About: Steroid-induced osteonecrosis of the femoral head reveals enhanced reactive oxygen species and hyperactive osteoclasts

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About: Steroid-induced osteonecrosis of the femoral head reveals enhanced reactive oxygen species and hyperactive osteoclasts Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Steroid-induced osteonecrosis of the femoral head reveals enhanced reactive oxygen species and hyperactive osteoclasts
Creator	Wang, Chao He, Wei Chen, Kai Kenny, Jacob Zhang, Qingwen He, Jianbo Liu, Yuhao Pavlos, Nathan Xu, Jiake Yuan, Jinbo
Source	Medline; PMC
abstract	Steroid-induced osteonecrosis of the femoral head (ONFH) is a progressive bone disorder which typically results in femoral head collapse and hip joint dysfunction. It is well-accepted that abnormal osteoclast activity contributes to loss of bone structural integrity and subchondral fracture in ONFH. However, the pathophysiologic mechanisms underlying the recruitment and hyperactivation of osteoclasts in ONFH remain incompletely understood. We assessed the changes of reactive oxygen species (ROS) level and subsequent osteoclast alterations in steroid-induced osteonecrotic femoral heads from both patients and rat ONFH models. When compared with healthy neighboring bone, the necrotic region of human femoral head was characterized by robust up-regulated expression of osteoclast-related proteins [cathepsin K and tartrate-resistant acid phosphatase(TRAP)] but pronounced down-regulation of antioxidant enzymes (catalase, γ-glutamylcysteine synthetase [γ-GCSc], and superoxide dismutase 1 [SOD1]). In addition, the ratio of TNFSF11 (encoding RANKL)/TNFRSF11B (encoding OPG) was increased within the necrotic bone. Consistently, in rat ONFH models induced by methylprednisolone (MPSL) and imiquimod (IMI), significant bone loss in the femoral head was observed, attributable to increased numbers of TRAP positive osteoclasts. Furthermore, the decreased expression of antioxidant enzymes observed by immunoblotting was accompanied by increased ex-vivo ROS fluorescence signals of dihydroethidium (DHE) in rat ONFH models. Therefore, this study lends support to the rationale that antioxidant agents may be a promising therapeutic avenue to prevent or mitigate the progression of steroid-induced ONFH by inhibiting ROS level and hyperactive osteoclasts.
has issue date	2020-04-06(xsd:dateTime)
bibo:doi	10.7150/ijbs.40917
bibo:pmid	32398957
has license	cc-by
sha1sum (hex)	7976cbcebee2d0bdfd1ce0c5e870f9c1d716eea9
schema:url	https://doi.org/10.7150/ijbs.40917
resource representing a document's title	Steroid-induced osteonecrosis of the femoral head reveals enhanced reactive oxygen species and hyperactive osteoclasts
has PubMed Central identifier	PMC7211180
has PubMed identifier	32398957
schema:publication	Int J Biol Sci
resource representing a document's body	covid:7976cbcebee2d0bdfd1ce0c5e870f9c1d716eea9#body_text
is schema:about of	named entity 'hyperactive' named entity 'bone' named entity 'human' named entity 'IMI' named entity 'patients' named entity 'osteonecrosis' named entity 'osteonecrosis' named entity 'OSTEONECROSIS OF THE FEMORAL HEAD' named entity 'STUDY' covid:arg/7976cbcebee2d0bdfd1ce0c5e870f9c1d716eea9 named entity 'bone' named entity 'osteoclasts' named entity 'synthetase' named entity 'Therefore' named entity 'TRAP' named entity 'proteins' named entity 'neighboring' named entity 'ROS' named entity 'femoral' named entity 'antioxidant' named entity 'SOD1' named entity 'antioxidant' named entity 'TNFRSF11B' named entity 'assessed' named entity 'structural integrity' named entity 'femoral head' named entity 'pathophysiologic mechanisms' named entity 'fluorescence' named entity 'osteoclast' named entity 'rat' named entity 'femoral head' named entity 'necrotic' named entity 'antioxidant' named entity 'catalase' named entity 'imiquimod' named entity 'femoral head' named entity 'acid phosphatase' named entity 'immunoblotting' named entity 'Steroid' named entity 'up-regulated' named entity 'RANKL' named entity 'osteonecrosis' named entity 'Oxidative stress' named entity 'metabolic diseases' named entity 'femoral head' named entity 'Joint space' named entity 'oxidative stress' named entity 'image reconstruction' named entity 'homeostasis' named entity 'protein' named entity 'osteoclast' named entity 'RANKL' named entity 'steroid' named entity 'femoral head' named entity 'Oxidative stress' named entity 'haemodialysis' named entity 'coagulation abnormalities' named entity 'necrotic' named entity 'gene expression' named entity 'mortar and pestle' named entity 'antioxidant' named entity 'osteoclast' named entity 'osteonecrosis' named entity 'femoral head' named entity 'osteoclasts' named entity 'gene' named entity 'osteoclasts' named entity 'pathogenesis' named entity 'SOD1' named entity 'Leica' named entity 'catalase' named entity 'subchondral bone'

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