About: Equine immunoglobulin F(ab')(2) fragments protect cats against feline calicivirus infection

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About: Equine immunoglobulin F(ab')(2) fragments protect cats against feline calicivirus infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Equine immunoglobulin F(ab')(2) fragments protect cats against feline calicivirus infection
Creator	Zhang, Ying Wang, Kai Zhao, Yongkun Zhang, Shengnan Cao, Lili Guo, Yanbing Cui, Zhanding Dong, Guoying Hu, Guixue Li, Dengliang Niu, Jiangting Yi, Shushuai Zhao, Han
Source	Elsevier; Medline; PMC
abstract	Feline calicivirus (FCV) causes upper respiratory tract infections in felines and threatens the health of wild and domestic felines. Clinically, specific drugs to treat FCV have not yet been developed. Here, IgG was extracted from inactivated FCV-immunized horse sera. Equine F(ab')(2) fragments were obtained from pepsin-digested IgG and then purified by protein-G column chromatography. In our study, equine immunoglobulin F(ab')(2) fragments showed efficient neutralizing activity in vitro against FCV and had therapeutic and prophylactic effects in FCV-infected cats. The anti-FCV-specific F(ab')(2) fragment can significantly alleviate the clinical symptoms of FCV-infected cats and reduce the viral loads of the trachea, lung and spleen. These results indicate that the F(ab')(2) fragment prepared from inactivated FCV-immunized horses may be used as a prophylactic and therapeutic agent for diseases caused by FCV.
has issue date	2019-07-25(xsd:dateTime)
bibo:doi	10.1016/j.intimp.2019.105714
bibo:pmid	31352323
has license	no-cc
sha1sum (hex)	78e58657862c48436ca2ad3553e5e719ec187ead
schema:url	https://doi.org/10.1016/j.intimp.2019.105714
resource representing a document's title	Equine immunoglobulin F(ab')(2) fragments protect cats against feline calicivirus infection
has PubMed Central identifier	PMC7106254
has PubMed identifier	31352323
schema:publication	Int Immunopharmacol
resource representing a document's body	covid:78e58657862c48436ca2ad3553e5e719ec187ead#body_text
is schema:about of	named entity 'extracted' named entity 'prophylactic' named entity 'therapeutic' named entity 'infection' named entity 'IMMUNOGLOBULIN' named entity 'SPLEEN' named entity 'FRAGMENTS' named entity 'IGG' named entity 'SERA' named entity 'TREAT' named entity 'EFFICIENT' named entity 'EFFECTS' named entity 'IN VITRO' named entity 'DIGESTED' named entity 'DRUGS' named entity 'CLINICAL SYMPTOMS' named entity 'FRAGMENT' named entity 'THERAPEUTIC AGENT' named entity 'FELINE CALICIVIRUS INFECTION' named entity 'EQUINE' named entity 'UPPER RESPIRATORY TRACT INFECTIONS' named entity 'IMMUNOGLOBULIN' named entity 'CATS' named entity 'USED' named entity 'PURIFIED' named entity 'HERE' named entity 'PROPHYLACTIC' named entity 'FELINE CALICIVIRUS' named entity 'IMMUNIZED' named entity 'HORSES' named entity 'EQUINE' named entity 'HEALTH' named entity 'EXTRACTED' named entity 'COLUMN CHROMATOGRAPHY' named entity 'FRAGMENTS' named entity 'TRACHEA' named entity 'CAUSES' named entity 'PEPSIN' named entity 'LUNG' named entity 'ACTIVITY' named entity 'HAVE' named entity 'FELINES' named entity 'STUDY' named entity 'MAY BE' named entity 'WILD' named entity 'OBTAINED' named entity 'DOMESTIC' named entity 'INACTIVATED' named entity 'OUR' named entity 'DISEASES' named entity 'RESULTS' named entity 'SPECIFIC' named entity 'PREPARED' named entity 'HORSE' named entity 'VIRAL' named entity 'THESE' named entity 'FCV' named entity 'CATS' named entity 'REDUCE' named entity 'THERAPEUTIC' named entity 'PROTEIN' covid:arg/78e58657862c48436ca2ad3553e5e719ec187ead named entity 'loads' named entity 'upper respiratory tract infections' named entity 'fragment' named entity 'drugs' named entity 'horse' named entity 'effects' named entity 'reduce'

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