About: Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely associated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients

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About: Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely associated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely associated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients
Creator	Yang, Bo Liu, Ying Feng, Yong Li, Feng Ding, Jinya Huang, Qianchuan Xiong, Jie Zhao, Chen, Yurou Men, Dong Qu, Yueming Xiaohua, Chen
topic	covid:7852aafdfb9e59e6af78a47af796325434f8922a#this
Source	MedRxiv
abstract	Background: Although the SARS-CoV-2 viral load detection of respiratory specimen has been widely used for novel coronavirus disease (COVID-19) diagnosis, it is undeniable that serum SARS-CoV-2 nucleic acid (RNAaemia) could be detected in a fraction of the COVID-19 patients. However, it is not clear that if the incidence of RNAaemia could be correlated with the occurrence of cytokine storm or with the specific class of patients. Methods: This study enrolled 48 patients with COVID-19 admitted to the General Hospital of Central Theater Command, PLA, a designated hospital in Wuhan, China. The patients were divided into three groups according to the Diagnosis and Treatment of New Coronavirus Pneumonia (version 6) published by the National Health Commission of China. The clinical and laboratory data were collected. The serum viral load detection and serum IL-6 levels were determined. Except for routine statistical analysis, Generalized Linear Models (GLMs) analysis was used to establish a patient status prediction model based on real-time RT-PCR Ct value. Findings: The Result showed that cases with RNAaemia were exclusively confirmed in critically ill patients group and appeared to reflect the illness severity. Further more, the inflammatory cytokine IL-6 levels were significantly elevated in critically ill patients, which is almost 10-folds higher than those in other patients. More importantly, the extremely high IL-6 level was closely correlated with the incidence of RNAaemia (R=0.902) and the vital signs of COVID-19 patients (R= -0.682). Interpretation: Serum SARS-CoV-2 viral load (RNAaemia) is strongly associated with cytokine storm and can be used to predict the poor prognosis of COVID-19 patients. Moreover, our results strongly suggest that cytokine IL-6 should be considered as a therapeutic target in critically ill patients with excessive inflammatory response.
has issue date	2020-03-03(xsd:dateTime)
bibo:doi	10.1101/2020.02.29.20029520
has license	medrxiv
sha1sum (hex)	7852aafdfb9e59e6af78a47af796325434f8922a
schema:url	https://doi.org/10.1101/2020.02.29.20029520
resource representing a document's title	Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely associated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients
resource representing a document's body	covid:7852aafdfb9e59e6af78a47af796325434f8922a#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/7852aafdfb9e59e6af78a47af796325434f8922a
is schema:about of	named entity 'COVID-19' named entity 'ASSOCIATED WITH' named entity 'SARS-CoV-2' named entity 'DETECTED' named entity 'SARS-COV-2' named entity 'CORRELATED' named entity 'NUCLEIC ACID' named entity 'SERUM' named entity 'VIRAL LOAD' named entity 'CYTOKINE STORM' named entity 'SPECIFIC' named entity 'COVID-19' named entity 'SARS-COV-2' named entity 'CRITICALLY ILL' named entity 'SERUM' named entity 'PATIENTS' named entity 'VIRAL LOAD' named entity 'USED' named entity 'RESPIRATORY' named entity 'CLASS' named entity 'DETECTION' named entity 'CLEAR' named entity 'INCIDENCE' named entity 'OCCURRENCE' named entity 'SPECIMEN' named entity 'FRACTION OF' named entity 'PATIENTS' named entity 'ELEVATED' named entity 'DETECTABLE' named entity 'LEVEL' named entity 'INTERLEUKIN 6' named entity 'COULD BE' covid:arg/7852aafdfb9e59e6af78a47af796325434f8922a named entity 'detection' named entity 'serum' named entity 'COVID-19' named entity 'coronavirus disease' named entity 'viral load' named entity 'cytokine storm' named entity 'interleukin 6' named entity 'IL-6' named entity 'SARS-CoV-2' named entity 'IL-6' named entity 'COVID' named entity 'prognosis' named entity 'cough' named entity 'prognosis' named entity 'infection' named entity 'pneumonia' named entity 'IL-6' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'China' named entity 'peripheral blood' named entity 'critically ill patients' named entity 'RNA' named entity 'AST' named entity 'IL-6' named entity 'public health emergency of international concern' named entity 'IL-6' named entity 'viral RNA' named entity 'General Hospital' named entity 'peer-reviewed' named entity 'COVID-19' named entity 'cytokine storm' named entity 'viral load' named entity 'critically ill patients' named entity 'Serum samples' named entity 'peer-reviewed' named entity 'SARS-CoV' named entity 'MERS-CoV' named entity 'medRxiv'

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