About: Common variations in TERT-CLPTM1L locus are reproducibly associated with the risk of nasopharyngeal carcinoma in Chinese populations

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About: Common variations in TERT-CLPTM1L locus are reproducibly associated with the risk of nasopharyngeal carcinoma in Chinese populations Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Common variations in TERT-CLPTM1L locus are reproducibly associated with the risk of nasopharyngeal carcinoma in Chinese populations
Creator	Zhang, Yang Zhang, Ying Zhang, Xiaoai He, Fuchu Zhai, Yun Zhang, Hongxing Zhou, Gangqiao Li, Peiyao Wang, Zhifu Xia, Xia Yu, Lixia Zeng, Yixin
Source	Medline; PMC
abstract	Associations between single nucleotide polymorphisms (SNPs) at 5p15 (TERT-CLPTM1L) and multiple cancer types have been reported. We examined whether polymorphisms in the TERT-CLPTM1L locus were related to the risk of developing nasopharyngeal carcinoma (NPC) among Chinese populations. In the first stage, 26 tag SNPs were genotyped in a Guangxi population (855 patients and 1036 controls). In the second stage, the SNPs, which showed significant association, were further genotyped in a Guangdong population (997 patients and 972 controls). Functional analyses were conducted to verify the biological relevance of the associated polymorphism. In the 1st stage, four SNPs (rs2736098, rs2735845, rs402710, and rs401681) were significantly associated with the risk of developing NPC. After the 2nd stage validation, rs2735845 and rs401681 were independently associated with the risk of developing NPC in the additive model (rs2735845, OR = 1.19, 95% CI = 1.04–1.37, P = 0.011; rs401681, OR = 0.85, 95% CI = 0.74–0.99, P = 0.034). Furthermore, we observed higher CLPTM1L messenger RNA levels in fetal mesenchymal stem cells from the rs2735845 G allele carriers compared with that from non-carriers. In addition, using an immunohistochemistry assay, we observed higher TERT and CLPTM1L levels in NPC tissues compared with that in non-cancerous nasopharyngeal tissues. Our findings suggest that polymorphisms in the TERT-CLPTM1L locus may play a role in mediating the susceptibility to NPC in Chinese populations.
has issue date	2015-11-26(xsd:dateTime)
bibo:doi	10.18632/oncotarget.6397
bibo:pmid	26621837
has license	cc-by
sha1sum (hex)	786da349a33148e24e09edd6378da80ea2f40e07
schema:url	https://doi.org/10.18632/oncotarget.6397
resource representing a document's title	Common variations in TERT-CLPTM1L locus are reproducibly associated with the risk of nasopharyngeal carcinoma in Chinese populations
has PubMed Central identifier	PMC4808031
has PubMed identifier	26621837
schema:publication	Oncotarget
resource representing a document's body	covid:786da349a33148e24e09edd6378da80ea2f40e07#body_text
is schema:about of	named entity 'POPULATIONS' named entity 'LOCUS' named entity 'additive model' named entity '95% CI' named entity '997' named entity 'addition' named entity 'levels' named entity 'assay' named entity 'Chinese' named entity 'variations' named entity '1ST' named entity 'RELATED' named entity '0.99' named entity 'PATIENTS' named entity 'TYPES' named entity 'MULTIPLE CANCER' named entity 'PLAY' named entity 'REPORTED' named entity 'FUNCTIONAL' named entity 'NASOPHARYNGEAL CARCINOMA' named entity '5P15' named entity 'POPULATIONS' named entity 'MEDIATING' named entity 'MESENCHYMAL STEM CELLS' named entity 'SUSCEPTIBILITY' named entity 'IMMUNOHISTOCHEMISTRY ASSAY' named entity 'RISK OF' named entity 'SIGNIFICANT' named entity 'CHINESE' named entity 'MODEL' named entity 'ASSOCIATIONS' named entity 'GUANGXI' named entity 'NPC' named entity 'VERIFY' named entity 'MESSENGER RNA' named entity '0.85' named entity '2ND' named entity 'SUGGEST' named entity 'CARRIERS' named entity '1.04' named entity '28855' named entity 'FIRST STAGE' named entity 'ASSOCIATED' named entity 'ASSOCIATED WITH' named entity 'CLPTM1L' named entity 'FINDINGS' named entity 'OBSERVED' named entity 'LOCUS' named entity 'COMPARED' named entity 'CLPTM1L' named entity 'FETAL' named entity 'ALLELE' named entity 'SNPS' named entity 'USING' named entity 'VALIDATION' named entity 'SECOND STAGE' named entity 'VARIATIONS' named entity 'POPULATION' named entity 'TERT' named entity 'CHINESE' named entity 'RISK OF' named entity 'NASOPHARYNGEAL CARCINOMA' named entity 'NASOPHARYNGEAL' named entity 'BIOLOGICAL' named entity 'SINGLE NUCLEOTIDE POLYMORPHISMS' named entity 'TAG' named entity 'HAVE' named entity 'NON-' named entity 'LEVELS' named entity 'POLYMORPHISM'

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