About: Programmed ribosomal frameshifting in decoding the SARS-CoV genome

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Programmed ribosomal frameshifting in decoding the SARS-CoV genome
Creator	Anderson, Christine Atkins, John Baranov, Pavel Gesteland, Raymond Henderson, Clark Howard, Michael
Source	Elsevier; Medline; PMC
abstract	Abstract Programmed ribosomal frameshifting is an essential mechanism used for the expression of orf1b in coronaviruses. Comparative analysis of the frameshift region reveals a universal shift site U_UUA_AAC, followed by a predicted downstream RNA structure in the form of either a pseudoknot or kissing stem loops. Frameshifting in SARS-CoV has been characterized in cultured mammalian cells using a dual luciferase reporter system and mass spectrometry. Mutagenic analysis of the SARS-CoV shift site and mass spectrometry of an affinity tagged frameshift product confirmed tandem tRNA slippage on the sequence U_UUA_AAC. Analysis of the downstream pseudoknot stimulator of frameshifting in SARS-CoV shows that a proposed RNA secondary structure in loop II and two unpaired nucleotides at the stem I–stem II junction in SARS-CoV are important for frameshift stimulation. These results demonstrate key sequences required for efficient frameshifting, and the utility of mass spectrometry to study ribosomal frameshifting.
has issue date	2005-02-20(xsd:dateTime)
bibo:doi	10.1016/j.virol.2004.11.038
bibo:pmid	15680415
has license	els-covid
sha1sum (hex)	798f848bfe9a46c23560c06984aab9637c08c907
schema:url	https://doi.org/10.1016/j.virol.2004.11.038
resource representing a document's title	Programmed ribosomal frameshifting in decoding the SARS-CoV genome
has PubMed Central identifier	PMC7111862
has PubMed identifier	15680415
schema:publication	Virology
resource representing a document's body	covid:798f848bfe9a46c23560c06984aab9637c08c907#body_text
is schema:about of	named entity 'SARS-CoV' named entity 'mass spectrometry' named entity 'decoding' named entity 'THESE' named entity 'PROPOSED' named entity 'LOOPS' named entity 'SITE' named entity 'EXPRESSION' named entity 'KISSING' named entity 'STEM' named entity 'SHIFT' named entity 'AAC' named entity 'EITHER' named entity 'FOLLOWED BY' named entity 'PSEUDOKNOT' named entity 'USED' named entity 'KEY' named entity 'IMPORTANT' named entity 'UUA' named entity 'CHARACTERIZED' named entity 'COMPARATIVE ANALYSIS' named entity 'REQUIRED' named entity 'SARS-COV' named entity 'DECODING' named entity 'RESULTS' named entity 'RIBOSOMAL' named entity 'CELLS' named entity 'CORONAVIRUSES' named entity 'STIMULATOR' named entity 'GENOME' named entity 'RNA STRUCTURE' named entity 'SEQUENCE' named entity 'PREDICTED' named entity 'MUTAGENIC' named entity 'FRAMESHIFT' named entity 'REPORTER' named entity 'TRNA' named entity 'LOOP' named entity 'USING' named entity 'STUDY' named entity 'AFFINITY' named entity 'ANALYSIS' named entity 'MAMMALIAN' named entity 'RIBOSOMAL' named entity 'FORM' named entity 'MECHANISM' named entity 'SEQUENCES' named entity 'SARS-COV' named entity 'UNIVERSAL' named entity 'REGION' named entity 'UTILITY' named entity 'PRODUCT' named entity 'STIMULATION' named entity 'DUAL' named entity 'ESSENTIAL' named entity 'CONFIRMED' named entity 'NUCLEOTIDES' named entity 'JUNCTION' named entity 'SYSTEM' named entity 'DOWNSTREAM' named entity 'UNPAIRED' named entity 'TAGGED' named entity 'RNA SECONDARY STRUCTURE' named entity 'CULTURED' named entity 'LUCIFERASE' named entity 'TANDEM' named entity 'EFFICIENT' named entity 'MASS SPECTROMETRY' named entity 'REVEALS' named entity 'sequence' named entity 'secondary structure' named entity 'structure' named entity 'ribosomal frameshifting' named entity 'AAC' named entity 'RNA' named entity 'tRNA'

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