About: Initial Steps in Mammalian Autophagosome Biogenesis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Initial Steps in Mammalian Autophagosome Biogenesis
Creator	Jiang, Liwen Wang, Yanzhuang Li, Feng-Jun, China Grasso, Daniel Renna, Felipe Vaccaro, Maria Zhu, Ming
Source	Medline; PMC
abstract	During the last decade, autophagy has been pointed out as a central process in cellular homeostasis with the consequent implication in most cellular settings and human diseases pathology. At present, there is significant data available about molecular mechanisms that regulate autophagy. Nevertheless, autophagy pathway itself and its importance in different cellular aspects are still not completely clear. In this article, we are focused in four main aspects: (a) Induction of Autophagy: Autophagy is an evolutionarily conserved mechanism induced by nutrient starvation or lack of growth factors. In higher eukaryotes, autophagy is a cell response to stress which starts as a consequence of organelle damage, such as oxidative species and other stress conditions. (b) Initiation of Autophagy; The two major actors in this signaling process are mTOR and AMPK. These multitasking protein complexes are capable to summarize the whole environmental, nutritional, and energetic status of the cell and promote the autophagy induction by means of the ULK1-Complex, that is the first member in the autophagy initiation. (c) ULK1-Complex: This is a highly regulated complex responsible for the initiation of autophagosome formation. We review the post-transductional modifications of this complex, considering the targets of ULK1. (d)The mechanisms involved in autophagosome formation. In this section we discuss the main events that lead to the initial structures in autophagy. The BECN1-Complex with PI3K activity and the proper recognition of PI3P are one of these. Also, the transmembrane proteins, such as VMP1 and ATG9, are critically involved. The membrane origin and the cellular localization of autophagosome biogenesis will be also considered. Hence, in this article we present an overview of the current knowledge of the molecular mechanisms involved in the initial steps of mammalian cell autophagosome biogenesis.
has issue date	2018-10-23(xsd:dateTime)
bibo:doi	10.3389/fcell.2018.00146
bibo:pmid	30406104
has license	cc-by
sha1sum (hex)	79662c9f0c15fef224326790833945e2a1f88ce5
schema:url	https://doi.org/10.3389/fcell.2018.00146
resource representing a document's title	Initial Steps in Mammalian Autophagosome Biogenesis
has PubMed Central identifier	PMC6206277
has PubMed identifier	30406104
schema:publication	Front Cell Dev Biol
resource representing a document's body	covid:79662c9f0c15fef224326790833945e2a1f88ce5#body_text
is schema:about of	named entity 'evolutionarily conserved' named entity 'nutritional' named entity 'stress' named entity 'membrane' named entity 'stress' named entity 'aspects' named entity 'initiation' named entity 'clear' named entity 'localization' named entity 'growth factors' named entity 'Autophagy' named entity 'PI3K' named entity 'LACK' named entity 'HUMAN DISEASES' named entity 'INDUCTION' named entity 'THE CELL' named entity 'STATUS' named entity 'CLEAR' named entity 'AUTOPHAGY PATHWAY' named entity 'STRUCTURES' named entity 'A CELL' named entity 'REGULATED' named entity 'BIOGENESIS' named entity 'STEPS' named entity 'cellular' named entity 'Autophagy' named entity 'molecular mechanisms' named entity 'Induction' named entity 'summarize' named entity 'formation' named entity 'origin' named entity 'response' named entity 'implication' named entity 'Nevertheless' named entity 'consequent' named entity 'biogenesis' named entity 'central' named entity 'PI3K' named entity 'promote' named entity 'Initial' named entity 'autophagosome' named entity 'biogenesis' named entity 'autophagy' named entity 'BECN1' named entity 'autophagy' named entity 'cellular homeostasis' named entity 'organelle' named entity 'ULK1' named entity 'ULK1' named entity 'PI3P' named entity 'biogenesis' named entity 'Autophagy' named entity 'ULK1' named entity 'autophagosome' named entity 'Autophagosome' named entity 'dimerization' named entity 'signaling pathways' named entity 'phosphorylation' named entity 'Protein' named entity 'heterodimer' named entity 'molecular machinery' named entity 'synaptotagmin' named entity 'Tuberous sclerosis' named entity 'RAS pathway' named entity 'lysosome' named entity 'NEDD4L' named entity 'ATG4B' named entity 'autophagy' named entity 'cytoplasm' named entity 'Sirtuin 1' named entity 'DAPK' named entity 'TSC1/2' named entity 'autophagosome' named entity 'phosphorylates'

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