duplication' named entity 'radixin' named entity 'speculate' named entity 'proteins' named entity 'Moesin' named entity 'Ezrin' named entity 'Membrane' named entity 'linking' named entity 'vesicle' named entity 'metazoa' named entity 'conservation' named entity 'merlin' named entity 'proteins' named entity 'ERM' named entity 'Merlin' named entity 'Contact' named entity 'evolutionary history' named entity 'gene duplication' named entity 'protein complexes' named entity 'ERM proteins' named entity 'family of proteins' named entity 'ERM' named entity 'moesin' named entity 'Membrane Structure' named entity 'Contact Inhibition' named entity 'FERM domain' named entity 'crystal structure' named entity 'ADP' named entity 'FERM' named entity 'cytoplasmic dynein' named entity 'Mutation' named entity 'mammals' named entity 'phosphorylated' named entity 'protein' named entity 'phosphorylation sites' named entity 'radixin' named entity 'spectrin' named entity 'FERM' named entity 'ERM proteins' named entity 'FERM' named entity 'vertebrate' named entity 'SANS' named entity 'binding site' named entity 'E3 ubiquitin ligase' named entity 'CTD' named entity 'merlin' named entity 'ADP' named entity 'phosphorylatable' named entity 'moesin' named entity 'plasma membrane' named entity 'isoform' named entity 'merlin' named entity 'FERM' named entity 'lipid' named entity 'electrostatic interactions' named entity 'phosphorylated' named entity 'merlin' named entity 'actin' named entity 'F-actin' named entity 'paralogs' named entity 'FERM' named entity 'amino acids' named entity 'merlin' named entity 'integral membrane proteins' named entity 'rhabdomyosarcoma' named entity 'isoforms' named entity 'salt bridge' named entity 'ERM' named entity 'isoforms' named entity 'paralogs' named entity 'phosphorylation site' named entity 'CTD' named entity 'ERM' named entity 'proteasome' named entity 'protein-protein interactions' named entity 'CRL4'

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