About: Human Bocavirus infection and respiratory tract disease identified in a UK patient cohort

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Human Bocavirus infection and respiratory tract disease identified in a UK patient cohort
Creator	Mcclure, C Tarr, Alexander Clark, Gemma Howson-Wells, Hannah Irving, William Bagasi, Arwa Soo, Shiu
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: Since its first isolation in 2005, Human Bocavirus (HBoV) has been repeatedly associated with acute respiratory tract infections, although its role in pathogenicity remains unclear due to high co-infection rates. OBJECTIVES: To assess HBoV prevalence and associated disease in a cohort of respiratory patients in the East Midlands, UK between 2015 and 2019. STUDY DESIGN: We initially investigated the undiagnosed burden of HBoV in a retrospective paediatric cohort sampled between 2015 and 2017 using an in-house PCR assay. HBoV was subsequently incorporated into the standard respiratory diagnostic pathway and we audited a calendar year of HBoV positive results between 2018 and 2019. RESULTS: Our retrospective PCR screening of previously routine diagnostic-negative samples from juvenile patients identified a 9% (n = 30) prevalence of HBoV type 1. These apparentHBoV1 mono-infections were frequently associated with respiratory tract symptoms, often severe including ventilation, oxygen and steroid intervention with 31% (n = 9) of individuals requiring intensive care. When HBoV screening was subsequently adopted into the routine respiratory diagnostic pathway, year-round infections were observed in both children and adults peaking in February. 185 of 9098 (2.03%) individuals were found to be HBoV positive with children aged 12-24 months the principally infected group. However, HBoV infection was also observed in patients aged over 60, predominantly as a mono-infection. 23% of the 185 unique patients were HBoV monoinfectedand persistent low-level DNA positivity was observed in 15 individuals up to 6-months after initial presentation. CONCLUSION: HBoV1 is a prevalent respiratory infection in the UK capable of causing serious monoinfections.
has issue date	2020-05-21(xsd:dateTime)
bibo:doi	10.1016/j.jcv.2020.104453
bibo:pmid	32534437
has license	no-cc
sha1sum (hex)	787c54fa5d1d09f0bf455ce98aa98e55a6b2d6b5
schema:url	https://doi.org/10.1016/j.jcv.2020.104453
resource representing a document's title	Human Bocavirus infection and respiratory tract disease identified in a UK patient cohort
has PubMed Central identifier	PMC7240277
has PubMed identifier	32534437
schema:publication	J Clin Virol
resource representing a document's body	covid:787c54fa5d1d09f0bf455ce98aa98e55a6b2d6b5#body_text
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