About: Distal airway stem cells ameliorate bleomycin-induced pulmonary fibrosis in mice

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Distal airway stem cells ameliorate bleomycin-induced pulmonary fibrosis in mice
Creator	Chen, Min Shi, Yun Zhou, Yueqing Zuo, Wei Dong, Mingqing Gao, Yongheng Han, Luyao Jin, Faguang Li, Wangping Lin, Hongwei
source	PMC
abstract	BACKGROUND: Idiopathic pulmonary fibrosis is characterized by loss of lung epithelial cells and inexorable progression of fibrosis with no effective and approved treatments. The distal airway stem/progenitor cells (DASCs) have been shown to have potent regenerative capacity after lung injury. In this work, we aimed to define the role of mouse DASCs (mDASCs) in response to bleomycin-induced lung fibrosis in mice. METHODS: The mDASCs were isolated, expanded in vitro, and labeled with GFP by lentiviral infection. The labeled mDASCs were intratracheally instilled into bleomycin-induced pulmonary fibrosis mice on day 7. Pathological change, collagen content, α-SMA expression, lung function, and mortality rate were assessed at 7, 14, and 21 days after bleomycin administration. Tissue section and direct fluorescence staining was used to show the distribution and differentiation of mDASCs in lung. RESULTS: The transplanted mDASCs could incorporate, proliferate, and differentiate into type I pneumocytes in bleomycin-injured lung. They also inhibited fibrogenesis by attenuating the deposition of collagen and expression of α-SMA. In addition, mDASCs improved pulmonary function and reduce mortality in bleomycin-induced pulmonary fibrosis mice. CONCLUSIONS: The data strongly suggest that mDASCs could ameliorate bleomycin-induced pulmonary fibrosis by promotion of lung regeneration and inhibition of lung fibrogenesis. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13287-019-1257-2) contains supplementary material, which is available to authorized users.
has issue date	2019-06-03(xsd:dateTime)
bibo:doi	10.1186/s13287-019-1257-2
bibo:pmid	31159891
has license	cc-by
sha1sum (hex)	79f3c77ca03c6c98eea660b3b629c3c3feff03ec
schema:url	https://doi.org/10.1186/s13287-019-1257-2
resource representing a document's title	Distal airway stem cells ameliorate bleomycin-induced pulmonary fibrosis in mice
has PubMed Central identifier	PMC6547529
has PubMed identifier	31159891
schema:publication	Stem Cell Res Ther
resource representing a document's body	covid:79f3c77ca03c6c98eea660b3b629c3c3feff03ec#body_text
is schema:about of	named entity 'distal' named entity 'fibrosis' named entity 'IDIOPATHIC PULMONARY FIBROSIS' named entity 'CAPACITY' named entity 'CHARACTERIZED' named entity 'lung injury' named entity 'progression' named entity 'Idiopathic pulmonary fibrosis' named entity 'Distal' named entity 'pulmonary fibrosis' named entity 'mice' named entity 'fibrosis' named entity 'Idiopathic pulmonary fibrosis' named entity 'pulmonary fibrosis' named entity 'fibrosis' named entity 'Ki67' named entity 'aorta' named entity 'H&E' named entity 'collagen' named entity 'hydroxyproline' named entity 'citrate' named entity 'trypsin' named entity 'hydroxyproline' named entity 'basal cells' named entity 'blood samples' named entity 'basal cells' named entity 'lungs' named entity 'pulmonary function' named entity 'bleomycin' named entity 'immunofluorescence' named entity 'extracellular matrix' named entity 'bleomycin' named entity '1:500' named entity 'staining' named entity 'C.T' named entity 'multiple comparisons' named entity 'pulmonary fibrosis' named entity 'Roche' named entity 'Fibrosis' named entity 'pulmonary injury' named entity 'log rank test' named entity 'lung function' named entity 'microtome' named entity 'bleomycin' named entity 'hydroxyproline' named entity 'bleomycin' named entity 'pulmonary fibrosis' named entity 'homogenized' named entity 'pulmonary function' named entity 'collagen' named entity 'immunomodulatory' named entity 'DAPI' named entity 'saline' named entity 'total protein' named entity 'Lentivirus' named entity 'GFP' named entity 'formaldehyde' named entity 'pulmonary function' named entity 'diaphragm' named entity 'organoids' named entity 'bleomycin' named entity 'bleomycin' named entity 'cervix' named entity 'HGF' named entity 'basal cells' named entity 'fluorescence' named entity 'alveolar septa' named entity 'inflammatory cell' named entity 'bleomycin' named entity 'fluorescence' named entity 'control group' named entity 'cervix'

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