About: Serum neopterin for early assessment of severity of severe acute respiratory syndrome

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Serum neopterin for early assessment of severity of severe acute respiratory syndrome
Creator	Bergmann, Andreas Cao, Kai-Yuan Di, Biao Duan, Zhao-Hui Fuchs, Dietmar Gao, Yang Lehmann, Matthias Leung, Manfai Leung, Wingman Renneberg, Ilka Renneberg, Reinhard Wang, Ming Zheng, Bojian Chan, Paul Rg, Jö Tam, John Cautherley, George Chan, Cangel Choi, Junet Hollidt, M
source	Elsevier; Medline; PMC
abstract	Neopterin and C-reactive protein (CRP) concentrations were determined in serum samples from 129 severe acute respiratory syndrome (SARS) patients and 156 healthy blood donors. In the patients with confirmed SARS, an early neopterin elevation was detected already at the day of onset of symptoms and rose to a maximum level of 45.0 nmol/L 3 days after the onset. All SARS patients had elevated neopterin concentrations (>10 nmol/L) within 9 days after the onset. The mean neopterin concentrations were 34.2 nmol/L in acute sera of SARS patients, 5.1 nmol/L in convalescent sera, and 6.7 nmol/L in healthy controls. In contrast, the mean CRP concentrations in both acute and convalescent sera of SARS patients were in the normal range (<10 mg/L). Serum neopterin level in SARS patients was associated with fever period and thus the clinical progression of the disease, while there was no significant correlation between the CRP level and the fever period. Serum neopterin may allow early assessment of the severity of SARS. The decrease of neopterin level was found after steroid treatment, which indicates that blood samples should be collected before steroid treatment for the neopterin measurement.
has issue date	2005-04-25(xsd:dateTime)
bibo:doi	10.1016/j.clim.2005.03.009
bibo:pmid	15925828
has license	no-cc
sha1sum (hex)	7acb4567a32041904593b27ebdb13d4349bcf59c
schema:url	https://doi.org/10.1016/j.clim.2005.03.009
resource representing a document's title	Serum neopterin for early assessment of severity of severe acute respiratory syndrome
has PubMed Central identifier	PMC7106326
has PubMed identifier	15925828
schema:publication	Clin Immunol
resource representing a document's body	covid:7acb4567a32041904593b27ebdb13d4349bcf59c#body_text
is schema:about of	named entity 'PERIOD' named entity 'CONCENTRATIONS' named entity 'FOUND' named entity 'MG%' named entity 'DISEASE' named entity 'DETECTED' named entity 'BLOOD DONORS' named entity 'PROTEIN ' named entity 'ALLOW' named entity '3C10' named entity 'CONVALESCENT' named entity 'SIGNIFICANT' named entity 'CORRELATION' named entity 'DETERMINED' named entity 'CONFIRMED' named entity 'LEVEL' named entity 'ELEVATION' named entity 'CRP' named entity 'serum' named entity 'CRP' named entity 'correlation' named entity 'patients' named entity 'BLOOD SAMPLES' named entity 'HEALTHY' named entity 'CONTRAST' named entity 'ACUTE' named entity 'NEOPTERIN MEASUREMENT' covid:arg/7acb4567a32041904593b27ebdb13d4349bcf59c named entity 'NEOPTERIN' named entity 'ASSOCIATED WITH' named entity 'ASSESSMENT' named entity 'DECREASE' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'COLLECTED' named entity 'NEOPTERIN' named entity 'SAMPLES' named entity 'ASSESSMENT' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'STEROID TREATMENT' named entity 'ONSET OF SYMPTOMS' named entity '129' named entity 'ONSET' named entity 'FEVER' named entity '156' named entity '34.2' named entity 'CRP' named entity 'EARLY' named entity 'ROSE' named entity 'CLINICAL PROGRESSION' named entity 'EARLY' named entity 'SEVERITY' named entity 'SERUM' named entity 'SEVERITY' named entity 'MAXIMUM' named entity 'PATIENTS' named entity 'NORMAL RANGE' named entity 'ELEVATED' named entity 'DAYS' named entity 'MEAN' named entity 'SERA' named entity 'C-REACTIVE PROTEIN' named entity 'SERUM'

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