About: Magnesium and vitamin C supplementation attenuates steroid-associated osteonecrosis in a rat model

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About: Magnesium and vitamin C supplementation attenuates steroid-associated osteonecrosis in a rat model Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Magnesium and vitamin C supplementation attenuates steroid-associated osteonecrosis in a rat model
Creator	Qin, Ling Wang, Xin-Luan Huang, Le Zheng, Li-Zhen Pang, Qian-Qian Wang, Jia-Li Zhao, De-Wei He, Xuan Liu, Bao-Yi Mi, Jie Ruan, Ye-Chun Xu, Jian-Kun Zhang, Ri Zhang, Xiao-Tian Zu, Hai-Yue
topic	covid:79db3ad22434b309c81d5495d0f9399722593181#this
Source	Elsevier; Medline; PMC
abstract	Abstract Magnesium (Mg)-based biometal attracts clinical applications due to its biodegradability and beneficial biological effects on tissue regeneration, especially in orthopaedics, yet the underlying anabolic mechanisms in relevant clinical disorders are lacking. The present study investigated the effect of magnesium (Mg) and vitamin C (VC) supplementation for preventing steroid-associated osteonecrosis (SAON) in a rat experimental model. In SAON rats, 50 mg/kg Mg, or 100 mg/kg VC, or combination, or water control was orally supplemented daily for 2 or 6 weeks respectively. Osteonecrosis was evaluated by histology. Serum Mg, VC, and bone turnover markers were measured. Microfil-perfused samples prepared for angiography and trabecular architecture were evaluated by micro-CT. Primary bone marrow cells were isolated from each group to evaluate their potentials in osteoblastogenesis and osteoclastogenesis. The mechanisms were tested in vitro. Histological evaluation showed SAON lesions in steroid treated groups. Mg and VC supplementation synergistically reduced the apoptosis of osteocytes and osteoclast number, and increased osteoblast surface. VC supplementation significantly increased the bone formation marker PINP, and the combination significantly decreased the bone resorption marker CTX. TNFα expression and oxidative injury were decreased in bone marrow in Mg/VC/combination group. Mg significantly increased the blood perfusion in proximal tibia and decreased the leakage particles in distal tibia 2 weeks after SAON induction. VC significantly elevated the osteoblast differentiation potential of marrow cells and improved the trabecular architecture. The combination supplementation significantly inhibited osteoclast differentiation potential of marrow cells. In vitro study showed promoting osteoblast differentiation effect of VC, and anti-inflammation and promoting angiogenesis effect of Mg with underlying mechanisms. Mg and VC supplementation could synergistically alleviate SAON in rats, indicating great translational potentials of metallic minerals for preventing SAON.
has issue date	2020-04-30(xsd:dateTime)
bibo:doi	10.1016/j.biomaterials.2020.119828
bibo:pmid	32045781
has license	els-covid
sha1sum (hex)	79db3ad22434b309c81d5495d0f9399722593181
schema:url	https://doi.org/10.1016/j.biomaterials.2020.119828
resource representing a document's title	Magnesium and vitamin C supplementation attenuates steroid-associated osteonecrosis in a rat model
has PubMed Central identifier	PMC7185815
has PubMed identifier	32045781
schema:publication	Biomaterials
resource representing a document's body	covid:79db3ad22434b309c81d5495d0f9399722593181#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/79db3ad22434b309c81d5495d0f9399722593181
is schema:about of	named entity 'tibia' named entity 'water control' named entity 'mechanisms' named entity 'mechanisms' named entity 'Primary' named entity 'rats' named entity 'MAGNESIUM' named entity 'ASSOCIATED' named entity 'OSTEONECROSIS' named entity 'STEROID' named entity 'PROXIMAL TIBIA' named entity 'OSTEOCLAST DIFFERENTIATION' named entity 'RAT MODEL' named entity 'MEASURED' named entity 'BONE FORMATION MARKER' named entity 'MG%' named entity 'INDICATING' named entity 'IN VITRO STUDY' named entity 'UNDERLYING' named entity 'LEAKAGE' named entity 'PINP' named entity 'BONE TURNOVER' named entity 'INHIBITED' named entity 'PROMOTING' named entity 'TREATED' named entity 'TISSUE REGENERATION' covid:arg/79db3ad22434b309c81d5495d0f9399722593181 named entity 'ANGIOGENESIS EFFECT' named entity 'MECHANISMS' named entity 'MARROW' named entity 'BASED' named entity 'EXPRESSION' named entity 'EFFECTS' named entity 'BONE MARROW' named entity 'ISOLATED' named entity 'MARKERS' named entity 'PARTICLES' named entity 'EVALUATED' named entity 'RAT' named entity 'HISTOLOGY' named entity '100' named entity 'APOPTOSIS' named entity 'BIODEGRADABILITY' named entity 'POTENTIALS' named entity 'CONTROL' named entity 'OSTEOBLAST DIFFERENTIATION' named entity 'BIOLOGICAL' named entity 'BONE RESORPTION MARKER' named entity 'OSTEOCYTES' named entity 'STUDY' named entity 'MICRO-CT' named entity 'TIBIA 2' named entity 'WATER' named entity 'INVESTIGATED' named entity 'VITAMIN C SUPPLEMENTATION' named entity 'STEROID' named entity 'POTENTIAL' named entity 'MINERALS' named entity 'DECREASED' named entity 'PREVENTING' named entity 'HISTOLOGICAL' named entity 'INDUCTION' named entity 'SUPPLEMENTATION' named entity 'CTX' named entity 'BENEFICIAL'

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