About: The Adamantane-Derived Bananins Are Potent Inhibitors of the Helicase Activities and Replication of SARS Coronavirus

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About: The Adamantane-Derived Bananins Are Potent Inhibitors of the Helicase Activities and Replication of SARS Coronavirus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Adamantane-Derived Bananins Are Potent Inhibitors of the Helicase Activities and Replication of SARS Coronavirus
Creator	Guan, Y Poon, L Lim, W Agt, Cheung, M Davies, W Gcc Aat Gcc, Ggt Gta Aa-3# ; Nicholls, J Grunert, R Haff, R Lai, S Mcgahen, J Neu- Peiris, J Yam, L Yan, W Yee, W
Source	Elsevier; Medline; PMC
abstract	Bananins are a class of antiviral compounds with a unique structural signature incorporating a trioxa-adamantane moiety covalently bound to a pyridoxal derivative. Six members of this class of compounds: bananin, iodobananin, vanillinbananin, ansabananin, eubananin, and adeninobananin were synthesized and tested as inhibitors of the SARS Coronavirus (SCV) helicase. Bananin, iodobananin, vanillinbananin, and eubananin were effective inhibitors of the ATPase activity of the SCV helicase with IC(50) values in the range 0.5–3 μM. A similar trend, though at slightly higher inhibitor concentrations, was observed for inhibition of the helicase activities, using a FRET-based fluorescent assay. In a cell culture system of SCV, bananin exhibited an EC(50) of less than 10 μM and a CC(50) of over 300 μM. Kinetics of inhibition are consistent with bananin inhibiting an intracellular process or processes involved in SCV replication.
has issue date	2005-03-25(xsd:dateTime)
bibo:doi	10.1016/j.chembiol.2005.01.006
bibo:pmid	15797214
has license	no-cc
sha1sum (hex)	79ba46fafc5a6279ea9cc27ff3a5d5dddaacdf96
schema:url	https://doi.org/10.1016/j.chembiol.2005.01.006
resource representing a document's title	The Adamantane-Derived Bananins Are Potent Inhibitors of the Helicase Activities and Replication of SARS Coronavirus
has PubMed Central identifier	PMC7110988
has PubMed identifier	15797214
schema:publication	Chem Biol
resource representing a document's body	covid:79ba46fafc5a6279ea9cc27ff3a5d5dddaacdf96#body_text
is schema:about of	named entity 'ACTIVITIES' named entity 'Pokfulam' named entity 'RNA' named entity 'leading' named entity 'Germany' named entity 'case' named entity 'viral' named entity 'slight' named entity 'SARS Coronavirus' named entity 'cell culture' named entity 'inhibitors' named entity 'clear' named entity 'consistent' named entity 'arterivirus' named entity 'virus' named entity 'Center' named entity 'China' named entity 'sis' named entity 'assay' named entity 'effective' named entity 'process' named entity 'helicase' named entity 'SARS Coronavirus' named entity 'drugs' named entity 'PARKINSON' named entity 'DRUG' named entity 'RIMANTADINE' named entity 'TROMANTADINE' named entity 'CYTOTOXIC' named entity 'DERIVATIVE' named entity 'POLARITY' named entity 'MAJOR' named entity 'PLANT' named entity 'OPEN' named entity 'TREATMENTS' named entity 'HELICASES' named entity 'DETERMINATION' named entity 'ANTAGONISTA' named entity 'METAL' named entity 'HERPES SIMPLEX VIRUS' named entity 'TORA' named entity 'VIABILITY' named entity 'CONJUGATED' named entity 'INTRACELLULAR' named entity 'VALUES' named entity 'DRUGS' named entity 'INHIBITION' named entity 'CELL CULTURE SYSTEM' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'USING' named entity 'ADA' named entity 'IDENTIFICATION' named entity 'SUMMARY' named entity 'RINGS' named entity 'UNUSUAL' named entity 'CHEMISTRY' named entity 'BIOCHEMISTRY' named entity 'ANIMAL' named entity 'MODELS' named entity 'BOUND' named entity 'DESCRIBED' named entity 'EMERGING INFECTIOUS DISEASES' named entity 'SUBMITTED' named entity 'CONSISTENT WITH' named entity 'UNIVERSITY OF HONG KONG' named entity 'POSSESSES'

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