About: Immunogenicity of a receptor-binding domain of SARS coronavirus spike protein in mice: Implications for a subunit vaccine

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Immunogenicity of a receptor-binding domain of SARS coronavirus spike protein in mice: Implications for a subunit vaccine Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Immunogenicity of a receptor-binding domain of SARS coronavirus spike protein in mice: Implications for a subunit vaccine
Creator	Zakhartchouk, Alexander Petric, Martin Cameron, Cheryl Kelvin, David Satkunarajah, Malathy Sharon, Chetna Auperin, Thierry Cochrane, Alan Mutwiri, George Viswanathan, Sathiyanarayanan Babiuk, Lorne Brunham, Robert Finlay, B Rini, James See, Raymond
Source	Elsevier; Medline; PMC
abstract	Abstract We studied the immunogenicity of an anti-SARS subunit vaccine comprised of the fragment of the SARS coronavirus (SARS-CoV) spike protein amino acids 318–510 (S318–510) containing the receptor-binding domain. The S protein fragment was purified from the culture supernatant of stably transformed HEK293T cells secreting a tagged version of the protein. The vaccine was given subcutaneously to 129S6/SvEv mice in saline, with alum adjuvant or with alum plus CpG oligodeoxynucleotides (ODN). Mice immunized with the adjuvanted antigen elicited strong antibody and cellular immune responses; furthermore, adding the CpG ODN to the alum resulted in increased IgG2a antibody titers and a higher number of INF-γ-secreting murine splenocytes. Mice vaccinated with S318–510 deglycosylated by PNGase F (dgS318–510) showed a lower neutralizing antibody response but had similar numbers of INF-γ-producing cells in the spleen. This finding suggests that carbohydrate is important for the immunogenicity of the S318–510 protein fragment and provide useful information for designing an effective and safe SARS subunit vaccine.
has issue date	2007-01-02(xsd:dateTime)
bibo:doi	10.1016/j.vaccine.2006.06.084
bibo:pmid	16919855
has license	els-covid
sha1sum (hex)	79a82ee9007a1ecba6be491e8c675f3d00becba4
schema:url	https://doi.org/10.1016/j.vaccine.2006.06.084
resource representing a document's title	Immunogenicity of a receptor-binding domain of SARS coronavirus spike protein in mice: Implications for a subunit vaccine
has PubMed Central identifier	PMC7115608
has PubMed identifier	16919855
schema:publication	Vaccine
resource representing a document's body	covid:79a82ee9007a1ecba6be491e8c675f3d00becba4#body_text
is schema:about of	named entity 'SARS CORONAVIRUS' named entity 'MICE' named entity 'PROTEIN ' named entity 'NUMBER OF' named entity 'TRANSFORMED' named entity 'STRONG' named entity 'INF' named entity 'MICE' named entity 'BINDING' named entity 'SIMILAR' named entity 'LOWER' named entity 'VERSION' named entity 'SARS' named entity 'BUT' named entity 'ANTIBODY RESPONSE' named entity 'SPIKE PROTEIN' named entity 'IMMUNE RESPONSES' named entity 'ALUM' named entity 'CELLS' named entity 'ANTIBODY TITERS' named entity 'SUBUNIT VACCINE' named entity 'PROTEIN ' named entity 'BINDING' named entity 'RECEPTOR' named entity 'OLIGODEOXYNUCLEOTIDES' named entity 'CARBOHYDRATE' named entity 'GIVEN' named entity 'PROTEIN FRAGMENT' named entity 'ANTIBODY' named entity 'ALUM ADJUVANT' named entity 'SAFE' named entity 'S PROTEIN' named entity 'SUBUNIT VACCINE' named entity 'TAGGED' named entity 'SALINE' named entity 'IMMUNOGENICITY' named entity 'ADJUVANTED' named entity 'FRAGMENT OF' named entity 'IMMUNOGENICITY' named entity '90%' named entity 'NEUTRALIZING ANTIBODY' named entity 'CELLULAR' named entity 'USEFUL INFORMATION' named entity 'CONTAINING' named entity 'VACCINE' named entity 'RECEPTOR' named entity 'AMINO ACIDS' named entity 'ANTIGEN' named entity 'INCREASED' named entity 'ADDING' named entity 'DOMAIN' named entity 'CULTURE SUPERNATANT' named entity 'HIGHER' named entity 'PNGASE F' named entity 'IMMUNIZED' named entity 'DOMAIN' named entity 'PURIFIED' named entity 'PROVIDE' named entity 'EFFECTIVE' named entity 'PROTEIN' named entity 'SPLEEN' named entity 'FINDING' named entity 'MURINE SPLENOCYTES' named entity 'CPG' named entity 'IMPORTANT' named entity 'SARS CORONAVIRUS' named entity 'SECRETING'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software